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Artificial intelligence (AI) is increasingly being explored as a tool to support pharmacometric modeling, particularly in addressing the coding challenges associated with NONMEM. In this study, we evaluated the ability of seven AI agents to…
For randomized trials that use text as an outcome, traditional approaches for assessing treatment impact require that each document first be manually coded for constructs of interest by trained human raters. This process, the current…
Systematic reviews are fundamental to evidence-based medicine. Creating one is time-consuming and labour-intensive, mainly due to the need to screen, or assess, many studies for inclusion in the review. Several tools have been developed to…
A decade of rapid advances in artificial intelligence (AI) has opened new opportunities for clinical decision support systems (CDSS), with large language models (LLMs) demonstrating strong reasoning abilities on timely medical tasks.…
Large Language Models (LLMs) often generate substantively relevant content but fail to adhere to formal constraints, leading to outputs that are conceptually correct but procedurally flawed. Traditional prompt refinement approaches focus on…
Evaluating large language models (LLMs) is fundamental, particularly in the context of practical applications. Conventional evaluation methods, typically designed primarily for LLM development, yield numerical scores that ignore the user…
Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…
Systematic reviews are time-consuming endeavors. Historically speaking, knowledgeable humans have had to screen and extract data from studies before it can be analyzed. However, large language models (LLMs) hold promise to greatly…
Large language model (LLM) based coding agents increasingly act as autonomous contributors that generate and merge pull requests, yet their real-world effects on software projects are unclear-especially compared with widely adopted…
Large language models (LLMs) are gaining increasing interests to improve clinical efficiency for medical diagnosis, owing to their unprecedented performance in modelling natural language. Ensuring the safe and reliable clinical…
We qualitatively compared literature reviews produced with varying degrees of AI assistance. The same LLM, given the same corpus of 280 papers but different selections, produced dramatically different reviews, from mainstream and…
The automation of scientific research through large language models (LLMs) presents significant opportunities but faces critical challenges in knowledge synthesis and quality assurance. We introduce Feedback-Refined Agent Methodology…
Evaluating factual accuracy in Large Language Model (LLM)-generated clinical text is a critical barrier to adoption, as expert review is unscalable for the continuous quality assurance these systems require. We address this challenge with…
As human-AI collaboration becomes increasingly prevalent in educational contexts, understanding and measuring the extent and nature of such interactions pose significant challenges. This research investigates the use of authorship…
Autonomous research systems capable of generating complete scientific manuscripts have advanced rapidly, yet robust and realistic evaluation frameworks have failed to keep pace. To bridge this gap, we introduce MLReplicate, an end-to-end…
8 years after the visual question answering (VQA) task was proposed, accuracy remains the primary metric for automatic evaluation. VQA Accuracy has been effective so far in the IID evaluation setting. However, our community is undergoing a…
Pharmaceutical process design and development for generic, innovative, or personalized drugs have always been a time-consuming, costly, rigorous process, that involves multi-stage evaluation for better quality control and assurance. Large…
Large Language Models (LLMs) are now capable of generating text that closely resembles human writing, making them powerful tools for content creation, but this growing ability has also made it harder to tell whether a piece of text was…
Creativity has long been considered one of the most difficult aspect of human intelligence for AI to mimic. However, the rise of Large Language Models (LLMs), like ChatGPT, has raised questions about whether AI can match or even surpass…
The performance of large language models (LLMs) depends on how they are prompted, with choices spanning both the high-level prompting pattern (e.g., Zero-Shot, CoT, ReAct, ReWOO) and the specific prompt content (instructions and few-shot…