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Lung cancer remains the leading cause of cancer-related mortality worldwide, with survival strongly dependent on early detection. Standard-dose computed tomography (CT) screening using the Lung Imaging Reporting and Data System (Lung-RADS)…

Lung cancer remains one of the leading causes of cancer-related mortality worldwide. A crucial challenge for early diagnosis is differentiating uncertain cases with similar visual characteristics and closely annotation scores. In clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-03-27 Sadaf Khademi , Mehran Shabanpour , Reza Taleei , Anastasia Oikonomou , Arash Mohammadi

Large language models (LLMs) have emerged as transformative tools in medicine, with strong capabilities in language understanding, reasoning, and structured information extraction. Radiation oncology is particularly well suited for LLM…

Lung cancer is the leading cause of cancer-related mortality worldwide. Lung cancer screening (LCS) using annual low-dose computed tomography (CT) scanning has been proven to significantly reduce lung cancer mortality by detecting cancerous…

Vision-language models (VLMs) have shown strong promise for medical image analysis, but most remain opaque, offering predictions without the transparent, stepwise reasoning clinicians rely on. We present a framework that brings…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Andriy Myronenko , Dong Yang , Baris Turkbey , Mariam Aboian , Sena Azamat , Esra Akcicek , Hongxu Yin , Pavlo Molchanov , Marc Edgar , Yufan He , Pengfei Guo , Yucheng Tang , Daguang Xu

Accurate lung cancer risk prediction remains challenging due to substantial variability across patient populations and clinical settings -- no single model performs best for all cohorts. To address this, we propose a personalized lung…

Machine Learning · Computer Science 2025-08-27 Chongyu Qu , Allen J. Luna , Thomas Z. Li , Junchao Zhu , Junlin Guo , Juming Xiong , Kim L. Sandler , Bennett A. Landman , Yuankai Huo

At the heart of radiological practice is the challenge of integrating complex imaging data with clinical information to produce actionable insights. Nuanced application of language is key for various activities, including managing requests,…

Background: Modern large language models (LLMs) offer powerful reasoning that converts narratives into structured, taxonomy-aligned data, revealing patterns across planning, delivery, and verification. Embedded as agentic tools, LLMs can…

Clinical oncology generates vast, unstructured data that often contain inconsistencies, missing information, and ambiguities, making it difficult to extract reliable insights for data-driven decision-making. General-purpose large language…

Computation and Language · Computer Science 2025-03-12 Morteza Rohanian , Tarun Mehra , Nicola Miglino , Farhad Nooralahzadeh , Michael Krauthammer , Andreas Wicki

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Context. Risk analysis assesses potential risks in specific scenarios. Risk analysis principles are context-less; the same methodology can be applied to a risk connected to health and information technology security. Risk analysis requires…

Computation and Language · Computer Science 2024-09-10 Matteo Esposito , Francesco Palagiano , Valentina Lenarduzzi , Davide Taibi

Background: Structured radiology reports remains underdeveloped due to labor-intensive structuring and narrative-style reporting. Deep learning, particularly large language models (LLMs) like GPT-3.5, offers promise in automating the…

Computation and Language · Computer Science 2024-10-30 Hidetoshi Matsuo , Mizuho Nishio , Takaaki Matsunaga , Koji Fujimoto , Takamichi Murakami

Advances in large language models (LLMs) have encouraged their adoption in the healthcare domain where vital clinical information is often contained in unstructured notes. Cancer staging status is available in clinical reports, but it…

Computation and Language · Computer Science 2024-08-30 Chia-Hsuan Chang , Mary M. Lucas , Yeawon Lee , Christopher C. Yang , Grace Lu-Yao

Large annotated datasets are essential for training robust Computer-Aided Diagnosis (CAD) models for breast cancer detection or risk prediction. However, acquiring such datasets with fine-detailed annotation is both costly and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Shunjie-Fabian Zheng , Hyeonjun Lee , Thijs Kooi , Ali Diba

Radiology reports are often lengthy and unstructured, posing challenges for referring physicians to quickly identify critical imaging findings while increasing the risk of missed information. This retrospective study aimed to enhance…

Computation and Language · Computer Science 2025-06-05 Iryna Hartsock , Cyrillo Araujo , Les Folio , Ghulam Rasool

Accurately communicating the side effects of cancer treatments to cancer survivors is critical, particularly in settings such as informed consent, where clinicians must clearly and comprehensively convey potential treatment toxicities.…

Computation and Language · Computer Science 2026-05-19 Natalie Seah , Danielle S. Bitterman , Daphna Spiegel , Thomas Hartvigsen

Accurate preoperative assessment of lymph node (LN) metastasis in rectal cancer guides treatment decisions, yet conventional MRI evaluation based on morphological criteria shows limited diagnostic performance. While some artificial…

Machine Learning · Computer Science 2025-07-16 Yaoxian Dong , Yifan Gao , Haoyue Li , Yanfen Cui , Xin Gao

Reasoning Language Models (RLMs) have gained traction for their ability to perform complex, multi-step reasoning tasks through mechanisms such as Chain-of-Thought (CoT) prompting or fine-tuned reasoning traces. While these capabilities…

Computation and Language · Computer Science 2025-07-04 Riccardo Cantini , Nicola Gabriele , Alessio Orsino , Domenico Talia

Prognosis prediction is crucial for determining optimal treatment plans for lung cancer patients. Traditionally, such predictions relied on models developed from retrospective patient data. Recently, large language models (LLMs) have gained…

Computation and Language · Computer Science 2024-08-16 Danqing Hu , Bing Liu , Xiang Li , Xiaofeng Zhu , Nan Wu

The rise of large language models (LLMs) has marked a pivotal shift in the field of natural language processing (NLP). LLMs have revolutionized a multitude of domains, and they have made a significant impact in the medical field. Large…

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