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Large language models (LLMs) face significant challenges in specialized biomedical tasks due to the inherent complexity of medical reasoning and the sensitive nature of clinical data. Existing LLMs often struggle with intricate medical…

Computation and Language · Computer Science 2026-05-12 Zongxian Yang , Jiayu Qian , Kay Chen Tan , Hau-San Wong , Yulong Chen , Haoyu Zhang , Zhi-An Huang

Large Language Models (LLMs) offer state-of-the-art performance in natural language understanding and generation tasks. However, the deployment of leading commercial models for specialized tasks, such as e-commerce, is often hindered by…

Artificial Intelligence · Computer Science 2025-10-28 Josip Tomo Licardo , Nikola Tankovic

Large Language Models (LLMs) face significant deployment challenges due to their substantial resource requirements. While low-bit quantized weights can reduce memory usage and improve inference efficiency, current hardware lacks native…

Machine Learning · Computer Science 2025-06-10 Pengxiang Zhao , Xiaoming Yuan

The rapid advancement of large language models, such as the Generative Pre-trained Transformer (GPT) series, has had significant implications across various disciplines. In this study, we investigate the potential of the state-of-the-art…

Computation and Language · Computer Science 2023-09-06 Yunhao Yang , Anshul Tomar

Reliable uncertainty quantification is a first step towards building explainable, transparent, and accountable artificial intelligent systems. Recent progress in Bayesian deep learning has made such quantification realizable. In this paper,…

Computation and Language · Computer Science 2018-11-20 Yijun Xiao , William Yang Wang

Quantization has emerged as a promising technique for improving the memory and computational efficiency of large language models (LLMs). Though the trade-off between performance and efficiency is well-known, there is still much to be…

Machine Learning · Computer Science 2024-03-12 Zhuocheng Gong , Jiahao Liu , Jingang Wang , Xunliang Cai , Dongyan Zhao , Rui Yan

Large Language Models (LLMs) are powerful tools for modern applications, but their computational demands limit accessibility. Quantization offers efficiency gains, yet its impact on safety and trustworthiness remains poorly understood. To…

Cryptography and Security · Computer Science 2025-07-01 Artyom Kharinaev , Viktor Moskvoretskii , Egor Shvetsov , Kseniia Studenikina , Bykov Mikhail , Evgeny Burnaev

Large Language Models (LLMs) have advanced rapidly but face significant memory demands. While quantization has shown promise for LLMs, current methods typically require lengthy training to alleviate the performance degradation from…

Artificial Intelligence · Computer Science 2024-05-31 Ke Yi , Yuhui Xu , Heng Chang , Chen Tang , Yuan Meng , Tong Zhang , Jia Li

Large language models (LLMs) can capture rich representations of concepts that are useful for real-world tasks. However, language alone is limited. While existing LLMs excel at text-based inferences, health applications require that models…

Computation and Language · Computer Science 2023-05-26 Xin Liu , Daniel McDuff , Geza Kovacs , Isaac Galatzer-Levy , Jacob Sunshine , Jiening Zhan , Ming-Zher Poh , Shun Liao , Paolo Di Achille , Shwetak Patel

Large language models (LLMs) show promise for improving the efficiency of qualitative analysis in large, multi-site health-services research. Yet methodological guidance for LLM integration into qualitative analysis and evidence of their…

Computation and Language · Computer Science 2026-01-22 Sasha Ronaghi , Emma-Louise Aveling , Maria Levis , Rachel Lauren Ross , Emily Alsentzer , Sara Singer

As Deep Neural Networks (DNNs) rapidly advance in various fields, including speech verification, they typically involve high computational costs and substantial memory consumption, which can be challenging to manage on mobile systems.…

Audio and Speech Processing · Electrical Eng. & Systems 2024-07-15 Yeona Hong , Woo-Jin Chung , Hong-Goo Kang

Recent work has shown that scaling large language models (LLMs) improves their alignment with human brain activity, yet it remains unclear what drives these gains and which representational properties are responsible. Although larger models…

Large Language Models (LLMs) are increasingly being deployed on edge devices for long-context settings, creating a growing need for fast and efficient long-context inference. In these scenarios, the Key-Value (KV) cache is the primary…

Large Language Models (LLMs) are expected to significantly contribute to patient care, diagnostics, and administrative processes. Emerging biomedical LLMs aim to address healthcare-specific challenges, including privacy demands and…

Computation and Language · Computer Science 2025-10-14 Amin Dada , Marie Bauer , Amanda Butler Contreras , Osman Alperen Koraş , Constantin Marc Seibold , Kaleb E Smith , Jens Kleesiek

Fine-tuning large language models (LLMs) is often constrained by the computational costs of processing massive datasets. We propose \textbf{QLESS} (Quantized Low-rank Gradient Similarity Search), which integrates gradient quantization with…

Recent breakthroughs in large language models (LLMs) offer unprecedented natural language understanding and generation capabilities. However, existing surveys on LLMs in biomedicine often focus on specific applications or model…

Large Language Models (LLMs) have seen great advance in both academia and industry, and their popularity results in numerous open-source frameworks and techniques in accelerating LLM pre-training, fine-tuning, and inference. Training and…

Performance · Computer Science 2023-12-04 Longteng Zhang , Xiang Liu , Zeyu Li , Xinglin Pan , Peijie Dong , Ruibo Fan , Rui Guo , Xin Wang , Qiong Luo , Shaohuai Shi , Xiaowen Chu

Transformer based large language models have achieved tremendous success. However, the significant memory and computational costs incurred during the inference process make it challenging to deploy large models on resource-constrained…

Computation and Language · Computer Science 2024-02-16 Wenxiao Wang , Wei Chen , Yicong Luo , Yongliu Long , Zhengkai Lin , Liye Zhang , Binbin Lin , Deng Cai , Xiaofei He

This paper introduces a system that integrates large language models (LLMs) into the clinical trial retrieval process, enhancing the effectiveness of matching patients with eligible trials while maintaining information privacy and allowing…

Information Retrieval · Computer Science 2024-11-01 Georgios Peikos , Pranav Kasela , Gabriella Pasi

Large Language Models (LLMs) have distinguished themselves with outstanding performance in complex language modeling tasks, yet they come with significant computational and storage challenges. This paper explores the potential of…

Machine Learning · Computer Science 2024-10-17 Sayeh Sharify , Utkarsh Saxena , Zifei Xu , Wanzin Yazar , Ilya Soloveychik , Xin Wang