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This study evaluates how well large language models (LLMs) can classify ICD-10 codes from hospital discharge summaries, a critical but error-prone task in healthcare. Using 1,500 summaries from the MIMIC-IV dataset and focusing on the 10…

Computation and Language · Computer Science 2025-07-08 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Addressing the complexity of accurately classifying International Classification of Diseases (ICD) codes from medical discharge summaries is challenging due to the intricate nature of medical documentation. This paper explores the use of…

Machine Learning · Computer Science 2024-11-12 Zeyd Boukhers , AmeerAli Khan , Qusai Ramadan , Cong Yang

Accurate International Classification of Diseases (ICD) coding is critical for clinical documentation, billing, and healthcare analytics, yet it remains a labour-intensive and error-prone task. Although large language models (LLMs) show…

Artificial Intelligence · Computer Science 2025-09-24 Hong-Jie Dai , Zheng-Hao Li , An-Tai Lu , Bo-Tsz Shain , Ming-Ta Li , Tatheer Hussain Mir , Kuang-Te Wang , Min-I Su , Pei-Kang Liu , Ming-Ju Tsai

Clinical coding is a critical task in healthcare, although traditional methods for automating clinical coding may not provide sufficient explicit evidence for coders in production environments. This evidence is crucial, as medical coders…

Computation and Language · Computer Science 2025-04-08 Leonor Barreiros , Isabel Coutinho , Gonçalo M. Correia , Bruno Martins

Identifying disease interconnections through manual analysis of large-scale clinical data is labor-intensive, subjective, and prone to expert disagreement. While machine learning (ML) shows promise, three critical challenges remain: (1)…

Automatically associating ICD codes with electronic health data is a well-known NLP task in medical research. NLP has evolved significantly in recent years with the emergence of pre-trained language models based on Transformers…

Computation and Language · Computer Science 2023-04-07 Yakini Tchouka , Jean-François Couchot , David Laiymani , Philippe Selles , Azzedine Rahmani

Clinical coding is the task of assigning a set of alphanumeric codes, referred to as ICD (International Classification of Diseases), to a medical event based on the context captured in a clinical narrative. The latest version of ICD,…

Computation and Language · Computer Science 2022-03-11 Cansu Sen , Bingyang Ye , Javed Aslam , Amir Tahmasebi

Large Language Models (LLMs) have become a pivotal research area, potentially making beneficial contributions in fields like healthcare where they can streamline automated billing and decision support. However, the frequent use of…

Computation and Language · Computer Science 2024-06-10 Simon A. Lee , Timothy Lindsey

Mental health has become a global priority, leading to a massive administrative burden in the coding of clinical diagnoses. This study proposes the automation of psychiatric diagnostic analysis by mapping free-text descriptions to the…

The extraction of lung lesion information from clinical and medical imaging reports is crucial for research on and clinical care of lung-related diseases. Large language models (LLMs) can be effective at interpreting unstructured text in…

Computation and Language · Computer Science 2024-11-18 Diya Li , Asim Kadav , Aijing Gao , Rui Li , Richard Bourgon

Background: Medical coding structures healthcare data for research, quality monitoring, and policy. This study assesses the potential of large language models (LLMs) to assign ICPC-2 codes using the output of a domain-specific search…

The biomedical field relies heavily on concept linking in various areas such as literature mining, graph alignment, information retrieval, question-answering, data, and knowledge integration. Although large language models (LLMs) have made…

Computation and Language · Computer Science 2023-07-04 Qinyong Wang , Zhenxiang Gao , Rong Xu

Large Language Models (LLMs) have fundamentally transformed approaches to Natural Language Processing (NLP) tasks across diverse domains. In healthcare, accurate and cost-efficient text classification is crucial, whether for clinical notes…

Computation and Language · Computer Science 2026-02-16 Hajar Sakai , Sarah S. Lam

The task of assigning diagnostic ICD codes to patient hospital admissions is typically performed by expert human coders. Efforts towards automated ICD coding are dominated by supervised deep learning models. However, difficulties in…

Artificial Intelligence · Computer Science 2023-11-14 Joseph S. Boyle , Antanas Kascenas , Pat Lok , Maria Liakata , Alison Q. O'Neil

We present MedCOD (Medical Chain-of-Dictionary), a hybrid framework designed to improve English-to-Spanish medical translation by integrating domain-specific structured knowledge into large language models (LLMs). MedCOD integrates…

Computation and Language · Computer Science 2025-09-22 Md Shahidul Salim , Lian Fu , Arav Adikesh Ramakrishnan , Zonghai Yao , Hong Yu

This study presents a novel two-stage Retrieve-Rank system for automated ICD-10-CM medical coding, comparing its performance against a Vanilla Large Language Model (LLM) approach. Evaluating both systems on a dataset of 100 single-term…

Information Retrieval · Computer Science 2024-07-19 Keith Kwan

Accurate clinical coding is essential for healthcare documentation, billing, and decision-making. While prior work shows that off-the-shelf LLMs struggle with this task, evaluations based on exact match metrics often overlook errors where…

Computation and Language · Computer Science 2025-10-10 Zhangdie Yuan , Han-Chin Shing , Mitch Strong , Chaitanya Shivade

Europe's healthcare systems require enhanced interoperability and digitalization, driving a demand for innovative solutions to process legacy clinical data. This paper presents the results of our project, which aims to leverage Large…

Computation and Language · Computer Science 2025-07-09 Aynur Guluzade , Naguib Heiba , Zeyd Boukhers , Florim Hamiti , Jahid Hasan Polash , Yehya Mohamad , Carlos A Velasco

To address the limitations of Large Language Models (LLMs) in the International Classification of Diseases (ICD) coding task, where they often produce inaccurate and incomplete prediction results due to the high-dimensional and skewed…

Computation and Language · Computer Science 2024-08-15 Rumeng Li , Xun Wang , Hong Yu

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi
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