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Physics-informed neural networks (PINNs) have emerged as a promising approach to solving partial differential equations (PDEs) using neural networks, particularly in data-scarce scenarios, due to their unsupervised training capability.…

Machine Learning · Computer Science 2025-03-25 Edgar Torres , Jonathan Schiefer , Mathias Niepert

Scientific machine learning (SciML) represents a significant advancement in integrating machine learning (ML) with scientific methodologies. At the forefront of this development are Physics-Informed Neural Networks (PINNs), which offer a…

Machine Learning · Computer Science 2024-11-19 Reyhaneh Taj

Inverse problems arise almost everywhere in science and engineering where we need to infer on a quantity from indirect observation. The cases of medical, biomedical, and industrial imaging systems are the typical examples. A very high…

Machine Learning · Computer Science 2025-02-20 Ali Mohammad-Djafari

Data-driven discovery of governing equations in computational science has emerged as a new paradigm for obtaining accurate physical models and as a possible alternative to theoretical derivations. The recently developed physics-informed…

Machine Learning · Computer Science 2023-10-18 Zongren Zou , Xuhui Meng , George Em Karniadakis

Physics-informed neural networks (PINNs) and their variants have been very popular in recent years as algorithms for the numerical simulation of both forward and inverse problems for partial differential equations. This article aims to…

Numerical Analysis · Mathematics 2024-11-20 Tim De Ryck , Siddhartha Mishra

Physics-informed neural networks (PINNs) are an influential method of solving differential equations and estimating their parameters given data. However, since they make use of neural networks, they provide only a point estimate of…

Machine Learning · Computer Science 2024-05-15 Lena Podina , Mahdi Torabi Rad , Mohammad Kohandel

Physics-informed neural networks (PINNs) are numerical solvers that embed all the physical information of a system into the loss function of a neural network. In this way the learned solution accounts for data (if available), the governing…

Computational Physics · Physics 2025-07-30 Andrés Martínez-Esteban , Pablo Calvo-Barlés , Luis Martín-Moreno , Sergio G Rodrigo

Physics-Informed Neural Networks (PINNs) are machine learning tools that approximate the solution of general partial differential equations (PDEs) by adding them in some form as terms of the loss/cost function of a Neural Network. Most…

Numerical Analysis · Mathematics 2022-08-29 Antonio Tadeu Azevedo Gomes , Larissa Miguez da Silva , Frederic Valentin

In this paper, we present a novel methodology for automatic adaptive weighting of Bayesian Physics-Informed Neural Networks (BPINNs), and we demonstrate that this makes it possible to robustly address multi-objective and multi-scale…

Computational Physics · Physics 2023-08-09 Sarah Perez , Suryanarayana Maddu , Ivo F. Sbalzarini , Philippe Poncet

Physics-Informed Neural Networks (PINNs) have emerged as a powerful tool for integrating physics-based constraints and data to address forward and inverse problems in machine learning. Despite their potential, the implementation of PINNs…

Optimization and Control · Mathematics 2024-12-19 Alan Williams , Christopher Leon , Alexander Scheinker

Physics-informed neural networks (PINNs) have recently emerged as an alternative way of solving partial differential equations (PDEs) without the need of building elaborate grids, instead, using a straightforward implementation. In…

Analysis of PDEs · Mathematics 2019-09-04 Dongkun Zhang , Lu Lu , Ling Guo , George Em Karniadakis

Physics-informed neural networks (PINNs) have emerged as a powerful tool for solving inverse problems, especially in cases where no complete information about the system is known and scatter measurements are available. This is especially…

Computational Engineering, Finance, and Science · Computer Science 2023-08-03 Jeremias Garay , Jocelyn Dunstan , Sergio Uribe , Francisco Sahli Costabal

In recent years, Physics-Informed Neural Networks (PINNs) have become a representative method for solving partial differential equations (PDEs) with neural networks. PINNs provide a novel approach to solving PDEs through optimization…

Computational Physics · Physics 2024-11-28 Weiwei Zhang , Wei Suo , Jiahao Song , Wenbo Cao

Physics-informed neural networks (PINNs) have garnered significant interest for their potential in solving partial differential equations (PDEs) that govern a wide range of physical phenomena. By incorporating physical laws into the…

Machine Learning · Computer Science 2026-04-24 Jian Cheng Wong , Isaac Yin Chung Lai , Pao-Hsiung Chiu , Chin Chun Ooi , Abhishek Gupta , Yew-Soon Ong

Physics-Informed Neural Networks (PINNs) have recently been proposed to solve scientific and engineering problems, where physical laws are introduced into neural networks as prior knowledge. With the embedded physical laws, PINNs enable the…

Machine Learning · Computer Science 2022-12-09 Xinle Wu , Dalin Zhang , Miao Zhang , Chenjuan Guo , Shuai Zhao , Yi Zhang , Huai Wang , Bin Yang

Physics-informed neural networks (PINNs) are effective in solving integer-order partial differential equations (PDEs) based on scattered and noisy data. PINNs employ standard feedforward neural networks (NNs) with the PDEs explicitly…

Computational Physics · Physics 2021-11-03 Guofei Pang , Lu Lu , George Em Karniadakis

Differential equations play a pivotal role in modern world ranging from science, engineering, ecology, economics and finance where these can be used to model many physical systems and processes. In this paper, we study two mathematical…

Other Quantitative Biology · Quantitative Biology 2022-09-16 Kanupriya Goswami , Arpana Sharma , Madhu Pruthi , Richa Gupta

We characterize and remedy a failure mode that may arise from multi-scale dynamics with scale imbalances during training of deep neural networks, such as Physics Informed Neural Networks (PINNs). PINNs are popular machine-learning templates…

Machine Learning · Computer Science 2021-07-05 Suryanarayana Maddu , Dominik Sturm , Christian L. Müller , Ivo F. Sbalzarini

Recently, physics-informed neural networks (PINNs) have offered a powerful new paradigm for solving problems relating to differential equations. Compared to classical numerical methods PINNs have several advantages, for example their…

Computational Physics · Physics 2024-06-21 Ben Moseley , Andrew Markham , Tarje Nissen-Meyer

Physiologically Based Pharmacokinetic (PBPK) modeling is a cornerstone of model-informed drug development (MIDD), providing a mechanistic framework to predict drug absorption, distribution, metabolism, and excretion (ADME). Despite its…

Machine Learning · Computer Science 2026-02-24 Shunqi Liu , Han Qiu , Tong Wang