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The search for high-affinity aptamers for targets such as proteins, small molecules, or cancer cells remains a formidable endeavor. Systematic Evolution of Ligands by EXponential Enrichment (SELEX) offers an iterative process to discover…

Biological Physics · Physics 2016-12-30 Fabian Spill , Zohar B. Weinstein , Atena Irani Shemirani , Nga Ho , Darash Desai , Muhammad H. Zaman

Active learning is a branch of machine learning that deals with problems where unlabeled data is abundant yet obtaining labels is expensive. The learning algorithm has the possibility of querying a limited number of samples to obtain the…

Disordered Systems and Neural Networks · Physics 2020-09-04 Hugo Cui , Luca Saglietti , Lenka Zdeborová

Reinforcement learning algorithms commonly seek to optimize policies for solving one particular task. How should we explore an unknown dynamical system such that the estimated model globally approximates the dynamics and allows us to solve…

Machine Learning · Computer Science 2023-10-31 Bhavya Sukhija , Lenart Treven , Cansu Sancaktar , Sebastian Blaes , Stelian Coros , Andreas Krause

Active learning algorithms select a subset of data for annotation to maximize the model performance on a budget. One such algorithm is Expected Gradient Length, which as the name suggests uses the approximate gradient induced per example in…

Computer Vision and Pattern Recognition · Computer Science 2022-06-02 Megh Shukla

This paper explores learning emulators for parameter estimation with uncertainty estimation of high-dimensional dynamical systems. We assume access to a computationally complex simulator that inputs a candidate parameter and outputs a…

Machine Learning · Computer Science 2022-11-04 Ruoxi Jiang , Rebecca Willett

We introduce a class of learning problems where the agent is presented with a series of tasks. Intuitively, if there is relation among those tasks, then the information gained during execution of one task has value for the execution of…

Machine Learning · Computer Science 2012-09-06 Christos Dimitrakakis

In this paper, we analyze the finite sample complexity of stochastic system identification using modern tools from machine learning and statistics. An unknown discrete-time linear system evolves over time under Gaussian noise without…

Machine Learning · Computer Science 2019-03-22 Anastasios Tsiamis , George J. Pappas

This paper considers a single-trajectory system identification problem for linear systems under general nonlinear and/or time-varying policies with i.i.d. random excitation noises. The problem is motivated by safe learning-based control for…

Optimization and Control · Mathematics 2023-06-21 Yingying Li , Tianpeng Zhang , Subhro Das , Jeff Shamma , Na Li

Dynamic ensemble selection systems work by estimating the level of competence of each classifier from a pool of classifiers. Only the most competent ones are selected to classify a given test sample. This is achieved by defining a criterion…

Machine Learning · Computer Science 2020-03-06 Rafael M. O. Cruz , Robert Sabourin , George D. C. Cavalcanti , Tsang Ing Ren

We analyze the problem of learning a single user's preferences in an active learning setting, sequentially and adaptively querying the user over a finite time horizon. Learning is conducted via choice-based queries, where the user selects…

Machine Learning · Statistics 2017-02-27 Stephen N. Pallone , Peter I. Frazier , Shane G. Henderson

Linear dynamical systems are canonical models for learning-based control of plants with uncertain dynamics. The setting consists of a stochastic differential equation that captures the state evolution of the plant understudy, while the true…

Systems and Control · Electrical Eng. & Systems 2022-01-03 Mohamad Kazem Shirani Faradonbeh , Mohamad Sadegh Shirani Faradonbeh

For many tasks of data analysis, we may only have the information of the explanatory variable and the evaluation of the response values are quite expensive. While it is impractical or too costly to obtain the responses of all units, a…

Computation · Statistics 2023-04-07 Wei Zheng , Ting Tian , Xueqin Wang

In many engineered systems, optimization is used for decision making at time-scales ranging from real-time operation to long-term planning. This process often involves solving similar optimization problems over and over again with slightly…

Optimization and Control · Mathematics 2019-01-18 Sidhant Misra , Line Roald , Yeesian Ng

High complexity models are notorious in machine learning for overfitting, a phenomenon in which models well represent data but fail to generalize an underlying data generating process. A typical procedure for circumventing overfitting…

Machine Learning · Statistics 2025-03-11 James Schmidt

We propose a framework to analyze stability for a class of linear non-autonomous hybrid systems, where the continuous evolution of solutions is governed by an ordinary differential equation and the instantaneous changes are governed by a…

Optimization and Control · Mathematics 2023-01-24 Adnane Saoud , Mohamed Maghenem , Antonio Loría , Ricardo G. Sanfelice

How should we gather information to make effective decisions? We address Bayesian active learning and experimental design problems, where we sequentially select tests to reduce uncertainty about a set of hypotheses. Instead of minimizing…

Machine Learning · Computer Science 2014-02-25 Shervin Javdani , Yuxin Chen , Amin Karbasi , Andreas Krause , J. Andrew Bagnell , Siddhartha Srinivasa

This paper presents a discrete-time nonlinear system identification method while satisfying the stability and safety properties of the system with high probability. An Extreme Learning Machine (ELM) is used with a Gaussian assumption on the…

Systems and Control · Electrical Eng. & Systems 2022-10-04 Iman Salehi , Tyler Taplin , Ashwin P. Dani

Adversarial example (AE) is an attack method for machine learning, which is crafted by adding imperceptible perturbation to the data inducing misclassification. In the current paper, we investigated the upper bound of the probability of…

Machine Learning · Computer Science 2025-03-20 Hiroaki Maeshima , Akira Otsuka

A fundamental problem in adversarial machine learning is to quantify how much training data is needed in the presence of evasion attacks. In this paper we address this issue within the framework of PAC learning, focusing on the class of…

Machine Learning · Computer Science 2022-05-13 Pascale Gourdeau , Varun Kanade , Marta Kwiatkowska , James Worrell

This paper presents an information-theoretic framework for unifying active learning problems: level set estimation (LSE), Bayesian optimization (BO), and their generalized variant. We first introduce a novel active learning criterion that…

Machine Learning · Computer Science 2020-12-22 Quoc Phong Nguyen , Bryan Kian Hsiang Low , Patrick Jaillet
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