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While large language models show promise in medical applications, achieving expert-level clinical reasoning remains challenging due to the need for both accurate answers and transparent reasoning processes. To address this challenge, we…

Machine Learning · Computer Science 2025-09-22 Chi Liu , Derek Li , Yan Shu , Robin Chen , Derek Duan , Teng Fang , Bryan Dai

Developing the logic necessary to solve mathematical problems or write mathematical proofs is one of the more difficult objectives for large language models (LLMS). Currently, the most popular methods in literature consists of fine-tuning…

Machine Learning · Computer Science 2025-02-11 Tianbo Yang , Mingqi Yan , Hongyi Zhao , Tianshuo Yang

Large language models (LLMs) typically utilize the top-k contexts from a retriever in retrieval-augmented generation (RAG). In this work, we propose a novel instruction fine-tuning framework RankRAG, which instruction-tunes a single LLM for…

Computation and Language · Computer Science 2024-07-03 Yue Yu , Wei Ping , Zihan Liu , Boxin Wang , Jiaxuan You , Chao Zhang , Mohammad Shoeybi , Bryan Catanzaro

Language agents powered by large language models (LLMs) have demonstrated remarkable capabilities in understanding, reasoning, and executing complex tasks. However, developing robust agents presents significant challenges: substantial…

Computation and Language · Computer Science 2025-06-02 Qianqian Zhang , Jiajia Liao , Heting Ying , Yibo Ma , Haozhan Shen , Jingcheng Li , Peng Liu , Lu Zhang , Chunxin Fang , Kyusong Lee , Ruochen Xu , Tiancheng Zhao

Large language models (LLMs) have saturated standard medical benchmarks that test factual recall, yet their ability to perform higher-order reasoning, such as synthesizing evidence from multiple sources, remains critically under-explored.…

Computation and Language · Computer Science 2026-05-12 Huy Hoang Ha , Benoit Favre , Francois Portet

Large Language Models (LLMs) are being adopted at an unprecedented rate, yet still face challenges in knowledge-intensive domains like biomedicine. Solutions such as pre-training and domain-specific fine-tuning add substantial computational…

Effective reasoning is crucial to solving complex mathematical problems. Recent large language models (LLMs) have boosted performance by scaling test-time computation through long chain-of-thought reasoning. However, transformer-based…

Machine Learning · Computer Science 2025-09-10 Junxiong Wang , Wen-Ding Li , Daniele Paliotta , Daniel Ritter , Alexander M. Rush , Tri Dao

Current comparisons of large reasoning models (LRMs) focus on macro-level statistics such as task accuracy or reasoning length. Whether different LRMs reason differently remains an open question. To address this gap, we introduce the…

Computation and Language · Computer Science 2025-09-30 Yida Chen , Yuning Mao , Xianjun Yang , Suyu Ge , Shengjie Bi , Lijuan Liu , Saghar Hosseini , Liang Tan , Yixin Nie , Shaoliang Nie

Gene set analysis, a popular approach for analyzing high-throughput gene expression data, aims to identify sets of related genes that show significantly enriched or depleted expression patterns between different conditions. In the last…

Retrieval-augmented generation (RAG) enhances the question-answering (QA) abilities of large language models (LLMs) by integrating external knowledge. However, adapting general-purpose RAG systems to specialized fields such as science and…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hui Liu , Sreyashi Nag , Zhenwei Dai , Yaochen Xie , Xianfeng Tang , Chen Luo , Yang Li , Joyce C. Ho , Carl Yang , Qi He

Integrating large language models (LLMs) like DeepSeek R1 into healthcare requires rigorous evaluation of their reasoning alignment with clinical expertise. This study assesses DeepSeek R1's medical reasoning against expert patterns using…

Computation and Language · Computer Science 2025-04-02 Birger Moell , Fredrik Sand Aronsson , Sanian Akbar

Reinforcement learning (RL) has become a powerful approach for improving the reasoning capabilities of large language models (LLMs), as evidenced by recent successes such as OpenAI's o1 and Deepseek-R1. However, applying RL at scale remains…

Machine Learning · Computer Science 2025-06-23 Siru Ouyang , Xinyu Zhu , Zilin Xiao , Minhao Jiang , Yu Meng , Jiawei Han

Large Language Models (LLMs) have been integrated into recommender systems to enhance user behavior comprehension. The Retrieval Augmented Generation (RAG) technique is further incorporated into these systems to retrieve more relevant items…

Information Retrieval · Computer Science 2025-03-27 Sichun Luo , Jian Xu , Xiaojie Zhang , Linrong Wang , Sicong Liu , Hanxu Hou , Linqi Song

This technical report details a novel approach to combining reasoning and retrieval augmented generation (RAG) within a single, lean language model architecture. While existing RAG systems typically rely on large-scale models and external…

Retrieval-Augmented Generation (RAG) enables large language models (LLMs) to access external knowledge sources, but the effectiveness of RAG relies on the coordination between the retriever and the generator. Since these components are…

Computation and Language · Computer Science 2025-09-24 Junlin Wang , Zehao Wu , Shaowei Lu , Yanlan Li , Xinghao Huang

We propose Rec-R1, a general reinforcement learning framework that bridges large language models (LLMs) with recommendation systems through closed-loop optimization. Unlike prompting and supervised fine-tuning (SFT), Rec-R1 directly…

Information Retrieval · Computer Science 2026-01-30 Jiacheng Lin , Tian Wang , Kun Qian

Visual generation models have made remarkable progress in creating realistic images from text prompts, yet struggle with complex prompts that specify multiple objects with precise spatial relationships and attributes. Effective handling of…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Chengqi Duan , Rongyao Fang , Yuqing Wang , Kun Wang , Linjiang Huang , Xingyu Zeng , Hongsheng Li , Xihui Liu

Recent advancements in machine learning have significantly improved the identification of disease-associated genes from gene expression datasets. However, these processes often require extensive expertise and manual effort, limiting their…

Machine Learning · Computer Science 2025-04-09 Haoyang Liu , Shuyu Chen , Ye Zhang , Haohan Wang

We present REARANK, a large language model (LLM)-based listwise reasoning reranking agent. REARANK explicitly reasons before reranking, significantly improving both performance and interpretability. Leveraging reinforcement learning and…

Information Retrieval · Computer Science 2025-05-27 Le Zhang , Bo Wang , Xipeng Qiu , Siva Reddy , Aishwarya Agrawal

Retrieval-Augmented Generation (RAG) lifts the factuality of Large Language Models (LLMs) by injecting external knowledge, yet it falls short on problems that demand multi-step inference; conversely, purely reasoning-oriented approaches…

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