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In recent years, Variational Quantum Algorithms (VQAs) have emerged as a promising approach for solving optimization problems on quantum computers in the NISQ era. However, one limitation of VQAs is their reliance on fixed-structure…

Quantum Physics · Physics 2026-03-03 Gloria Turati , Maurizio Ferrari Dacrema , Paolo Cremonesi

The genetic code has been shown to be very error robust compared to randomly selected codes, but to be significantly less error robust than a certain code found by a heuristic algorithm. We formulate this optimisation problem as a Quadratic…

Quantitative Methods · Quantitative Biology 2015-03-13 Harry Buhrman , Peter T. S. van der Gulik , Steven M. Kelk , Wouter M. Koolen , Leen Stougie

Variational algorithms are promising candidates to be implemented on near-term quantum computers. The variational quantum eigensolver (VQE) is a prominent example, where a parametrized trial state of the quantum mechanical wave function is…

The design of biological systems is hindered by uncertainty arising from both intrinsic stochasticity of biomolecular reactions and variability across laboratory or experimental conditions. In this work, we present a sequential framework to…

Machine Learning · Computer Science 2026-05-08 Michal Kobiela , Diego A. Oyarzún , Michael U. Gutmann

We present a new optimization method for small-to-intermediate scale variational algorithms on noisy near-term quantum processors which uses a Gaussian process surrogate model equipped with a classically-evaluated quantum kernel.…

Quantum Physics · Physics 2023-08-16 Alistair W. R. Smith , A. J. Paige , M. S. Kim

State-of-the-art noisy digital quantum computers can only execute short-depth quantum circuits. Variational algorithms are a promising route to unlock the potential of noisy quantum computers since the depth of the corresponding circuits…

Long-distance quantum communication via entanglement distribution is of great importance for the quantum internet. However, scaling up to such long distances has proved challenging due to the loss of photons, which grows exponentially with…

Molecular simulations with the variational quantum eigensolver (VQE) are a promising application for emerging noisy intermediate-scale quantum computers. Constructing accurate molecular ans\"atze that are easy to optimize and implemented by…

Parameterized quantum circuits are a promising technology for achieving a quantum advantage. An important application is the variational simulation of time evolution of quantum systems. To make the most of quantum hardware, variational…

Quantum Physics · Physics 2021-07-28 Marcello Benedetti , Mattia Fiorentini , Michael Lubasch

Software vulnerabilities continue to undermine the reliability and security of modern systems, particularly as software complexity outpaces the capabilities of traditional detection methods. This study introduces a genetic algorithm-based…

Software Engineering · Computer Science 2025-08-11 Yanusha Mehendran , Maolin Tang , Yi Lu

Deep neural networks (DNN) have been used successfully in many scientific problems for their high prediction accuracy, but their application to genetic studies remains challenging due to their poor interpretability. In this paper, we…

Machine Learning · Computer Science 2021-10-01 Peyman H. Kassani , Fred Lu , Yann Le Guen , Zihuai He

Quantum variational circuits have gained significant attention due to their applications in the quantum approximate optimization algorithm and quantum machine learning research. This work introduces a novel class of classical probabilistic…

Quantum Physics · Physics 2025-09-17 Gal Weitz , Lirandë Pira , Chris Ferrie , Joshua Combes

Quantum Neural Networks (QNNs) offer a promising framework for integrating quantum computing principles into machine learning, yet their practical capabilities and limitations remain insufficiently studied. In this work, we systematically…

Quantum Physics · Physics 2026-03-31 Martyna Czuba , Patrick Holzer , Hein Zay Yar Oo

Variational methods offer a highly promising route to exploiting quantum computers for chemistry tasks. Here we employ methods described in a sister paper to the present report, entitled ab initio machine synthesis of quantum circuits, in…

Quantum Physics · Physics 2023-08-09 Cica Gustiani , Richard Meister , Simon C. Benjamin

Variational quantum algorithms (VQAs), as one of the most promising routes in the noisy intermediate-scale quantum (NISQ) era, offer various potential applications while also confront severe challenges due to near-term quantum hardware…

Quantum Physics · Physics 2024-12-12 Shi-Xin Zhang , Jiaqi Miao , Chang-Yu Hsieh

A random-key genetic algorithm is an evolutionary metaheuristic for discrete and global optimization. Each solution is encoded as a vector of N random keys, where a random key is a real number randomly generated in the continuous interval…

Neural and Evolutionary Computing · Computer Science 2026-01-13 Mariana A. Londe , Luciana S. Pessoa , Carlos E. Andrade , José F. Gonçalves , Mauricio G. C. Resende

Variational quantum algorithms have been advocated as promising candidates to solve combinatorial optimization problems on near-term quantum computers. Their methodology involves transforming the optimization problem into a quadratic…

Quantum Physics · Physics 2023-08-01 Zoé Verchère , Sourour Elloumi , Andrea Simonetto

The variational quantum eigensolver is a promising way to solve the Schr\"odinger equation on a noisy intermediate-scale quantum (NISQ) computer, while its success relies on a well-designed wavefunction ansatz. Compared to physically…

Quantum Physics · Physics 2023-01-20 Xiongzhi Zeng , Yi Fan , Jie Liu , Zhenyu Li , Jinlong Yang

The variational quantum eigensolver (VQE) is a hybrid quantum-classical algorithm designed for current and near-term quantum devices. Despite its initial success, there is a lack of understanding involving several of its key aspects. There…

Quantum Physics · Physics 2023-03-22 Manpreet Singh Jattana , Fengping Jin , Hans De Raedt , Kristel Michielsen

Integrated photonic circuits play a crucial role in implementing quantum information processing in the noisy intermediate-scale quantum (NISQ) era. Variational learning is a promising avenue that leverages classical optimization techniques…