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Related papers: Towards High-Performance and Portable Molecular Do…

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Cloud providers offer a variety of execution platforms in form of bare-metal, VM, and containers. However, due to the pros and cons of each execution platform, choosing the appropriate platform for a specific cloud-based application has…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-06-04 Davood Ghatreh Samani , Chavit Denninnart , Josef Bacik , Mohsen Amini Salehi

GPU-based HPC clusters are attracting more scientific application developers due to their extensive parallelism and energy efficiency. In order to achieve portability among a variety of multi/many core architectures, a popular choice for an…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-04-10 Ali TehraniJamsaz , Alok Mishra , Akash Dutta , Abid M. Malik , Barbara Chapman , Ali Jannesari

The emergence and rapid development of the open RISC-V instruction set architecture opens up new horizons on the way to efficient devices, ranging from existing low-power IoT boards to future high-performance servers. The effective use of…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-04-04 Evgeny Kozinov , Evgeny Vasiliev , Andrey Gorshkov , Valentina Kustikova , Artem Maklaev , Valentin Volokitin , Iosif Meyerov

The increasing use of heterogeneous embedded systems with multi-core CPUs and Graphics Processing Units (GPUs) presents important challenges in effectively exploiting pipeline, task and data-level parallelism to meet throughput requirements…

Signal Processing · Electrical Eng. & Systems 2017-12-01 Shuoxin Lin , Jiahao Wu , Shuvra S. Bhattacharyya

Probabilistic reasoning is an essential tool for robust decision-making systems because of its ability to explicitly handle real-world uncertainty, constraints and causal relations. Consequently, researchers are developing hybrid models by…

Hardware Architecture · Computer Science 2021-03-02 Nimish Shah , Laura I. Galindez Olascoaga , Wannes Meert , Marian Verhelst

Molecular docking is a key computational tool utilized to predict the binding conformations of small molecules to protein targets, which is fundamental in the design of novel drugs. Despite recent advancements in geometric deep…

Biomolecules · Quantitative Biology 2023-12-01 Jiaxian Yan , Zaixi Zhang , Kai Zhang , Qi Liu

Content-defined Chunking (CDC) algorithms dictate the overall space savings that deduplication systems achieve. However, due to their need to scan each file in its entirety, they are slow and often the main performance bottleneck within…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-28 Sreeharsha Udayashankar , Abdelrahman Baba , Samer Al-Kiswany

Optimizing metamaterials with complex geometries is a big challenge. Although an active learning algorithm, combining machine learning (ML), quantum computing, and optical simulation, has emerged as an efficient optimization tool, it still…

Quantum Physics · Physics 2024-05-06 Seongmin Kim , In-Saeng Suh

HPC systems employ a growing variety of compute accelerators with different architectures and from different vendors. Large scientific applications are required to run efficiently across these systems but need to retain a single code-base…

Research processes often rely on high-performance computing (HPC), but HPC is often seen as antithetical to "reproducibility": one would have to choose between software that achieves high performance, and software that can be deployed in a…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-03-16 Ludovic Courtès

Large-scale classical simulation of quantum computers is crucial for benchmarking quantum algorithms, establishing boundaries of quantum advantage and exploring heuristic quantum algorithms. We present a full-state vector simulation…

High-performance computing (HPC) systems and cloud data centers are converging, and containers are becoming the default method of portable software deployment. Yet, while containers simplify software management, they face significant…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-23 Marcin Copik , Eiman Alnuaimi , Alok Kamatar , Valerie Hayot-Sasson , Alberto Madonna , Todd Gamblin , Kyle Chard , Ian Foster , Torsten Hoefler

Molecular docking is a critical computational method in drug discovery used to predict the binding conformation and orientation of a ligand within a protein's binding site. Mapping this challenge onto a graph-based problem, specifically the…

Quantum Physics · Physics 2026-04-27 Mathieu Garrigues , Victor Onofre , Wesley Coelho , S. Acheche

Containers are an emerging technology that hold promise for improving productivity and code portability in scientific computing. We examine Linux container technology for the distribution of a non-trivial scientific computing software stack…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-06-19 Jack S. Hale , Lizao Li , Chris N. Richardson , Garth N. Wells

Performance variability is an important measure for a reliable high performance computing (HPC) system. Performance variability is affected by complicated interactions between numerous factors, such as CPU frequency, the number of…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-12-16 Li Xu , Thomas Lux , Tyler Chang , Bo Li , Yili Hong , Layne Watson , Ali Butt , Danfeng Yao , Kirk Cameron

Dedicated tensor accelerators demonstrate the importance of linear algebra in modern applications. Such accelerators have the potential for impressive performance gains, but require programmers to rewrite code using vendor APIs - a barrier…

Modern microprocessors are equipped with Single Instruction Multiple Data (SIMD) or vector instructions which expose data level parallelism at a fine granularity. Programmers exploit this parallelism by using low-level vector intrinsics in…

Programming Languages · Computer Science 2019-02-11 Charith Mendis , Ajay Jain , Paras Jain , Saman Amarasinghe

Traditional heterogeneous parallel algorithms, designed for heterogeneous clusters of workstations, are based on the assumption that the absolute speed of the processors does not depend on the size of the computational task. This assumption…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-09-15 Alexey Lastovetsky , Ravi Reddy , Vladimir Rychkov , David Clarke

No area of computing is hungrier for performance than High Performance Computing (HPC), the demands of which continue to be a major driver for processor performance and adoption of accelerators, and also advances in memory, storage, and…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-08-18 Pablo Ouro , Unai Lopez-Novoa , Martyn Guest

We provide an overview of the software engineering efforts and their impact in QMCPACK, a production-level ab-initio Quantum Monte Carlo open-source code targeting high-performance computing (HPC) systems. Aspects included are: (i)…