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We develop ProtComposer to generate protein structures conditioned on spatial protein layouts that are specified via a set of 3D ellipsoids capturing substructure shapes and semantics. At inference time, we condition on ellipsoids that are…

Biomolecules · Quantitative Biology 2025-03-10 Hannes Stark , Bowen Jing , Tomas Geffner , Jason Yim , Tommi Jaakkola , Arash Vahdat , Karsten Kreis

Acquiring annotated data at scale with rare diseases or conditions remains a challenge. It would be extremely useful to have a method that controllably synthesizes images that can correct such underrepresentation. Assuming a proper latent…

Image and Video Processing · Electrical Eng. & Systems 2021-07-06 Spyridon Thermos , Xiao Liu , Alison O'Neil , Sotirios A. Tsaftaris

Image composition and generation are processes where the artists need control over various parts of the generated images. However, the current state-of-the-art generation models, like Stable Diffusion, cannot handle fine-grained part-level…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Harsh Rangwani , Aishwarya Agarwal , Kuldeep Kulkarni , R. Venkatesh Babu , Srikrishna Karanam

Alterations in the geometry and function of the heart define well-established causes of cardiovascular disease. However, current approaches to the diagnosis of cardiovascular diseases often rely on subjective human assessment as well as…

Computer Vision and Pattern Recognition · Computer Science 2018-07-19 Carlo Biffi , Ozan Oktay , Giacomo Tarroni , Wenjia Bai , Antonio De Marvao , Georgia Doumou , Martin Rajchl , Reem Bedair , Sanjay Prasad , Stuart Cook , Declan O'Regan , Daniel Rueckert

We present Anatomica: an inference-time framework for generating multi-class anatomical voxel maps with localized geo-topological control. During generation, we use cuboidal control domains of varying dimensionality, location, and shape to…

Machine Learning · Computer Science 2025-11-26 Karim Kadry , Abdallah Abdelwahed , Shoaib Goraya , Ajay Manicka , Naravich Chutisilp , Farhad Nezami , Elazer Edelman

Recent large-scale generative models learned on big data are capable of synthesizing incredible images yet suffer from limited controllability. This work offers a new generation paradigm that allows flexible control of the output image,…

Computer Vision and Pattern Recognition · Computer Science 2023-02-23 Lianghua Huang , Di Chen , Yu Liu , Yujun Shen , Deli Zhao , Jingren Zhou

Diffusion models have enabled remarkably high-quality medical image generation, yet it is challenging to enforce anatomical constraints in generated images. To this end, we propose a diffusion model-based method that supports…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Nicholas Konz , Yuwen Chen , Haoyu Dong , Maciej A. Mazurowski

The discovery of small organic compounds for inducing stem cell differentiation is a time- and resource-intensive process. While data science could, in principle, facilitate the discovery of these compounds, novel approaches are required…

Echocardiography video is a primary modality for diagnosing heart diseases, but the limited data poses challenges for both clinical teaching and machine learning training. Recently, video generative models have emerged as a promising…

Image and Video Processing · Electrical Eng. & Systems 2024-08-01 Junxuan Yu , Rusi Chen , Yongsong Zhou , Yanlin Chen , Yaofei Duan , Yuhao Huang , Han Zhou , Tan Tao , Xin Yang , Dong Ni

Accurate 3D cardiac reconstruction from cine magnetic resonance imaging (cMRI) is crucial for improved cardiovascular disease diagnosis and understanding of the heart's motion. However, current cardiac MRI-based reconstruction technology…

Image and Video Processing · Electrical Eng. & Systems 2023-08-21 Xiaoxiao He , Chaowei Tan , Ligong Han , Bo Liu , Leon Axel , Kang Li , Dimitris N. Metaxas

Despite their impressive visual fidelity, existing personalized image generators lack interactive control over spatial composition and scale poorly to multiple humans. To address these limitations, we present LayerComposer, an interactive…

We present PartComposer: a framework for part-level concept learning from single-image examples that enables text-to-image diffusion models to compose novel objects from meaningful components. Existing methods either struggle with…

Graphics · Computer Science 2025-09-16 Junyu Liu , R. Kenny Jones , Daniel Ritchie

Image composition targets at synthesizing a realistic composite image from a pair of foreground and background images. Recently, generative composition methods are built on large pretrained diffusion models to generate composite images,…

Computer Vision and Pattern Recognition · Computer Science 2023-08-22 Bo Zhang , Yuxuan Duan , Jun Lan , Yan Hong , Huijia Zhu , Weiqiang Wang , Li Niu

Latent diffusion models (LDMs) have recently achieved strong performance in 3D medical image synthesis. However, modalities like cine cardiac MRI (CMR), representing a temporally synchronized 3D volume across the cardiac cycle, add an…

Understanding the architecture of the human heart requires analysis of its microstructural organization across scales. With the advent of high-resolution imaging techniques such as synchrotron-based tomography, it has become possible to…

Computational Engineering, Finance, and Science · Computer Science 2025-08-12 Joseph Brunet , Lisa Chestnutt , Matthieu Chourrout , Hector Dejea , Vaishnavi Sabarigirivasan , Peter D. Lee , Andrew C. Cook

The rhythmic pumping motion of the heart stands as a cornerstone in life, as it circulates blood to the entire human body through a series of carefully timed contractions of the individual chambers. Changes in the size, shape and movement…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Kristine Sørensen , Paula Diez , Jan Margeta , Yasmin El Youssef , Michael Pham , Jonas Jalili Pedersen , Tobias Kühl , Ole de Backer , Klaus Kofoed , Oscar Camara , Rasmus Paulsen

Accurate segmentation of cardiac structures in cardiovascular magnetic resonance (CMR) images is essential for reliable diagnosis and treatment of cardiovascular diseases. However, manual segmentation remains time-consuming and suffers from…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Ujjwal Jain

Creating and editing high-quality 3D content remains a central challenge in computer graphics. We address this challenge by introducing CompoSE, a novel method for Compositional Synthesis and Editing of 3D shapes via part-aware control. Our…

Graphics · Computer Science 2026-05-20 Habib Slim , Shariq Farooq Bhat , Mohamed Elhoseiny , Yifan Wang , Mike Roberts

Anatomy shape modeling is a fundamental problem in medical data analysis. However, the geometric complexity and topological variability of anatomical structures pose significant challenges to accurate anatomical shape generation. In this…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Guoqing Zhang , Jingyun Yang , Siqi Chen , Anping Zhang , Yang Li

This work introduces TrajDiffuser, a compositional diffusion-based flexible and concurrent trajectory generator for 6 degrees of freedom powered descent guidance. TrajDiffuser is a statistical model that learns the multi-modal distributions…

Robotics · Computer Science 2024-10-08 Julia Briden , Yilun Du , Enrico M. Zucchelli , Richard Linares
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