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Adaptive designs are increasingly used in clinical trials and online experiments to improve participant outcomes by dynamically updating treatment allocation as data accumulate. In practice, experimenters often consider multiple candidate…

Methodology · Statistics 2026-04-08 Wenxin Zhang , Aaron Hudson , Maya Petersen , Mark van der Laan

A fundamental task in science is to design experiments that yield valuable insights about the system under study. Mathematically, these insights can be represented as a utility or risk function that shapes the value of conducting each…

Machine Learning · Computer Science 2022-10-24 Christopher Tosh , Mauricio Tec , Wesley Tansey

We provide an approach to exploratory data analysis in matched observational studies with a single intervention and multiple endpoints. In such settings, the researcher would like to explore evidence for actual treatment effects among these…

Methodology · Statistics 2025-12-10 Mengqi Lin , Colin Fogarty

A basic feature of many field experiments is that investigators are only able to randomize clusters of individuals--such as households, communities, firms, medical practices, schools or classrooms--even when the individual is the unit of…

Methodology · Statistics 2009-10-21 Kosuke Imai , Gary King , Clayton Nall

Most prior work on active learning of classifiers has focused on sequentially selecting one unlabeled example at a time to be labeled in order to reduce the overall labeling effort. In many scenarios, however, it is desirable to label an…

Machine Learning · Computer Science 2012-07-03 Javad Azimi , Alan Fern , Xiaoli Zhang-Fern , Glencora Borradaile , Brent Heeringa

Gathering training data is a key step of any supervised learning task, and it is both critical and expensive. Critical, because the quantity and quality of the training data has a high impact on the performance of the learned function.…

Data Structures and Algorithms · Computer Science 2021-10-28 Quentin Lutz , Élie de Panafieu , Alex Scott , Maya Stein

The simultaneous application of multiple treatments is increasingly common in many fields, such as healthcare and marketing. In such scenarios, it is important to estimate the single treatment effects and the interaction treatment effects…

Methodology · Statistics 2025-11-14 Yuki Murakami , Takumi Hattori , Kohsuke Kubota

We present a general-purpose active learning scheme for data in metric spaces. The algorithm maintains a collection of neighborhoods of different sizes and uses label queries to identify those that have a strong bias towards one particular…

Machine Learning · Computer Science 2023-03-07 Sanjoy Dasgupta , Yoav Freund

In this paper, we present a new way of matching in observational studies that overcomes three limitations of existing matching approaches. First, it directly balances covariates with multi-valued treatments without requiring the generalized…

Applications · Statistics 2019-07-11 Magdalena Bennett , Juan Pablo Vielma , Jose R. Zubizarreta

When pre-processing observational data via matching, we seek to approximate each unit with maximally similar peers that had an alternative treatment status--essentially replicating a randomized block design. However, as one considers a…

Econometrics · Economics 2019-05-30 Gentry Johnson , Brian Quistorff , Matt Goldman

Modern computing and communication technologies can make data collection procedures very efficient. However, our ability to analyze large data sets and/or to extract information out from them is hard-pressed to keep up with our capacities…

Machine Learning · Statistics 2019-01-30 Zhanfeng Wang , Yumi Kwon , Yuan-chin Ivan Chang

Classification is an important task in many fields including biomedical research and machine learning. Traditionally, a classification rule is constructed based a bunch of labeled data. Recently, due to technological innovation and…

Methodology · Statistics 2014-06-19 Jing Wang , Eunsik Park , Yuan-chin Ivan Chang

Experiments deliver credible treatment-effect estimates but, because they are costly, are often restricted to specific sites, small populations, or particular mechanisms. A common practice across several fields is therefore to combine…

Econometrics · Economics 2025-12-30 Aristotelis Epanomeritakis , Davide Viviano

We propose using active learning based techniques to further improve the state-of-the-art semi-supervised learning MixMatch algorithm. We provide a thorough empirical evaluation of several active-learning and baseline methods, which…

Machine Learning · Computer Science 2019-12-04 Shuang Song , David Berthelot , Afshin Rostamizadeh

In this book chapter, we discuss recent advances in data-driven approaches for inverse problems. In particular, we focus on the \emph{paired autoencoder} framework, which has proven to be a powerful tool for solving inverse problems in…

Machine Learning · Computer Science 2025-08-20 Matthias Chung , Bas Peters , Michael Solomon

In collaborative active learning, where multiple agents try to learn labels from a common hypothesis, we introduce an innovative framework for incentivized collaboration. Here, rational agents aim to obtain labels for their data sets while…

Computer Science and Game Theory · Computer Science 2023-11-02 Lee Cohen , Han Shao

Existing approaches to active learning maximize the system performance by sampling unlabeled instances for annotation that yield the most efficient training. However, when active learning is integrated with an end-user application, this can…

Computation and Language · Computer Science 2020-05-13 Ji-Ung Lee , Christian M. Meyer , Iryna Gurevych

Combinatorial optimization algorithm is essential in computer-aided drug design by progressively exploring chemical space to design lead compounds with high affinity to target protein. However current methods face inherent challenges in…

Biomolecules · Quantitative Biology 2025-07-23 Hao Tuo , Yan Li , Xuanning Hu , Haishi Zhao , Xueyan Liu , Bo Yang

Pharmaceutical targeting is one of key inputs for making sales and marketing strategy planning. Targeting list is built on predicting physician's sales potential of certain type of patient. In this paper, we present a time-sensitive…

Machine Learning · Computer Science 2018-12-04 Weiyu Huang , Yunlong Wang , Li Zhou , Emily Zhao , Yilian Yuan , Alejandro Ribero

The advancement of novel combinatorial CRISPR screening technologies enables the identification of synergistic gene combinations on a large scale. This is crucial for developing novel and effective combination therapies, but the…

Genomics · Quantitative Biology 2024-12-12 Jason Qin , Hans-Hermann Wessels , Carlos Fernandez-Granda , Yuhan Hao