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General results from statistical learning theory suggest to understand not only brain computations, but also brain plasticity as probabilistic inference. But a model for that has been missing. We propose that inherently stochastic features…

Neural and Evolutionary Computing · Computer Science 2016-02-17 David Kappel , Stefan Habenschuss , Robert Legenstein , Wolfgang Maass

Neurodegenerative diseases are characterized by the accumulation of misfolded proteins and widespread disruptions in brain function. Computational modeling has advanced our understanding of these processes, but efforts have traditionally…

Fracture networks are ubiquitous in nature, spanning scales from millimeter-sized cracks in botanical peels to hundred-kilometer-long lineae on planetary satellites. The propagation of a crack is a complex, nonlinear phenomenon governed by…

Soft Condensed Matter · Physics 2026-03-25 Naoki Sekiya , Yuri Akiba , Kai Kageyama , Hokuto Nagatakiya , Ryuichi Tarumi , Tomohiko G. Sano

Understanding the intricate architecture of brain networks and its connection to brain function is essential for deciphering the underlying principles of cognition and disease. While traditional graph-theoretical measures have been widely…

Chaotic Dynamics · Physics 2025-11-13 Anca Radulescu , Eva Kaslik , Alexandru Fikl , Johan Nakuci , Sarah Muldoon , Michael Anderson

Surface elasticity is central to understanding the mechanics and stability of surfaces and interfaces. It is characterized by quantities such as surface tension, residual surface stress, and surface stiffness, however their analytical…

Materials Science · Physics 2025-12-03 Saaketh Desai , Prasad P. Iyer , Remi Dingreville

Deep learning is the mainstream technique for many machine learning tasks, including image recognition, machine translation, speech recognition, and so on. It has outperformed conventional methods in various fields and achieved great…

Machine Learning · Computer Science 2018-06-01 Na Lei , Zhongxuan Luo , Shing-Tung Yau , David Xianfeng Gu

A machine learning approach is presented to accelerate the computation of block polymer morphology evolution for large domains over long timescales. The strategy exploits the separation of characteristic times between coarse-grained…

Chemical Physics · Physics 2023-09-01 Hyun Park , Boyuan Yu , Juhae Park , Ge Sun , Emad Tajkhorshid , Juan J. de Pablo , Ludwig Schneider

Embryogenesis is a multiscale process during which developmental symmetry breaking transitions give rise to complex multicellular organisms. Recent advances in high-resolution live-cell microscopy provide unprecedented insights into the…

Biological Physics · Physics 2023-06-27 Nicolas Romeo , Alasdair Hastewell , Alexander Mietke , Jörn Dunkel

Conventional visualization media such as MRI prints and computer screens are inherently two dimensional, making them incapable of displaying true 3D volume data sets. By applying only transparency or intensity projection, and ignoring…

Graphics · Computer Science 2007-05-23 Gibby Koldenhof

Being able to adequately process and combine data arising from different sites is crucial in neuroimaging, but is difficult, owing to site, sequence and acquisition-parameter dependent biases. It is important therefore to design algorithms…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Pedro Borges , Richard Shaw , Thomas Varsavsky , Kerstin Klaser , David Thomas , Ivana Drobnjak , Sebastien Ourselin , M Jorge Cardoso

Multi-modal medical image segmentation plays an essential role in clinical diagnosis. It remains challenging as the input modalities are often not well-aligned spatially. Existing learning-based methods mainly consider sharing trainable…

Computer Vision and Pattern Recognition · Computer Science 2021-01-06 Jingkun Chen , Wenqi Li , Hongwei Li , Jianguo Zhang

We studied the structural alterations between healthy and diseased brain tissues using a multiparametric framework combining fractal analysis, fractal functional transformation, multifractal analysis, and the Inverse Participation Ratio…

Medical Physics · Physics 2025-12-09 Mousa Alrubayan , Santanu Maity , Prabhakar Pradhan

Brain morphometry study plays a fundamental role in neuroimaging research. In this work, we propose a novel method for brain surface morphometry analysis based on surface foliation theory. Given brain cortical surfaces with automatically…

Computational Geometry · Computer Science 2018-09-11 Chengfeng Wen , Na Lei , Ming Ma , Xin Qi , Wen Zhang , Yalin Wang , David Xianfeng Gu

Brain-inspired learning models attempt to mimic the cortical architecture and computations performed in the neurons and synapses constituting the human brain to achieve its efficiency in cognitive tasks. In this work, we present…

Neural and Evolutionary Computing · Computer Science 2017-03-21 Priyadarshini Panda , Gopalakrishnan Srinivasan , Kaushik Roy

This paper describes how realistic neuromorphic networks can have their connectivity fully characterized in analytical fashion. By assuming that all neurons have the same shape and are regularly distributed along the two-dimensional…

Disordered Systems and Neural Networks · Physics 2007-05-23 Luciano da Fontoura Costa , Marconi Soares Barbosa

Metal additive manufacturing enables unprecedented design freedom and the production of customized, complex components. However, the rapid melting and solidification dynamics inherent to metal AM processes generate heterogeneous,…

Machine Learning · Computer Science 2025-05-05 D. Patel , R. Sharma , Y. B. Guo

The process of morphogenesis, which can be defined as an evolution of the form of an organism, is one of the most intriguing mysteries in the life sciences. It is clear, that gene expression patterns cannot explain the development of the…

Other Quantitative Biology · Quantitative Biology 2013-07-23 Nadya Morozova , Mikhail Shubin

Determining the different conformational states of a protein and the transition paths between them is key to fully understanding the relationship between biomolecular structure and function. This can be accomplished by sampling protein…

Biological Physics · Physics 2021-03-24 Venkata K. Ramaswamy , Chris G. Willcocks , Matteo T. Degiacomi

Integrating task-relevant information into neural representations is a fundamental ability of both biological and artificial intelligence systems. Recent theories have categorized learning into two regimes: the rich regime, where neural…

Machine Learning · Computer Science 2025-07-14 Chi-Ning Chou , Hang Le , Yichen Wang , SueYeon Chung

Learning in structured, multi-context, or non-stationary environments involves two orthogonal difficulties. The first is \emph{metric}: once the correct context is known, how hard is prediction within it? This is the domain of Statistical…

Machine Learning · Computer Science 2026-05-08 Xin Li