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Traditional Chinese Medicine (TCM) represents a rich repository of ancient medical knowledge that continues to play an important role in modern healthcare. Due to the complexity and breadth of the TCM literature, the integration of AI…

Information Retrieval · Computer Science 2025-06-30 Jinglin He , Yunqi Guo , Lai Kwan Lam , Waikei Leung , Lixing He , Yuanan Jiang , Chi Chiu Wang , Guoliang Xing , Hongkai Chen

Background: Retrieval augmented generation (RAG) technology can empower large language models (LLMs) to generate more accurate, professional, and timely responses without fine tuning. However, due to the complex reasoning processes and…

Computation and Language · Computer Science 2026-02-27 Jianmin Li , Ying Chang , Su-Kit Tang , Yujia Liu , Yanwen Wang , Shuyuan Lin , Binkai Ou

The surge of large language models (LLMs) has driven significant progress in medical applications, including traditional Chinese medicine (TCM). However, current medical LLMs struggle with TCM diagnosis and syndrome differentiation due to…

Computation and Language · Computer Science 2025-10-01 Sibo Wei , Xueping Peng , Yi-Fei Wang , Tao Shen , Jiasheng Si , Weiyu Zhang , Fa Zhu , Athanasios V. Vasilakos , Wenpeng Lu , Xiaoming Wu , Yinglong Wang

Traditional Chinese Medicine (TCM) involves complex compatibility mechanisms characterized by multi-component and multi-target interactions, which are challenging to quantify. To address this challenge, we applied graph artificial…

Machine Learning · Computer Science 2024-12-11 Jingqi Zeng , Xiaobin Jia

Although large language models perform well in understanding and responding to user intent, their performance in specialized domains such as Traditional Chinese Medicine (TCM) remains limited due to lack of expertise. In addition,…

Computation and Language · Computer Science 2024-11-05 Song Yu , Xiaofei Xu , Fangfei Xu , Li Li

Large Language Models (LLMs) have demonstrated remarkable capabilities in modern medicine, yet their application in Traditional Chinese Medicine (TCM) remains severely limited by the absence of standardized benchmarks and the scarcity of…

Computation and Language · Computer Science 2025-12-29 Zihao Cheng , Yuheng Lu , Huaiqian Ye , Zeming Liu , Minqi Wang , Jingjing Liu , Zihan Li , Wei Fan , Yuanfang Guo , Ruiji Fu , Shifeng She , Gang Wang , Yunhong Wang

Traditional Chinese Medicine (TCM), with a history spanning over two millennia, plays a role in global healthcare. However, applying large language models (LLMs) to TCM remains challenging due to its reliance on holistic reasoning, implicit…

Computation and Language · Computer Science 2025-10-21 Jiacheng Xie , Yang Yu , Yibo Chen , Hanyao Zhang , Lening Zhao , Jiaxuan He , Lei Jiang , Xiaoting Tang , Guanghui An , Dong Xu

Natural medicines, particularly Traditional Chinese Medicine (TCM), are gaining global recognition for their therapeutic potential in addressing human symptoms and diseases. TCM, with its systematic theories and extensive practical…

Computation and Language · Computer Science 2025-05-20 Zhi Liu , Tao Yang , Jing Wang , Yexin Chen , Zhan Gao , Jiaxi Yang , Kui Chen , Bingji Lu , Xiaochen Li , Changyong Luo , Yan Li , Xiaohong Gu , Peng Cao

We introduce a novel graph-based Retrieval-Augmented Generation (RAG) framework specifically designed for the medical domain, called \textbf{MedGraphRAG}, aimed at enhancing Large Language Model (LLM) capabilities for generating…

Computer Vision and Pattern Recognition · Computer Science 2024-10-17 Junde Wu , Jiayuan Zhu , Yunli Qi , Jingkun Chen , Min Xu , Filippo Menolascina , Vicente Grau

Despite the success of large language models (LLMs) in various domains, their potential in Traditional Chinese Medicine (TCM) remains largely underexplored due to two critical barriers: (1) the scarcity of high-quality TCM data and (2) the…

Computation and Language · Computer Science 2025-08-21 Junying Chen , Zhenyang Cai , Zhiheng Liu , Yunjin Yang , Rongsheng Wang , Qingying Xiao , Xiangyi Feng , Zhan Su , Jing Guo , Xiang Wan , Guangjun Yu , Haizhou Li , Benyou Wang

Traditional Chinese medicine (TCM) has relied on specific combinations of herbs in prescriptions to treat various symptoms and signs for thousands of years. Predicting TCM prescriptions poses a fascinating technical challenge with…

Computation and Language · Computer Science 2024-12-13 Xingzhi Zhou , Xin Dong , Chunhao Li , Yuning Bai , Yulong Xu , Ka Chun Cheung , Simon See , Xinpeng Song , Runshun Zhang , Xuezhong Zhou , Nevin L. Zhang

Enhancing interrogation capabilities in Traditional Chinese Medicine (TCM) diagnosis through multi-turn dialogues and knowledge graphs presents a significant challenge for modern AI systems. Current large language models (LLMs), despite…

Artificial Intelligence · Computer Science 2025-07-08 Zewen Sun , Ruoxiang Huang , Jiahe Feng , Rundong Kong , Yuqian Wang , Hengyu Liu , Ziqi Gong , Yuyuan Qin , Yingxue Wang , Yu Wang

The practice of Traditional Chinese Medicine (TCM) requires profound expertise and extensive clinical experience. While Large Language Models (LLMs) offer significant potential in this domain, current TCM-oriented LLMs suffer two critical…

Computation and Language · Computer Science 2026-01-21 Yehan Yang , Tianhao Ma , Ruotai Li , Xinhan Zheng , Guodong Shan

Large language models (LLMs) have demonstrated remarkable capabilities in a wide range of tasks, yet their application to specialized domains remains challenging due to the need for deep expertise. Retrieval-Augmented generation (RAG) has…

Computation and Language · Computer Science 2025-09-30 Qinggang Zhang , Shengyuan Chen , Yuanchen Bei , Zheng Yuan , Huachi Zhou , Zijin Hong , Hao Chen , Yilin Xiao , Chuang Zhou , Junnan Dong , Yi Chang , Xiao Huang

Large language models (LLMs) have significantly advanced the field of natural language generation. However, they frequently generate unverified outputs, which compromises their reliability in critical applications. In this study, we propose…

Computation and Language · Computer Science 2025-02-18 Alexandru Lecu , Adrian Groza , Lezan Hawizy

Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

Traditional Chinese Medicine (TCM) has seen increasing adoption in healthcare, with specialized Large Language Models (LLMs) emerging to support clinical applications. A fundamental requirement for these models is accurate identification of…

Computation and Language · Computer Science 2025-04-16 Sifan Li , Yujun Cai , Bryan Hooi , Nanyun Peng , Yiwei Wang

Generative large language models (LLMs) have shown great success in various applications, including question-answering (QA) and dialogue systems. However, in specialized domains like traditional Chinese medical QA, these models may perform…

Computation and Language · Computer Science 2023-09-06 Yang Tan , Mingchen Li , Zijie Huang , Huiqun Yu , Guisheng Fan

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin

Traditional Chinese Medicine (TCM) presents a rich and structurally unique knowledge system that challenges conventional applications of large language models (LLMs). Although previous TCM-specific LLMs have shown progress through…

Computation and Language · Computer Science 2025-10-21 Jiacheng Xie , Shuai Zeng , Yang Yu , Xiaoting Tang , Guanghui An , Dong Xu
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