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This study explores the implementation of the Quantum Approximate Optimisation Algorithm (QAOA) in its analog form using a neutral atom quantum processing unit to solve the Maximum Independent Set problem. The analog QAOA leverages the…

Quantum Physics · Physics 2025-11-26 Simone Tibaldi , Lucas Leclerc , Davide Vodola , Edoardo Tignone , Elisa Ercolessi

The aircraft loading optimization problem is a computationally hard problem with the best known classical algorithm scaling exponentially with the number of objects. We propose a quantum approach based on a multi-angle variant of the QAOA…

The Quantum Alternating Operator Ansatz (QAOA) is a promising gate-model meta-heuristic for combinatorial optimization. Applying the algorithm to problems with constraints presents an implementation challenge for near-term quantum…

Quantum Physics · Physics 2020-05-25 Zhihui Wang , Nicholas C. Rubin , Jason M. Dominy , Eleanor G. Rieffel

The prospect of quantum solutions for complicated optimization problems is contingent on mapping the original problem onto a tractable quantum energy landscape, e.g. an Ising-type Hamiltonian. Subsequently, techniques like adiabatic…

Quantum Physics · Physics 2025-10-17 Sebastian Egginger , Kristina Kirova , Sonja Bruckner , Stefan Hillmich , Richard Kueng

When tackling binary optimization problems using quantum algorithms, the conventional Ising representation and Quantum Approximate Optimization Algorithm (QAOA) encounter difficulties in efficiently handling errors for large-scale problems…

Quantum Physics · Physics 2023-05-16 Ke Wan , Yiwen Liu

An enhanced framework of quantum approximate optimization algorithm (QAOA) is introduced and the parameter setting strategies are analyzed. The enhanced QAOA is as effective as the QAOA but exhibits greater computing power and flexibility,…

Quantum Physics · Physics 2020-12-18 Mingyou Wu , Zhihao Liu , Hanwu Chen

We present a theoretical framework for the analysis of amplitude transfer in Quantum Variational Algorithms (QVAs) for combinatorial optimisation with mixing unitaries defined by vertex-transitive graphs, based on their continuous-time…

Quantum Physics · Physics 2024-06-24 Edric Matwiejew , Jingbo B. Wang

Running quantum circuits on quantum computers does not always generate "clean" results, unlike on a simulator, as noise plays a significant role in any quantum device. To explore this, we experimented with the Quantum Approximate…

Quantum Physics · Physics 2025-10-09 Abyan Khabir Irfan , Chansu Yu

The Quantum Approximate Optimization Algorithm (QAOA) follows a single, fixed evolution path, overlooking the potential computational advantage of coherently superposing multiple trajectories. Here we overcome this limitation with a hybrid…

Quantum Physics · Physics 2026-04-29 Tianen Chen , Yun Shang

Constrained combinatorial optimization with strict linear constraints underpins applications in drug discovery, power grids, logistics, and finance, yet remains computationally demanding for classical algorithms, especially at large scales.…

Quantum Physics · Physics 2026-04-07 Yajie Hao , Qiming Ding , Xiao Yuan , Xiaoting Wang

The Quantum Approximate Optimization Algorithm (QAOA) and its derived variants are widely in use for approximating combinatorial optimization problem instances on gate-based Noisy Intermediate Scale Quantum (NISQ) computers. Commonly,…

Quantum Physics · Physics 2025-07-11 Simon Garhofer , Oliver Bringmann

Quantum algorithms can be used to perform unsupervised machine learning tasks like data clustering by mapping the distance between data points to a graph optimization problem (i.e. MAXCUT) and finding optimal solution through energy…

Quantum Physics · Physics 2022-02-08 Daniel Beaulieu , Anh Pham

In the pursuit of achieving near-term quantum advantage for combinatorial optimization problems, the Quantum Approximate Optimization Algorithm (QAOA) and the Variational Quantum Eigensolver (VQE) are the primary methods of interest, but…

Quantum Physics · Physics 2025-03-06 Adelina Bärligea , Benedikt Poggel , Jeanette Miriam Lorenz

Quadratic unconstrained binary optimization (QUBO) tasks are very important in chemistry, finance, job scheduling, and so on, which can be represented using graph structures, with the variables as nodes and the interaction between them as…

Quantum Physics · Physics 2024-04-10 Yuhan Huang , Ferris Prima Nugraha , Siyuan Jin , Yichi Zhang , Bei Zeng , Qiming Shao

Quantum computers show potential for achieving computational advantage over classical computers, with many candidate applications in combinatorial optimisation. We present an application level benchmarking framework for near-term quantum…

Molecular docking is a critical process for drug discovery and challenging due to the complexity and size of biomolecular systems, where the optimal binding configuration of a drug to a target protein is determined. Hybrid classical-quantum…

Emerging Technologies · Computer Science 2025-03-07 Christos Papalitsas , Yanfei Guan , Shreyas Waghe , Athanasios Liakos , Ioannis Balatsos , Vassilios Pantazopoulos

A frequent starting point of quantum computation platforms are two-state quantum systems, i.e., qubits. However, in the context of integer optimization problems, relevant to scheduling optimization and operations research, it is often more…

Solving combinatorial optimization problems on near-term quantum devices has gained a lot of attraction in recent years. Currently, most works have focused on single-objective problems, whereas many real-world applications need to consider…

Quantum Physics · Physics 2025-06-06 Linus Ekstrom , Hao Wang , Sebastian Schmitt

Quantum computing is an emerging field on the multidisciplinary interface between physics, engineering, and computer science with the potential to make a large impact on computational intelligence (CI). The aim of this paper is to introduce…

The task of Multiple Sequence Alignment (MSA) is a constrained combinatorial optimization problem that is generally considered a complex computational problem. In this paper, we first present a binary encoding of MSA and devise a…

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