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Deploying motile nanosized particles, also known as ``nanobots'', in the human body promises to improve selectivity in drug delivery and reduce side effects. We consider a swarm of nanobots locating a single cancerous region and treating it…

Multiagent Systems · Computer Science 2025-07-17 Noble Harasha , Cristina Gava , Nancy Lynch , Claudia Contini , Frederik Mallmann-Trenn

Although nanorobots have been used as clinical prescriptions for work such as gastroscopy, and even photoacoustic tomography technology has been proposed to control nanorobots to deliver drugs at designated delivery points in real time, and…

Robotics · Computer Science 2022-04-18 Xinyu Zhou

Despite all the advances achieved in the field of tumor-biology research, in most cases conventional therapies including chemotherapy are still the leading choices. The main disadvantage of these treatments, in addition to the low…

Tissues and Organs · Quantitative Biology 2024-01-25 Paola Sanchez-Moreno , Juan Luis Ortega-Vinuesa , Jose Manuel Peula-Garcia , Juan Antonio Marchal , Houria Boulaiz

This paper considers the scenario of a targeted drug delivery system, which consists of deploying a number of biological nanomachines close to a biological target (e.g. a tumor), able to deliver drug molecules in the diseased area. Suitably…

Emerging Technologies · Computer Science 2018-08-14 Mauro Femminella , Gianluca Reali , Athanasios V. Vasilakos

Evolutionary algorithms have long been used for optimization problems where the appropriate size of solutions is unclear a priori. The applicability of this methodology is here investigated on the problem of designing a nano-particle (NP)…

Neural and Evolutionary Computing · Computer Science 2020-11-11 Michail-Antisthenis Tsompanas , Larry Bull , Andrew Adamatzky , Igor Balaz

We investigate algorithmic approaches for targeted drug delivery in a complex, maze-like environment, such as a vascular system. The basic scenario is given by a large swarm of micro-scale particles (''agents'') and a particular target…

Computational Geometry · Computer Science 2024-08-20 Aaron T. Becker , Sándor P. Fekete , Li Huang , Phillip Keldenich , Linda Kleist , Dominik Krupke , Christian Rieck , Arne Schmidt

We present the EVONANO platform for the evolution of nanomedicines with application to anti-cancer treatments. EVONANO includes a simulator to grow tumours, extract representative scenarios, and then simulate nanoparticle transport through…

Neural and Evolutionary Computing · Computer Science 2021-02-02 Namid Stillman , Igor Balaz , Antisthenis Tsompanas , Marina Kovacevic , Sepinoud Azimi , Sebastien Lafond , Andrew Adamatzky , Sabine Hauert

Chemotherapy treatment for cancer is a complex optimisation problem with a large number of interacting variables and constraints. A number of different probabilistic algorithms have been applied to it with varying success. In this paper we…

Artificial Intelligence · Computer Science 2022-05-18 Alexander Brownlee , Martin Pelikan , John McCall , Andrei Petrovski

A network of nanomachines (NMs) can be used to build a target detection system for a variety of promising applications. They have the potential to detect toxic chemicals, infectious bacteria, and biomarkers of dangerous diseases such as…

Information Theory · Computer Science 2024-01-10 Nithin V. Sabu , Abhishek K. Gupta

We propose a new framework of computing-inspired multifocal cancer detection procedure (MCDP). Under the rubric of MCDP, the tumor foci to be detected are regarded as solutions of the objective function, the tissue region around the cancer…

Tissues and Organs · Quantitative Biology 2019-01-01 Shaolong Shi , Yifan Chen , Xin Yao

This work presents a performance analysis for diffusive molecular communication with mobile transmit and receive nanomachines. To begin with, the optimal test is obtained for symbol detection at the receiver nanomachine. Subsequently,…

Information Theory · Computer Science 2017-10-04 Neeraj Varshney , Aditya K. Jagannatham , Pramod K. Varshney

Colorectal cancer (CRC) continues to be a significant global health burden, prompting the need for more effective and targeted therapeutic strategies. Nanoparticle-based drug delivery systems have emerged as a promising approach to address…

Other Quantitative Biology · Quantitative Biology 2024-09-10 Mahadi Hasan , Camryn Grace Evett , Jack Burton

Early detection of cancer is essential for timely diagnosis and improved patient outcomes. Among emerging technologies, intra-body nanoscale communication offers an innovative solution to identify molecular cues within the human…

Emerging Technologies · Computer Science 2026-03-12 Abdollah Rezagholi , Sergi Abadal , Filip Lemic , Eduard Alarcon , Ethungshan Shitiri

Cancer is one of the most common diseases worldwide, posing a serious threat to human health and leading to the deaths of a large number of people. It was observed during the drug administration in chemotherapy that immune cells, cancer…

Quantitative Methods · Quantitative Biology 2020-08-20 SeyedMehdi Abtahi , Mojtaba Sharifi

The question of how "smart" active agents, like insects, microorganisms, or future colloidal robots need to steer to optimally reach or discover a target, such as an odor source, food, or a cancer cell in a complex environment has recently…

Soft Condensed Matter · Physics 2023-04-05 Mahdi Nasiri , Hartmut Löwen , Benno Liebchen

The study explores Artificial Intelligence (AI) powered modeling to predict the evolution of cancer tumor cells in mice under different forms of treatment. The AI models are analyzed against varying ambient and systemic parameters, e.g.…

Biological Physics · Physics 2024-08-12 Amit K Chattopadhyay , Aimee Pascaline N Unkundiye , Gillian Pearce , Steven Russell

In this work, we propose a Machine Learning model that generates an adjustable 3D dose distribution for external beam radiation therapy for head-and-neck cancer treatments. In contrast to existing Machine Learning methods that provide a…

Deep learning (DL) has successfully automated dose distribution prediction in radiotherapy planning, enhancing both efficiency and quality. However, existing methods suffer from the over-smoothing problem for their commonly used L1 or L2…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Zhenghao Feng , Lu Wen , Jianghong Xiao , Yuanyuan Xu , Xi Wu , Jiliu Zhou , Xingchen Peng , Yan Wang

Medicine has taken a big jump in its advancement in the past few years. With the introduction of technology and the synthesis of personalized medicines, doctors have been successful in treating even the deadliest of the diseases. Though…

Medical Physics · Physics 2020-11-10 Puru Malhotra , Nimesh Shahdadpuri

Accurately predicting drug responses to cancer is an important problem hindering oncologists' efforts to find the most effective drugs to treat cancer, which is a core goal in precision medicine. The scientific community has focused on…

Machine Learning · Computer Science 2016-12-06 Turki Turki , Zhi Wei
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