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Related papers: Pluralistic Alignment for Healthcare: A Role-Drive…

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Alignment techniques have become central to ensuring that Large Language Models (LLMs) generate outputs consistent with human values. However, existing alignment paradigms often model an averaged or monolithic preference, failing to account…

Computation and Language · Computer Science 2025-06-03 Anudeex Shetty , Amin Beheshti , Mark Dras , Usman Naseem

Pluralistic alignment is concerned with ensuring that an AI system's objectives and behaviors are in harmony with the diversity of human values and perspectives. In this paper we study the notion of pluralistic alignment in the context of…

Artificial Intelligence · Computer Science 2024-11-19 Parand A. Alamdari , Toryn Q. Klassen , Rodrigo Toro Icarte , Sheila A. McIlraith

With increased power and prevalence of AI systems, it is ever more critical that AI systems are designed to serve all, i.e., people with diverse values and perspectives. However, aligning models to serve pluralistic human values remains an…

Large language models (LLMs) are currently aligned using techniques such as reinforcement learning from human feedback (RLHF). However, these methods use scalar rewards that can only reflect user preferences on average. Pluralistic…

Computation and Language · Computer Science 2025-08-13 Jadie Adams , Brian Hu , Emily Veenhuis , David Joy , Bharadwaj Ravichandran , Aaron Bray , Anthony Hoogs , Arslan Basharat

As large language models are increasingly used in high-stakes domains, it is essential that their outputs reflect not average} human preference, rather range of varying perspectives. Achieving such pluralism, however, remains challenging.…

Computation and Language · Computer Science 2026-01-21 Shenyan Zheng , Jiayou Zhong , Anudeex Shetty , Heng Ji , Preslav Nakov , Usman Naseem

While existing alignment paradigms have been integral in developing large language models (LLMs), LLMs often learn an averaged human preference and struggle to model diverse preferences across cultures, demographics, and communities. We…

Computation and Language · Computer Science 2024-10-14 Shangbin Feng , Taylor Sorensen , Yuhan Liu , Jillian Fisher , Chan Young Park , Yejin Choi , Yulia Tsvetkov

Large language models (LLMs) hold promise for transforming healthcare, from streamlining administrative and clinical workflows to enriching patient engagement and advancing clinical decision-making. However, their successful integration…

Computers and Society · Computer Science 2025-04-04 Mohammed Al-Garadi , Tushar Mungle , Abdulaziz Ahmed , Abeed Sarker , Zhuqi Miao , Michael E. Matheny

Data in the healthcare domain arise from a variety of sources and modalities, such as x-ray images, continuous measurements, and clinical notes. Medical practitioners integrate these diverse data types daily to make informed and accurate…

Machine Learning · Computer Science 2024-08-14 Liv Björkdahl , Oskar Pauli , Johan Östman , Chiara Ceccobello , Sara Lundell , Magnus Kjellberg

Although large language models (LLMs) demonstrate expert-level medical knowledge, aligning their open-ended outputs with fine-grained clinician preferences remains challenging. Existing methods often rely on coarse objectives or unreliable…

Artificial Intelligence · Computer Science 2026-02-12 Shiwei Lyu , Xidong Wang , Lei Liu , Hao Zhu , Chaohe Zhang , Jian Wang , Jinjie Gu , Benyou Wang , Yue Shen

The wide exploration of large language models (LLMs) raises the awareness of alignment between healthcare stakeholder preferences and model outputs. This alignment becomes a crucial foundation to empower the healthcare workflow effectively,…

Computers and Society · Computer Science 2025-05-07 Kexin Ding , Mu Zhou , Akshay Chaudhari , Shaoting Zhang , Dimitris N. Metaxas

While reinforcement learning for large language model alignment has progressed rapidly in recent years, transferring these paradigms to high-stakes medical question answering reveals a fundamental paradigm mismatch. Reinforcement Learning…

Artificial Intelligence · Computer Science 2026-03-03 Tianxiang Xu , Jiayi Liu , Yixuan Tong , Jialu Xu , Yunqing Wei , Kaiwen Feng , PanPan Hou , Kangping Yin , Jiyuan Hu , Hao Zhou , Zhenxin Ma , Jian Xu , Guanjun Jiang

This paper studies the performance of large language models (LLMs), particularly regarding demographic fairness, in solving real-world healthcare tasks. We evaluate state-of-the-art LLMs with three prevalent learning frameworks across six…

Computation and Language · Computer Science 2024-12-10 Yue Zhou , Barbara Di Eugenio , Lu Cheng

Modeling & Simulation (M&S) approaches such as agent-based models hold significant potential to support decision-making activities in health, with recent examples including the adoption of vaccines, and a vast literature on healthy eating…

Artificial Intelligence · Computer Science 2025-09-08 Philippe J. Giabbanelli , Ameeta Agrawal

Foundation models are becoming valuable tools in medicine. Yet despite their promise, the best way to leverage Large Language Models (LLMs) in complex medical tasks remains an open question. We introduce a novel multi-agent framework, named…

Computation and Language · Computer Science 2024-10-31 Yubin Kim , Chanwoo Park , Hyewon Jeong , Yik Siu Chan , Xuhai Xu , Daniel McDuff , Hyeonhoon Lee , Marzyeh Ghassemi , Cynthia Breazeal , Hae Won Park

Large language models (LLMs) face challenges in aligning with diverse cultural values despite their remarkable performance in generation, which stems from inherent monocultural biases and difficulties in capturing nuanced cultural…

Computation and Language · Computer Science 2026-01-05 Jiahao Yuan , Zixiang Di , Shangzixin Zhao , Zhiqing Cui , Hanqing Wang , Guisong Yang , Usman Naseem

The modeling of complex systems such as ecological or socio-economic systems can be very challenging. Although various modeling approaches exist, they are generally not compatible and mutually consistent, and empirical data often do not…

Physics and Society · Physics 2010-07-19 Dirk Helbing

Large language models (LLMs), despite their remarkable progress across various general domains, encounter significant barriers in medicine and healthcare. This field faces unique challenges such as domain-specific terminologies and…

Computation and Language · Computer Science 2024-06-06 Xiangru Tang , Anni Zou , Zhuosheng Zhang , Ziming Li , Yilun Zhao , Xingyao Zhang , Arman Cohan , Mark Gerstein

As language models have a greater impact on society, it is important to ensure they are aligned to a diverse range of perspectives and are able to reflect nuance in human values. However, the most popular training paradigms for modern…

Computation and Language · Computer Science 2025-10-21 Chu Fei Luo , Samuel Dahan , Xiaodan Zhu

The impressive performance of generalist large language models (LLMs) such as GPT and Claude in healthcare raises a critical question: will domain-specific medical specialist models become obsolete? We argue that the future of medical…

Artificial Intelligence · Computer Science 2026-05-29 Yanan Wang , Shuaicong Hu , Jian Liu , Guohui Zhou , Aiguo Wang , Cuiwei Yang

Large Language Models (LLMs) alignment methods have been credited with the commercial success of products like ChatGPT, given their role in steering LLMs towards user-friendly outputs. However, current alignment techniques predominantly…

Computers and Society · Computer Science 2025-09-15 Oriane Peter , Kate Devlin
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