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Machine learning methods have shown promise in predicting molecular properties, and given sufficient training data machine learning approaches can enable rapid high-throughput virtual screening of large libraries of compounds. Graph-based…

Recently, message-passing Neural networks (MPNN) provide a promising tool for dealing with molecular graphs and have achieved remarkable success in facilitating the discovery and materials design with desired properties. However, the…

Materials Science · Physics 2023-07-12 Hai Lan , Xian Wei

Supervised learning on molecules has incredible potential to be useful in chemistry, drug discovery, and materials science. Luckily, several promising and closely related neural network models invariant to molecular symmetries have already…

Machine Learning · Computer Science 2017-06-14 Justin Gilmer , Samuel S. Schoenholz , Patrick F. Riley , Oriol Vinyals , George E. Dahl

Message-passing neural networks (MPNNs) are widely used for molecular property prediction, but their deployment as monolithic architectures makes it difficult to identify how specific message-passing operators affect performance. We present…

Materials Science · Physics 2026-05-29 Panyu Jiao , Shuizhou Chen , Yiheng Shen , Yuyang Wang , Runhai Ouyang , Wei Xie

Message passing neural networks (MPNNs) operate on graphs by exchanging information between neigbouring nodes. MPNNs have been successfully applied to various node-, edge-, and graph-level tasks in areas like molecular science, computer…

Machine Learning · Computer Science 2025-11-05 Lisi Qarkaxhija , Anatol E. Wegner , Ingo Scholtes

Constructing appropriate representations of molecules lies at the core of numerous tasks such as material science, chemistry and drug designs. Recent researches abstract molecules as attributed graphs and employ graph neural networks (GNN)…

Machine Learning · Computer Science 2021-07-29 Jianwen Chen , Shuangjia Zheng , Ying Song , Jiahua Rao , Yuedong Yang

Message passing neural networks have recently evolved into a state-of-the-art approach to representation learning on graphs. Existing methods perform synchronous message passing along all edges in multiple subsequent rounds and consequently…

Machine Learning · Computer Science 2020-12-21 Julian Busch , Jiaxing Pi , Thomas Seidl

Message passing neural networks have become a method of choice for learning on graphs, in particular the prediction of chemical properties and the acceleration of molecular dynamics studies. While they readily scale to large training data…

Machine Learning · Computer Science 2021-06-08 Kristof T. Schütt , Oliver T. Unke , Michael Gastegger

A molecule is a complex of heterogeneous components, and the spatial arrangements of these components determine the whole molecular properties and characteristics. With the advent of deep learning in computational chemistry, several studies…

Machine Learning · Computer Science 2021-06-15 Jeonghee Jo , Bumju Kwak , Byunghan Lee , Sungroh Yoon

We present GPS++, a hybrid Message Passing Neural Network / Graph Transformer model for molecular property prediction. Our model integrates a well-tuned local message passing component and biased global attention with other key ideas from…

Modelling long-range dependencies is critical for scene understanding tasks in computer vision. Although convolution neural networks (CNNs) have excelled in many vision tasks, they are still limited in capturing long-range structured…

Computer Vision and Pattern Recognition · Computer Science 2022-09-21 Li Zhang , Mohan Chen , Anurag Arnab , Xiangyang Xue , Philip H. S. Torr

The quest for efficient and robust deep learning models for molecular systems representation is increasingly critical in scientific exploration. The advent of message passing neural networks has marked a transformative era in graph-based…

Computational Physics · Physics 2026-01-05 Jian Chang , Shuze Zhu

Message passing neural networks (MPNNs) have emerged as go-to models for learning on graph-structured data in the past decade. Despite their effectiveness, most of such models still incur severe issues such as over-smoothing and…

Machine Learning · Computer Science 2025-11-26 Haoran Zheng , Renchi Yang , Yubo Zhou , Jianliang Xu

We propose Scalable Message Passing Neural Networks (SMPNNs) and demonstrate that, by integrating standard convolutional message passing into a Pre-Layer Normalization Transformer-style block instead of attention, we can produce…

Machine Learning · Computer Science 2026-03-11 Haitz Sáez de Ocáriz Borde , Artem Lukoianov , Anastasis Kratsios , Michael Bronstein , Xiaowen Dong

Message Passing Neural Networks (MPNNs) have emerged as the {\em de facto} standard in graph representation learning. However, when it comes to link prediction, they often struggle, surpassed by simple heuristics such as Common Neighbor…

Machine Learning · Computer Science 2024-10-15 Kaiwen Dong , Zhichun Guo , Nitesh V. Chawla

In this work we propose Pathfinder Discovery Networks (PDNs), a method for jointly learning a message passing graph over a multiplex network with a downstream semi-supervised model. PDNs inductively learn an aggregated weight for each edge,…

Machine Learning · Computer Science 2021-02-18 Benedek Rozemberczki , Peter Englert , Amol Kapoor , Martin Blais , Bryan Perozzi

Molecular representation learning (MRL) has long been crucial in the fields of drug discovery and materials science, and it has made significant progress due to the development of natural language processing (NLP) and graph neural networks…

Information Theory · Computer Science 2023-05-25 Chen Gong , Yvon Maday

Message-passing graph neural networks (MPNNs) emerged as powerful tools for processing graph-structured input. However, they operate on a fixed input graph structure, ignoring potential noise and missing information. Furthermore, their…

Machine Learning · Computer Science 2024-03-27 Chendi Qian , Andrei Manolache , Kareem Ahmed , Zhe Zeng , Guy Van den Broeck , Mathias Niepert , Christopher Morris

We consider representation learning of 3D molecular graphs in which each atom is associated with a spatial position in 3D. This is an under-explored area of research, and a principled message passing framework is currently lacking. In this…

Machine Learning · Computer Science 2022-11-28 Yi Liu , Limei Wang , Meng Liu , Xuan Zhang , Bora Oztekin , Shuiwang Ji

This study follows many classical approaches to multi-object tracking (MOT) that model the problem using dynamic graphical data structures, and adapts this formulation to make it amenable to modern neural networks. Our main contributions in…

Computer Vision and Pattern Recognition · Computer Science 2021-05-10 Akshay Rangesh , Pranav Maheshwari , Mez Gebre , Siddhesh Mhatre , Vahid Ramezani , Mohan M. Trivedi
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