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The rise of large language models (LLMs) has transformed healthcare by offering clinical guidance, yet their direct deployment to patients poses safety risks due to limited domain expertise. To mitigate this, we propose repositioning LLMs…

Computation and Language · Computer Science 2025-10-14 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Prayag Tiwari , Xiang Wan , Feng Jiang , Benyou Wang

Large Language Models (LLMs) are transforming mental health care by enhancing accessibility, personalization, and efficiency in therapeutic interventions. These AI-driven tools empower mental health professionals with real-time support,…

Computers and Society · Computer Science 2025-01-22 Hari Mohan Pandey

Emerging efforts in AI alignment seek to broaden participation in shaping model behavior by eliciting and integrating collective input into a policy for model finetuning. While pluralistic, these processes are often linear and do not allow…

Human-Computer Interaction · Computer Science 2025-03-18 K. J. Kevin Feng , Inyoung Cheong , Quan Ze Chen , Amy X. Zhang

Recent advances in medical multi-modal models focus on specialized image analysis like dermatology, pathology, or radiology. However, they do not fully capture the complexity of real-world clinical diagnostics, which involve heterogeneous…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Jiao Xu , Junwei Liu , Jiangwei Lao , Qi Zhu , Yunpeng Zhao , Congyun Jin , Shinan Liu , Zhihong Lu , Lihe Zhang , Xin Chen , Jian Wang , Ping Wang

Existing work on the alignment problem has focused mainly on (1) qualitative descriptions of the alignment problem; (2) attempting to align AI actions with human interests by focusing on value specification and learning; and/or (3) focusing…

Multiagent Systems · Computer Science 2025-06-03 Aidan Kierans , Avijit Ghosh , Hananel Hazan , Shiri Dori-Hacohen

Domain shift, the mismatch between training and testing data characteristics, causes significant degradation in the predictive performance in multi-source imaging scenarios. In medical imaging, the heterogeneity of population, scanners and…

Machine Learning · Computer Science 2021-12-21 Rongguang Wang , Pratik Chaudhari , Christos Davatzikos

Equity is widely held to be fundamental to the ethics of healthcare. In the context of clinical decision-making, it rests on the comparative fidelity of the intelligence -- evidence-based or intuitive -- guiding the management of each…

While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis. Existing methods typically rely on static, linear mappings…

Computation and Language · Computer Science 2026-05-28 Zhuohan Ge , Haoyang Li , Yubo Wang , Nicole Hu , Chen Jason Zhang , Qing Li

Large-scale EHR prediction across institutions is hindered by substantial heterogeneity in schemas and code systems. Although Common Data Models (CDMs) can standardize records for multi-institutional learning, the manual harmonization and…

Computation and Language · Computer Science 2026-04-02 Kyunghoon Hur , Heeyoung Kwak , Jinsu Jang , Nakhwan Kim , Edward Choi

The value alignment problem for artificial intelligence (AI) is often framed as a purely technical or normative challenge, sometimes focused on hypothetical future systems. I argue that the problem is better understood as a structural…

Computers and Society · Computer Science 2026-04-23 Travis LaCroix

The deployment of large language models (LLMs) within the healthcare sector has sparked both enthusiasm and apprehension. These models exhibit the remarkable capability to provide proficient responses to free-text queries, demonstrating a…

Computation and Language · Computer Science 2024-07-09 Zabir Al Nazi , Wei Peng

Large Language Models (LLMs) have demonstrated remarkable versatility in recent years, offering potential applications across specialized domains such as healthcare and medicine. Despite the availability of various open-source LLMs tailored…

Computation and Language · Computer Science 2024-07-18 Yanis Labrak , Adrien Bazoge , Emmanuel Morin , Pierre-Antoine Gourraud , Mickael Rouvier , Richard Dufour

The emergence of advanced reasoning capabilities in Large Language Models (LLMs) marks a transformative development in healthcare applications. Beyond merely expanding functional capabilities, these reasoning mechanisms enhance decision…

Artificial Intelligence · Computer Science 2025-08-27 Armin Berger , Sarthak Khanna , David Berghaus , Rafet Sifa

HealthBranches is a novel benchmark dataset for medical Question-Answering (Q&A), specifically designed to evaluate complex reasoning in Large Language Models (LLMs). This dataset is generated through a semi-automated pipeline that…

Computation and Language · Computer Science 2025-08-12 Cristian Cosentino , Annamaria Defilippo , Marco Dossena , Christopher Irwin , Sara Joubbi , Pietro Liò

Recent advancements in large language models have demonstrated their potential in numerous medical applications, particularly in automating clinical trial matching for translational research and enhancing medical question answering for…

Computation and Language · Computer Science 2024-10-15 Yuelyu Ji , Wenhe Ma , Sonish Sivarajkumar , Hang Zhang , Eugene Mathew Sadhu , Zhuochun Li , Xizhi Wu , Shyam Visweswaran , Yanshan Wang

Large language models (LLMs) are increasingly being used as decision aids. However, users have diverse values and preferences that can affect their decision-making, which requires novel methods for LLM alignment and personalization.…

Computation and Language · Computer Science 2025-07-15 Bharadwaj Ravichandran , David Joy , Paul Elliott , Brian Hu , Jadie Adams , Christopher Funk , Emily Veenhuis , Anthony Hoogs , Arslan Basharat

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Large language models (LLMs) have been increasingly adopted to support patients' healthcare-seeking in recent years. While prior patient-centered studies have examined the capabilities and experience of LLM-based tools in specific…

Human-Computer Interaction · Computer Science 2026-02-25 Yancheng Cao , Yishu Ji , Chris Yue Fu , Sahiti Dharmavaram , Meghan Turchioe , Natalie C Benda , Lena Mamykina , Yuling Sun , Xuhai "Orson" Xu

Limited access to mental healthcare, extended wait times, and increasing capabilities of Large Language Models (LLMs) has led individuals to turn to LLMs for fulfilling their mental health needs. However, examining the multi-turn mental…

Computation and Language · Computer Science 2025-05-29 Mohit Chandra , Siddharth Sriraman , Harneet Singh Khanuja , Yiqiao Jin , Munmun De Choudhury

This paper explores the advancements and applications of language models in healthcare, focusing on their clinical use cases. It examines the evolution from early encoder-based systems requiring extensive fine-tuning to state-of-the-art…

Artificial Intelligence · Computer Science 2025-05-12 Nikita Neveditsin , Pawan Lingras , Vijay Mago
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