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In computational pathology, multiple instance learning (MIL) is widely used to circumvent the computational impasse in giga-pixel whole slide image (WSI) analysis. It usually consists of two stages: patch-level feature extraction and…

Image and Video Processing · Electrical Eng. & Systems 2023-09-21 Beidi Zhao , Wenlong Deng , Zi Han , Li , Chen Zhou , Zuhua Gao , Gang Wang , Xiaoxiao Li

Multiple instance learning (MIL) has emerged as the dominant paradigm for whole slide image (WSI) analysis in computational pathology, achieving strong diagnostic performance through patch-level feature aggregation. However, existing MIL…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Yiran Song , Yikai Zhang , Shuang Zhou , Guojun Xiong , Xiaofeng Yang , Nian Wang , Fenglong Ma , Rui Zhang , Mingquan Lin

The visual examination of tissue biopsy sections is fundamental for cancer diagnosis, with pathologists analyzing sections at multiple magnifications to discern tumor cells and their subtypes. However, existing attention-based multiple…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Olga Fourkioti , Matt De Vries , Chen Jin , Daniel C. Alexander , Chris Bakal

The latent representation in learned image compression encompasses channel-wise, local spatial, and global spatial correlations, which are essential for the entropy model to capture for conditional entropy minimization. Efficiently…

Image and Video Processing · Electrical Eng. & Systems 2025-10-29 Wei Jiang , Jiayu Yang , Yongqi Zhai , Feng Gao , Ronggang Wang

Multiple Instance Learning (MIL) is a weakly-supervised problem in which one label is assigned to the whole bag of instances. An important class of MIL models is instance-based, where we first classify instances and then aggregate those…

Image and Video Processing · Electrical Eng. & Systems 2024-03-13 Łukasz Struski , Dawid Rymarczyk , Arkadiusz Lewicki , Robert Sabiniewicz , Jacek Tabor , Bartosz Zieliński

In this paper, we present a new multiple instance learning (MIL) method, called MIS-Boost, which learns discriminative instance prototypes by explicit instance selection in a boosting framework. Unlike previous instance selection based MIL…

Machine Learning · Computer Science 2011-09-13 Emre Akbas , Bernard Ghanem , Narendra Ahuja

Multiple instance learning (MIL) is a promising approach for weakly supervised classification in pathology using whole slide images (WSIs). However, conventional MIL methods such as Attention-Based Deep Multiple Instance Learning (ABMIL)…

Image and Video Processing · Electrical Eng. & Systems 2025-04-28 Hassan Keshvarikhojasteh , Mihail Tifrea , Sibylle Hess , Josien P. W. Pluim , Mitko Veta

This paper presents the first attempt to learn semantic boundary detection using image-level class labels as supervision. Our method starts by estimating coarse areas of object classes through attentions drawn by an image classification…

Computer Vision and Pattern Recognition · Computer Science 2022-12-16 Namyup Kim , Sehyun Hwang , Suha Kwak

Breast cancer prediction models for mammography assume that annotations are available for individual images or regions of interest (ROIs), and that there is a fixed number of images per patient. These assumptions do not hold in real…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Shreyasi Pathak , Jörg Schlötterer , Jeroen Geerdink , Jeroen Veltman , Maurice van Keulen , Nicola Strisciuglio , Christin Seifert

Most machine learning models for molecular property prediction rely on a single molecular representation (either a sequence, a graph, or a 3D structure) and treat molecular geometry as static. We present MolFM-Lite, a multi-modal model that…

Cell instance segmentation is a new and challenging task aiming at joint detection and segmentation of every cell in an image. Recently, many instance segmentation methods have applied in this task. Despite their great success, there still…

Computer Vision and Pattern Recognition · Computer Science 2022-08-18 Menghao Li , Wenquan Feng , Shuchang Lyu , Lijiang Chen , Qi Zhao

Identifying epileptic seizures through analysis of the electroencephalography (EEG) signal becomes a standard method for the diagnosis of epilepsy. Manual seizure identification on EEG by trained neurologists is time-consuming,…

Machine Learning · Computer Science 2019-06-07 X. Yao , X. Li , Q. Ye , Y. Huang , Q. Cheng , G. -Q. Zhang

Learning similarity is a key aspect in medical image analysis, particularly in recommendation systems or in uncovering the interpretation of anatomical data in images. Most existing methods learn such similarities in the embedding space…

Computer Vision and Pattern Recognition · Computer Science 2022-06-22 Sukesh Adiga , Jose Dolz , Herve Lombaert

Self-supervised pretraining followed by supervised fine-tuning has seen success in image recognition, especially when labeled examples are scarce, but has received limited attention in medical image analysis. This paper studies the…

Segmentation of objects in microscopy images is required for many biomedical applications. We introduce object-centric embeddings (OCEs), which embed image patches such that the spatial offsets between patches cropped from the same object…

Machine Learning · Computer Science 2023-10-13 Steffen Wolf , Manan Lalit , Henry Westmacott , Katie McDole , Jan Funke

Multi-instance learning (MIL) is a widely-applied technique in practical applications that involve complex data structures. MIL can be broadly categorized into two types: traditional methods and those based on deep learning. These…

Artificial Intelligence · Computer Science 2023-04-25 Yu-Xuan Zhang , Zhengchun Zhou , Xingxing He , Avik Ranjan Adhikary , Bapi Dutta

Multiple instance learning (MIL) is a framework for weakly supervised classification, where labels are assigned to sets of instances, i.e., bags, rather than to individual data points. This paradigm has proven effective in tasks where…

Machine Learning · Computer Science 2026-03-03 Salome Kazeminia , Carsten Marr , Bastian Rieck

Annotating cancerous regions in whole-slide images (WSIs) of pathology samples plays a critical role in clinical diagnosis, biomedical research, and machine learning algorithms development. However, generating exhaustive and accurate…

Computer Vision and Pattern Recognition · Computer Science 2022-06-09 Zhenzhen Wang , Carla Saoud , Sintawat Wangsiricharoen , Aaron W. James , Aleksander S. Popel , Jeremias Sulam

Multiple instance learning exhibits a powerful approach for whole slide image-based diagnosis in the absence of pixel- or patch-level annotations. In spite of the huge size of hole slide images, the number of individual slides is often…

Multiple-instance learning (MIL) is a paradigm of machine learning that aims to classify a set (bag) of objects (instances), assigning labels only to the bags. This problem is often addressed by selecting an instance to represent each bag,…

Human-Computer Interaction · Computer Science 2021-12-22 Sonia Castelo , Moacir Ponti , Rosane Minghim