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Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

Automated fact-checking, using machine learning to verify claims, has grown vital as misinformation spreads beyond human fact-checking capacity. Large Language Models (LLMs) like GPT-4 are increasingly trusted to write academic papers,…

Computation and Language · Computer Science 2024-02-08 Dorian Quelle , Alexandre Bovet

Large language models (LLMs) have demonstrated great potential for domain-specific applications, such as the law domain. However, recent disputes over GPT-4's law evaluation raise questions concerning their performance in real-world legal…

Computation and Language · Computer Science 2023-10-19 Ruihao Shui , Yixin Cao , Xiang Wang , Tat-Seng Chua

Large language models (LLMs) are increasingly being used to generate comprehensive, knowledge-intensive reports. However, while these models are trained on diverse academic papers and reports, they are not exposed to the reasoning processes…

Computation and Language · Computer Science 2026-03-31 Xinran Zhao , Aakanksha Naik , Jay DeYoung , Joseph Chee Chang , Jena D. Hwang , Tongshuang Wu , Varsha Kishore

The rise of large language models (LLMs) is revolutionizing information retrieval, question answering, summarization, and code generation tasks. However, in addition to confidently presenting factually inaccurate information at times (known…

Artificial Intelligence · Computer Science 2023-04-26 Henry Gilbert , Michael Sandborn , Douglas C. Schmidt , Jesse Spencer-Smith , Jules White

Large Language Models (LLMs) are increasingly being explored for clinical question answering and decision support, yet safe deployment critically requires reliable handling of patient measurements in heterogeneous clinical notes. Existing…

Computation and Language · Computer Science 2026-04-16 Minh-Vuong Nguyen , Fatemeh Shiri , Zhuang Li , Karin Verspoor

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Large Language Models (LLMs) have revolutionized inference across diverse natural language tasks, with larger models performing better but at higher computational costs. We propose a confidence-driven strategy that dynamically selects the…

Computation and Language · Computer Science 2026-02-26 Bo-Wei Chen , Chung-Chi Chen , An-Zi Yen

Collecting labeled datasets in finance is challenging due to scarcity of domain experts and higher cost of employing them. While Large Language Models (LLMs) have demonstrated remarkable performance in data annotation tasks on general…

Computation and Language · Computer Science 2024-03-28 Toyin Aguda , Suchetha Siddagangappa , Elena Kochkina , Simerjot Kaur , Dongsheng Wang , Charese Smiley , Sameena Shah

Large Language Models (LLMs) are widely used in critical fields such as healthcare, education, and finance due to their remarkable proficiency in various language-related tasks. However, LLMs are prone to generating factually incorrect…

Computation and Language · Computer Science 2023-11-27 Muneeswaran I , Shreya Saxena , Siva Prasad , M V Sai Prakash , Advaith Shankar , Varun V , Vishal Vaddina , Saisubramaniam Gopalakrishnan

Large Language Models (LLMs) have revolutionized the field of Natural Language Processing thanks to their ability to reuse knowledge acquired on massive text corpora on a wide variety of downstream tasks, with minimal (if any) tuning steps.…

Computation and Language · Computer Science 2024-07-12 Flavio Petruzzellis , Alberto Testolin , Alessandro Sperduti

Large language models (LLMs) have shown promise in medical question answering, yet they often overlook the domain-specific expertise that professionals depend on, such as the clinical subject areas (e.g., trauma, airway) and the…

Computation and Language · Computer Science 2025-11-20 Xueren Ge , Sahil Murtaza , Anthony Cortez , Homa Alemzadeh

The advancement of Large Language Models (LLMs) has greatly improved our ability to process complex language. However, accurately detecting logical fallacies remains a significant challenge. This study presents a novel and effective prompt…

Artificial Intelligence · Computer Science 2025-04-01 Jiwon Jeong , Hyeju Jang , Hogun Park

Machine learning (ML) holds great promise for clinical applications but is often hindered by limited access to high-quality data due to privacy concerns, high costs, and long timelines associated with clinical trials. While large language…

Computation and Language · Computer Science 2026-03-27 Zerui Xu , Fang Wu , Yingzhou Lu , Yuanyuan Zhang , Yue Zhao

Data elicitation from human participants is one of the core data collection strategies used in empirical linguistic research. The amount of participants in such studies may vary considerably, ranging from a handful to crowdsourcing…

Computation and Language · Computer Science 2025-02-17 Iris Ferrazzo

Numerous decision-making tasks require estimating causal effects under interventions on different parts of a system. As practitioners consider using large language models (LLMs) to automate decisions, studying their causal reasoning…

Machine Learning · Computer Science 2024-12-24 Tejas Kasetty , Divyat Mahajan , Gintare Karolina Dziugaite , Alexandre Drouin , Dhanya Sridhar

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

Large Language Models (LLMs) can be tasked with scoring texts according to pre-defined criteria and on a defined scale, but there is no recognised optimal prompting strategy for this. This article focuses on the task of LLMs scoring journal…

Digital Libraries · Computer Science 2025-12-02 Mike Thelwall

Large Language Models (LLMs) like GPT-4o can help automate text classification tasks at low cost and scale. However, there are major concerns about the validity and reliability of LLM outputs. By contrast, human coding is generally more…

Computation and Language · Computer Science 2025-01-17 Conrad Borchers , Danielle R. Thomas , Jionghao Lin , Ralph Abboud , Kenneth R. Koedinger

Large Language Models (LLMs), originally developed for natural language processing (NLP), have demonstrated the potential to generalize across modalities and domains. With their in-context learning (ICL) capabilities, LLMs can perform…

Artificial Intelligence · Computer Science 2025-08-26 Nikolaos Pavlidis , Vasilis Perifanis , Symeon Symeonidis , Pavlos S. Efraimidis