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Clinical trials traditionally employ blinding as a design mechanism to reduce the influence of placebo effects. In practice, however, it can be difficult or impossible to blind study participants and unblinded trials are common in medical…

Applications · Statistics 2016-06-22 Elias Chaibub Neto

In real-world decision making, outcomes are often delayed, meaning individuals must make multiple decisions before receiving any feedback. Moreover, feedback can be presented in different ways: it may summarize the overall results of…

Human-Computer Interaction · Computer Science 2025-05-16 Tailia Malloy , Maria Jose Ferreira , Fei Fang , Cleotilde Gonzalez

In healthcare, predictive models increasingly inform patient-level decisions, yet little attention is paid to the variability in individual risk estimates and its impact on treatment decisions. For overparameterized models, now standard in…

Machine Learning · Computer Science 2026-04-16 Elizabeth W. Miller , Jeffrey D. Blume

Marginal structural models are a popular tool for investigating the effects of time-varying treatments, but they require an assumption of no unobserved confounders between the treatment and outcome. With observational data, this assumption…

Methodology · Statistics 2021-06-10 Matthew Blackwell , Soichiro Yamauchi

We develop an analytically tractable single-step diffusion model based on a linear denoiser and present an explicit formula for the Kullback-Leibler divergence between the generated and sampling distribution, taken to be isotropic Gaussian,…

Machine Learning · Computer Science 2025-08-08 Indranil Halder

Many observational studies feature irregular longitudinal data, where the observation times are not common across individuals in the study. Further, the observation times may be related to the longitudinal outcome. In this setting, failing…

Methodology · Statistics 2024-05-27 Grace Tompkins , Joel A Dubin , Michael Wallace

In causal inference, interference occurs when the treatment of one unit may affect the outcomes of other units. The goal of this work is to serve as a guide to the use of linear outcome modeling for estimating causal effects in settings…

Methodology · Statistics 2026-04-01 Eric Tong , Salvador V. Balkus

Self-supervised sequential recommendation significantly improves recommendation performance by maximizing mutual information with well-designed data augmentations. However, the mutual information estimation is based on the calculation of…

Machine Learning · Computer Science 2023-06-21 Ziwei Fan , Zhiwei Liu , Hao Peng , Philip S Yu

We consider adaptive designs for a trial involving N individuals that we follow along T time steps. We allow for the variables of one individual to depend on its past and on the past of other individuals. Our goal is to learn a mean…

Statistics Theory · Mathematics 2021-01-20 Aurelien Bibaut , Maya Petersen , Nikos Vlassis , Maria Dimakopoulou , Mark van der Laan

Empirical work often uses treatment assigned following geographic boundaries. When the effects of treatment cross over borders, classical difference-in-differences estimation produces biased estimates for the average treatment effect. In…

Econometrics · Economics 2023-06-13 Kyle Butts

In this paper, we propose some estimators for the parameters of a statistical model based on Kullback-Leibler divergence of the survival function in continuous setting. We prove that the proposed estimators are subclass of "generalized…

Statistics Theory · Mathematics 2016-07-01 Yaser Mehrali , Majid Asadi

Segregation is a multi-scale phenomenon that requires careful measurement. A segregation index implicitly defines how the demographic compositions of locations are compared. We identify two properties -- mean-minimisation and invariance --…

Physics and Society · Physics 2026-03-17 Rohit Sahasrabuddhe , Renaud Lambiotte

In oncology phase I trials, model-assisted designs have been increasingly adopted because they enable adaptive yet operationally simple dose adjustment based on accumulating safety data, leading to a paradigm shift in dose-escalation…

Methodology · Statistics 2026-02-23 Kana Yamada , Hisato Sunami , Kentaro Takeda , Keisuke Hanada , Masahiro Kojima

The variational framework for learning inducing variables (Titsias, 2009a) has had a large impact on the Gaussian process literature. The framework may be interpreted as minimizing a rigorously defined Kullback-Leibler divergence between…

Machine Learning · Statistics 2015-12-07 Alexander G. de G. Matthews , James Hensman , Richard E. Turner , Zoubin Ghahramani

This study tackles the efficient estimation of Kullback-Leibler (KL) Divergence in Dirichlet Mixture Models (DMM), crucial for clustering compositional data. Despite the significance of DMMs, obtaining an analytically tractable solution for…

Machine Learning · Statistics 2024-03-20 Samyajoy Pal , Christian Heumann

Obtaining an accurate estimate of the underlying covariance matrix from finite sample size data is challenging due to sample size noise. In recent years, sophisticated covariance-cleaning techniques based on random matrix theory have been…

Computation · Statistics 2024-11-11 Christian Bongiorno , Lamia Lamrani

We consider models for social choice where voters rank a set of choices (or alternatives) by deliberating in small groups of size at most $k$, and these outcomes are aggregated by a social choice rule to find the winning alternative. We…

Computer Science and Game Theory · Computer Science 2025-03-21 Ashish Goel , Mohak Goyal , Kamesh Munagala

We develop a data-driven information-theoretic framework for sharp partial identification of causal effects under unmeasured confounding. Existing approaches often rely on restrictive assumptions, such as bounded or discrete outcomes;…

Machine Learning · Statistics 2026-02-24 Yonghan Jung , Bogyeong Kang

Discriminator Guidance has become a popular method for efficiently refining pre-trained Score-Matching Diffusion models. However, in this paper, we demonstrate that the standard implementation of this technique does not necessarily lead to…

Machine Learning · Computer Science 2025-06-12 Alexandre Verine , Ahmed Mehdi Inane , Florian Le Bronnec , Benjamin Negrevergne , Yann Chevaleyre

Background: Estimations of causal effects from observational data are subject to various sources of bias. One method of adjusting for the residual biases in the estimation of a treatment effect is through negative control outcomes, where…

Methodology · Statistics 2022-07-29 Hon Hwang , Juan C Quiroz , Blanca Gallego