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Synthetic medical data which preserves privacy while maintaining utility can be used as an alternative to real medical data, which has privacy costs and resource constraints associated with it. At present, most models focus on generating…

Machine Learning · Computer Science 2019-11-28 Saloni Dash , Ritik Dutta , Isabelle Guyon , Adrien Pavao , Andrew Yale , Kristin P. Bennett

We introduce the DP-auto-GAN framework for synthetic data generation, which combines the low dimensional representation of autoencoders with the flexibility of Generative Adversarial Networks (GANs). This framework can be used to take in…

Machine Learning · Computer Science 2020-12-11 Uthaipon Tantipongpipat , Chris Waites , Digvijay Boob , Amaresh Ankit Siva , Rachel Cummings

Clinical trials face mounting challenges: fragmented patient populations, slow enrollment, and unsustainable costs, particularly for late phase trials in oncology and rare diseases. While external control arms built from real-world data…

Machine Learning · Computer Science 2025-11-21 Perrine Chassat , Van Tuan Nguyen , Lucas Ducrot , Emilie Lanoy , Agathe Guilloux

Synthetic data has been hailed as the silver bullet for privacy preserving data analysis. If a record is not real, then how could it violate a person's privacy? In addition, deep-learning based generative models are employed successfully to…

Machine Learning · Computer Science 2023-07-14 Benedikt Groß , Gerhard Wunder

Machine learning heavily relies on data, but real-world applications often encounter various data-related issues. These include data of poor quality, insufficient data points leading to under-fitting of machine learning models, and…

Machine Learning · Computer Science 2025-04-07 Yingzhou Lu , Lulu Chen , Yuanyuan Zhang , Minjie Shen , Huazheng Wang , Xiao Wang , Capucine van Rechem , Tianfan Fu , Wenqi Wei

High-quality training data is critical to the performance of machine learning models, particularly Large Language Models (LLMs). However, obtaining real, high-quality data can be challenging, especially for smaller organizations and…

Machine Learning · Computer Science 2025-06-24 Cristian Del Gobbo

Electronic Health Records (EHRs) are rich sources of patient-level data, offering valuable resources for medical data analysis. However, privacy concerns often restrict access to EHRs, hindering downstream analysis. Current EHR…

Machine Learning · Computer Science 2024-12-03 Muhang Tian , Bernie Chen , Allan Guo , Shiyi Jiang , Anru R. Zhang

Acquiring large quantities of data and annotations is known to be effective for developing high-performing deep learning models, but is difficult and expensive to do in the healthcare context. Adding synthetic training data using generative…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Menghan Yu , Sourabh Kulhare , Courosh Mehanian , Charles B Delahunt , Daniel E Shea , Zohreh Laverriere , Ishan Shah , Matthew P Horning

Synthetic data generation (SDG) is a promising approach for enabling data sharing in biomedical studies while preserving patient privacy. Yet, state-of-the-art generative models often require large datasets and complex training procedures,…

Machine Learning · Computer Science 2026-01-27 Natalia Espinosa-Dice , Nicholas J. Jackson , Chao Yan , Aaron Lee , Bradley A. Malin

Background: Synthetic data has been proposed as a solution for sharing anonymized versions of sensitive biomedical datasets. Ideally, synthetic data should preserve the structure and statistical properties of the original data, while…

Machine Learning · Computer Science 2024-10-24 Ileana Montoya Perez , Parisa Movahedi , Valtteri Nieminen , Antti Airola , Tapio Pahikkala

Synthetic data from generative models emerges as the privacy-preserving data sharing solution. Such a synthetic data set shall resemble the original data without revealing identifiable private information. Till date, the prior focus on…

Machine Learning · Computer Science 2025-07-23 Chaoyi Zhu , Jiayi Tang , Juan F. Pérez , Marten van Dijk , Lydia Y. Chen

Due to privacy issues and limited amount of publicly available labeled datasets in the domain of medical imaging, we propose an image generation pipeline to synthesize 3D echocardiographic images with corresponding ground truth labels, to…

Image and Video Processing · Electrical Eng. & Systems 2024-03-11 Cristiana Tiago , Andrew Gilbert , Ahmed S. Beela , Svein Arne Aase , Sten Roar Snare , Jurica Sprem

In this work, we develop a privacy-by-design generative model for synthesizing the activity diary of the travel population using state-of-art deep learning approaches. This proposed approach extends literature on population synthesis by…

Machine Learning · Computer Science 2021-01-01 Godwin Badu-Marfo , Bilal Farooq , Zachary Patterson

Survival analysis studies time-modeling techniques for an event of interest occurring for a population. Survival analysis found widespread applications in healthcare, engineering, and social sciences. However, the data needed to train…

Machine Learning · Computer Science 2023-02-22 Alberto Archetti , Eugenio Lomurno , Francesco Lattari , André Martin , Matteo Matteucci

Synthetic data serves as an alternative in training machine learning models, particularly when real-world data is limited or inaccessible. However, ensuring that synthetic data mirrors the complex nuances of real-world data is a challenging…

Machine Learning · Computer Science 2023-10-27 Lasse Hansen , Nabeel Seedat , Mihaela van der Schaar , Andrija Petrovic

The use of synthetic data in health applications raises privacy concerns, yet the lack of open frameworks for privacy evaluations has slowed its adoption. A major challenge is the absence of accessible benchmark datasets for evaluating…

Machine Learning · Computer Science 2026-01-21 Bing Hu , Yixin Li , Asma Bahamyirou , Helen Chen

Survival analysis, time-to-event analysis, is an important problem in healthcare since it has a wide-ranging impact on patients and palliative care. Many survival analysis methods have assumed that the survival data is centrally available…

Machine Learning · Computer Science 2022-07-13 Md Mahmudur Rahman , Sanjay Purushotham

Recent years have witnessed a surge in the popularity of Machine Learning (ML), applied across diverse domains. However, progress is impeded by the scarcity of training data due to expensive acquisition and privacy legislation. Synthetic…

Machine Learning · Computer Science 2024-02-05 André Bauer , Simon Trapp , Michael Stenger , Robert Leppich , Samuel Kounev , Mark Leznik , Kyle Chard , Ian Foster

Deep learning in cardiac MRI (CMR) is fundamentally constrained by both data scarcity and privacy regulations. This study systematically benchmarks three generative architectures: Denoising Diffusion Probabilistic Models (DDPM), Latent…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Madhura Edirisooriya , Dasuni Kawya , Ishan Kumarasinghe , Isuri Devindi , Mary M. Maleckar , Roshan Ragel , Isuru Nawinne , Vajira Thambawita

Synthetic data has gained significant momentum thanks to sophisticated machine learning tools that enable the synthesis of high-dimensional datasets. However, many generation techniques do not give the data controller control over what…

Cryptography and Security · Computer Science 2022-11-22 Florimond Houssiau , Samuel N. Cohen , Lukasz Szpruch , Owen Daniel , Michaela G. Lawrence , Robin Mitra , Henry Wilde , Callum Mole
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