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We propose a doubly robust approach to characterizing treatment effect heterogeneity in observational studies. We develop a frequentist inferential procedure that utilizes posterior distributions for both the propensity score and outcome…

Methodology · Statistics 2022-07-21 Heejun Shin , Joseph Antonelli

Integrating multimodal Electronic Health Records (EHR) data, such as numerical time series and free-text clinical reports, has great potential in predicting clinical outcomes. However, prior work has primarily focused on capturing temporal…

Machine Learning · Computer Science 2025-11-10 Fuying Wang , Feng Wu , Yihan Tang , Lequan Yu

Machine learning methods, particularly the double machine learning (DML) estimator (Chernozhukov et al., 2018), are increasingly popular for the estimation of the average treatment effect (ATE). However, datasets often exhibit unbalanced…

Econometrics · Economics 2024-06-12 Daniele Ballinari

In this article, we propose novel structural nested models to estimate causal effects of continuous treatments based on mobile health data. To find the treatment regime that optimizes the expected short-term outcomes for patients, we define…

Methodology · Statistics 2020-07-24 Liangyu Zhu , Wenbin Lu , Rui Song

This study proposes a Transformer-based longitudinal modeling method to address challenges in clinical risk classification with heterogeneous Electronic Health Record (EHR) data, including irregular temporal patterns, large modality…

Machine Learning · Computer Science 2025-11-07 Anzhuo Xie , Wei-Chen Chang

The increased adoption of Electronic Health Records(EHRs) has brought changes to the way the patient care is carried out. The rich heterogeneous and temporal data space stored in EHRs can be leveraged by machine learning models to capture…

Machine Learning · Computer Science 2019-04-11 Maria Bampa

Medical researchers are coming to appreciate that many diseases are in fact complex, heterogeneous syndromes composed of subpopulations that express different variants of a related complication. Time series data extracted from individual…

Machine Learning · Statistics 2016-06-30 Peter Schulam , Raman Arora

We suggest a low cost, non invasive healthcare system that measures haemoglobin levels in patients and can be used as a preliminary diagnostic test for anaemia. A combination of image processing, machine learning and deep learning…

Machine Learning · Computer Science 2020-12-01 Sarah , S. Sidhartha Narayan , Irfaan Arif , Hrithwik Shalu , Juned Kadiwala

A widely-used model for determining the long-term health impacts of public health interventions, often called a "multistate lifetable", requires estimates of incidence, case fatality, and sometimes also remission rates, for multiple…

Applications · Statistics 2023-03-23 Christopher Jackson , Belen Zapata-Diomedi , James Woodcock

Assessing treatment effect heterogeneity (TEH) in clinical trials is crucial, as it provides insights into the variability of treatment responses among patients, influencing important decisions related to drug development. Furthermore, it…

Applications · Statistics 2026-02-06 Konstantinos Sechidis , Cong Zhang , Sophie Sun , Yao Chen , Asher Spector , Björn Bornkamp

Non-negative two-part outcomes are defined as outcomes with a density function that have a zero point mass but are otherwise positive. Examples, such as healthcare expenditure and hospital length of stay, are common in healthcare…

Estimating heterogeneous treatment effects in domains such as healthcare or social science often involves sensitive data where protecting privacy is important. We introduce a general meta-algorithm for estimating conditional average…

Machine Learning · Statistics 2022-02-23 Fengshi Niu , Harsha Nori , Brian Quistorff , Rich Caruana , Donald Ngwe , Aadharsh Kannan

Speech is a noninvasive digital phenotype that can offer valuable insights into mental health conditions, but it is often treated as a single modality. In contrast, we propose the treatment of patient speech data as a trimodal multimedia…

Computation and Language · Computer Science 2025-07-24 Mai Ali , Christopher Lucasius , Tanmay P. Patel , Madison Aitken , Jacob Vorstman , Peter Szatmari , Marco Battaglia , Deepa Kundur

People are living longer than ever before, and with this arises new complications and challenges for humanity. Among the most pressing of these challenges is of understanding the role of aging in the development of dementia. This paper is…

Methodology · Statistics 2018-08-07 Jonathan P Williams , Curtis B Storlie , Terry M Therneau , Clifford R Jack , Jan Hannig

Identifying heterogeneous treatment effects (HTEs) in randomized controlled trials is an important step toward understanding and acting on trial results. However, HTEs are often small and difficult to identify, and HTE modeling methods…

Methodology · Statistics 2020-11-24 Erin Craig , Donald A Redelmeier , Robert J Tibshirani

This Element offers a practical guide to estimating conditional marginal effects-how treatment effects vary with a moderating variable-using modern statistical methods. Commonly used approaches, such as linear interaction models, often…

Methodology · Statistics 2026-05-21 Jiehan Liu , Ziyi Liu , Yiqing Xu

Due to the recent advancements in wearables and sensing technology, health scientists are increasingly developing mobile health (mHealth) interventions. In mHealth interventions, mobile devices are used to deliver treatment to individuals…

Machine Learning · Computer Science 2020-07-24 Peng Liao , Predrag Klasnja , Susan Murphy

With the rapid development of wearable device technologies, accelerometers can record minute-by-minute physical activity for consecutive days, which provides important insight into a dynamic association between the intensity of physical…

Methodology · Statistics 2024-09-06 Cheng Cao , Jiguo Cao , Hao Pan , Yunting Zhang , Fan Jiang , Xinyue Li

Due to the popularity of smartphones and wearable devices nowadays, mobile health (mHealth) technologies are promising to bring positive and wide impacts on people's health. State-of-the-art decision-making methods for mHealth rely on some…

Machine Learning · Computer Science 2017-08-15 Feiyun Zhu , Jun Guo , Zheng Xu , Peng Liao , Junzhou Huang

Optimizing credit limits, interest rates, and loan terms is crucial for managing borrower risk and lifetime value (LTV) in personal loan platform. However, counterfactual estimation of these continuous, multi-dimensional treatments faces…

Machine Learning · Computer Science 2025-08-12 Kexin Zhao , Bo Wang , Cuiying Zhao , Tongyao Wan