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Antibiotic resistance presents a growing global health crisis, demanding new therapeutic strategies that target novel bacterial mechanisms. Recent advances in protein structure prediction and machine learning-driven molecule generation…

Biomolecules · Quantitative Biology 2025-05-22 Maximilian G. Schuh , Joshua Hesse , Stephan A. Sieber

Antibody design is an essential yet challenging task in various domains like therapeutics and biology. There are two major defects in current learning-based methods: 1) tackling only a certain subtask of the whole antibody design pipeline,…

Biomolecules · Quantitative Biology 2023-05-31 Xiangzhe Kong , Wenbing Huang , Yang Liu

We propose LAGO - Language Similarity-Aware Graph Optimization - a novel approach for few-shot cross-lingual embedding inversion attacks, addressing critical privacy vulnerabilities in multilingual NLP systems. Unlike prior work in…

Computation and Language · Computer Science 2025-05-23 Wenrui Yu , Yiyi Chen , Johannes Bjerva , Sokol Kosta , Qiongxiu Li

Recently, large-scale visual language pre-trained (VLP) models have demonstrated impressive performance across various downstream tasks. Motivated by these advancements, pioneering efforts have emerged in multi-label image recognition with…

Computer Vision and Pattern Recognition · Computer Science 2024-08-30 Leilei Ma , Hongxing Xie , Lei Wang , Yanping Fu , Dengdi Sun , Haifeng Zhao

In recent years, sign language processing (SLP) has gained importance in the general field of Natural Language Processing. However, compared to research on spoken languages, SLP research is hindered by complex ad-hoc code, inadvertently…

Computation and Language · Computer Science 2025-09-15 Gerard Sant , Zifan Jiang , Carlos Escolano , Amit Moryossef , Mathias Müller , Rico Sennrich , Sarah Ebling

In-context learning (ICL) has emerged as an effective solution for few-shot learning with large language models (LLMs). However, how LLMs leverage demonstrations to specify a task and learn a corresponding computational function through ICL…

Computation and Language · Computer Science 2025-11-17 Yu Bai , Heyan Huang , Cesare Spinoso-Di Piano , Marc-Antoine Rondeau , Sanxing Chen , Yang Gao , Jackie Chi Kit Cheung

We present a three-stage framework for training deep learning models specializing in antibody sequence-structure co-design. We first pre-train a language model using millions of antibody sequence data. Then, we employ the learned…

Machine Learning · Computer Science 2025-10-24 Yibo Wen , Chenwei Xu , Jerry Yao-Chieh Hu , Kaize Ding , Han Liu

Text attribute person search aims to find specific pedestrians through given textual attributes, which is very meaningful in the scene of searching for designated pedestrians through witness descriptions. The key challenge is the…

Computer Vision and Pattern Recognition · Computer Science 2024-06-07 Xin Wang , Fangfang Liu , Zheng Li , Caili Guo

Existing learning models often exhibit poor generalization when deployed across diverse scenarios. It is primarily due to that the underlying reference frame of the data varies with the deployment environment and settings. However, despite…

Machine Learning · Computer Science 2025-07-02 Zirui Chen , Zhaoyang Zhang , Ziqing Xing , Ridong Li , Zhaohui Yang , Richeng Jin , Chongwen Huang , Yuzhi Yang , Mérouane Debbah

Loop closure detection, the task of identifying locations revisited by a robot in a sequence of odometry and perceptual observations, is typically formulated as a combination of two subtasks: (1) bag-of-words image retrieval and (2)…

Computer Vision and Pattern Recognition · Computer Science 2015-09-28 Kanji Tanaka

Visually similar characters, or homoglyphs, can be used to perform social engineering attacks or to evade spam and plagiarism detectors. It is thus important to understand the capabilities of an attacker to identify homoglyphs --…

Cryptography and Security · Computer Science 2020-12-23 Perry Deng , Cooper Linsky , Matthew Wright

The International Classification of Diseases (ICD) is an authoritative medical classification system of different diseases and conditions for clinical and management purposes. ICD indexing assigns a subset of ICD codes to a medical record.…

Computation and Language · Computer Science 2024-05-30 Xindi Wang , Robert E. Mercer , Frank Rudzicz

Visual In-Context Learning (ICL) has emerged as a promising research area due to its capability to accomplish various tasks with limited example pairs through analogical reasoning. However, training-based visual ICL has limitations in its…

Computer Vision and Pattern Recognition · Computer Science 2024-05-17 Zheng Gu , Shiyuan Yang , Jing Liao , Jing Huo , Yang Gao

Reliable evaluation benchmarks designed for replicability and comprehensiveness have driven progress in machine learning. Due to the lack of a multilingual benchmark, however, vision-and-language research has mostly focused on English…

Computation and Language · Computer Science 2022-07-19 Emanuele Bugliarello , Fangyu Liu , Jonas Pfeiffer , Siva Reddy , Desmond Elliott , Edoardo Maria Ponti , Ivan Vulić

Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating…

Computational Engineering, Finance, and Science · Computer Science 2020-07-01 Xinmeng Li , James A. Van Deventer , Soha Hassoun

Widespread LLM adoption has introduced characteristic repetitive phraseology, termed "slop," which degrades output quality and makes AI-generated text immediately recognizable. We present Antislop, a comprehensive framework providing tools…

Machine Learning · Computer Science 2025-10-23 Samuel Paech , Allen Roush , Judah Goldfeder , Ravid Shwartz-Ziv

Large language models have recently demonstrated advanced capabilities in solving IMO and Putnam problems; yet their role in research mathematics has remained fairly limited. The key difficulty is verification: suggested proofs may look…

Artificial Intelligence · Computer Science 2025-10-17 Ayush Khaitan , Vijay Ganesh

Cross-lingual transfer learning is an important property of multilingual large language models (LLMs). But how do LLMs represent relationships between languages? Every language model has an input layer that maps tokens to vectors. This…

Computation and Language · Computer Science 2023-12-19 Andrea W Wen-Yi , David Mimno

Predicting interactions between biomolecules, such as protein-protein complexes, remains a challenging problem. Despite the many advancements done so far, the performances of docking protocols are deeply dependent on their capability of…

Biomolecules · Quantitative Biology 2025-08-19 Greta Grassmann , Lorenzo Di Rienzo , Giancarlo Ruocco , Mattia Miotto , Edoardo Milanetti

Identifying drug-target interactions is essential for developing effective therapeutics. Binding affinity quantifies these interactions, and traditional approaches rely on computationally intensive 3D structural data. In contrast, language…

Quantitative Methods · Quantitative Biology 2024-11-08 Radheesh Sharma Meda , Amir Barati Farimani