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Many existing models for clinical trial outcome prediction are optimized using task-specific loss functions on trial phase-specific data. While this scheme may boost prediction for common diseases and drugs, it can hinder learning of…

Machine Learning · Computer Science 2025-05-27 Yiqing Zhang , Xiaozhong Liu , Fabricio Murai

Reinforcement learning has become a cornerstone technique for developing reasoning models in complex tasks, ranging from mathematical problem-solving to imaginary reasoning. The optimization of these models typically relies on policy…

Machine Learning · Computer Science 2026-02-11 Qingnan Ren , Shiting Huang , Zhen Fang , Zehui Chen , Lin Chen , Lijun Li , Feng Zhao

Adversarial approaches, which intentionally challenge machine learning models by generating difficult examples, are increasingly being adopted to improve machine learning interatomic potentials (MLIPs). While already providing great…

This paper investigates the problem of selecting variables in regression-type models for an "instrumental" setting. Our study is motivated by empirically verifying the conditional convergence hypothesis used in the economical literature…

Statistics Theory · Mathematics 2015-03-19 Mathilde Mougeot , Dominique Picard , Karine Tribouley

We propose DRAGO, a novel approach for continual model-based reinforcement learning aimed at improving the incremental development of world models across a sequence of tasks that differ in their reward functions but not the state space or…

Machine Learning · Computer Science 2025-06-09 Yixiang Sun , Haotian Fu , Michael Littman , George Konidaris

While Large Language Models (LLMs) have demonstrated remarkable fluency in educational dialogues, most generative tutors primarily operate through intuitive, single-pass generation. This reliance on fast thinking precludes a dedicated…

Artificial Intelligence · Computer Science 2026-03-31 Yuang Wei , Ruijia Li , Bo Jiang

Reinforcement learning has been widely applied to enhance the reasoning capabilities of large language models. Extending the inference limits of smaller models has become a prominent research focus. However, algorithms such as Group…

Artificial Intelligence · Computer Science 2025-10-10 Hao Wu , Wei Liu

Learning to Optimize (L2O) has drawn increasing attention as it often remarkably accelerates the optimization procedure of complex tasks by ``overfitting" specific task type, leading to enhanced performance compared to analytical…

Machine Learning · Computer Science 2023-03-02 Junjie Yang , Xuxi Chen , Tianlong Chen , Zhangyang Wang , Yingbin Liang

Large language models (LLMs) have shown remarkable emergent capabilities, transforming the execution of functional tasks by leveraging external tools for complex problems that require specialized processing or up-to-date data. While…

Computation and Language · Computer Science 2025-08-22 Wenjun Li , Dexun Li , Kuicai Dong , Cong Zhang , Hao Zhang , Weiwen Liu , Yasheng Wang , Ruiming Tang , Yong Liu

Audio and omni-modal large language models exhibit impressive cross-modal reasoning capabilities. However, applying standard reinforcement learning post-training algorithms to these models exposes a critical structural vulnerability:…

Computation and Language · Computer Science 2026-05-28 Cihan Xiao , Yiwen Shao , Chenxing Li , Xiang He , Zhenwen Liang , Steve Yves , Sanjeev Khudanpur , Liefeng Bo

Reinforcement learning algorithms such as group-relative policy optimization (GRPO) have shown strong potential for improving the mathematical reasoning capabilities of large language models. While a growing body of work seeks to improve…

Machine Learning · Computer Science 2026-05-12 Wenquan Lu , Hai Huang , Enqi Liu , Randall Balestriero

In this paper, we investigate the power of online learning in stochastic network optimization with unknown system statistics {\it a priori}. We are interested in understanding how information and learning can be efficiently incorporated…

Optimization and Control · Mathematics 2014-07-30 Longbo Huang , Xin Liu , Xiaohong Hao

Large reasoning models (LRMs) have demonstrated strong performance on complex reasoning tasks, but often suffer from overthinking, generating redundant content regardless of task difficulty. Inspired by the dual process theory in cognitive…

Artificial Intelligence · Computer Science 2025-05-26 Xiaoxue Cheng , Junyi Li , Zhenduo Zhang , Xinyu Tang , Wayne Xin Zhao , Xinyu Kong , Zhiqiang Zhang

Topology control for power grid operation is a challenging sequential decision making problem because the action space grows combinatorially with the size of the grid and action evaluation through simulation is computationally expensive. We…

Machine Learning · Computer Science 2026-04-03 Pantelis Dogoulis , Maxime Cordy

Existing Bayesian Optimization (BO) methods typically balance exploration and exploitation to optimize costly objective functions. However, these methods often suffer from a significant one-step bias, which may lead to convergence towards…

Machine Learning · Computer Science 2025-10-23 Ruiyao Miao , Junren Xiao , Shiya Tsang , Hui Xiong , Yingnian Wu

Power-law scaling indicates that large-scale training with uniform sampling is prohibitively slow. Active learning methods aim to increase data efficiency by prioritizing learning on the most relevant examples. Despite their appeal, these…

Artificial Intelligence · Computer Science 2024-10-17 Talfan Evans , Shreya Pathak , Hamza Merzic , Jonathan Schwarz , Ryutaro Tanno , Olivier J. Henaff

Adaptive designs are increasingly used in clinical trials and online experiments to improve participant outcomes by dynamically updating treatment allocation as data accumulate. In practice, experimenters often consider multiple candidate…

Methodology · Statistics 2026-04-08 Wenxin Zhang , Aaron Hudson , Maya Petersen , Mark van der Laan

The ability to make decisions based on data, with its inherent uncertainties and variability, is a complex and vital skill in the modern world. The need for such quantitative critical thinking occurs in many different contexts, and while it…

Physics Education · Physics 2015-08-21 N. G. Holmes , Carl E. Wieman , D. A. Bonn

The reproducibility crisis has led to an increasing number of replication studies being conducted. Sample sizes for replication studies are often calculated using conditional power based on the effect estimate from the original study.…

Methodology · Statistics 2022-10-19 Charlotte Micheloud , Leonhard Held

Due to recent breakthroughs, reinforcement learning (RL) has demonstrated impressive performance in challenging sequential decision-making problems. However, an open question is how to make RL cope with partial observability which is…

Machine Learning · Computer Science 2021-04-23 Stephan Weigand , Pascal Klink , Jan Peters , Joni Pajarinen