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The heart is a vital organ that relies on the orchestrated propagation of electrical stimuli to coordinate each heart beat. Abnormalities in the heart's electrical behaviour can be managed with a cardiac pacemaker. Recently, the closed-loop…

Systems and Control · Computer Science 2016-03-21 Eugene Yip , Sidharta Andalam , Partha S. Roop , Avinash Malik , Mark Trew , Weiwei Ai , Nitish Patel

Computational modelling offers a cost-effective and time-efficient alternative to experimental studies in biomedical engineering. In cardiac electro-mechanics, finite element method (FEM)-based simulations provide valuable insights into…

Computational Engineering, Finance, and Science · Computer Science 2025-08-20 Tan Tran , Denisa Martonova , Sigrid Leyendecker

This paper proposes a data-driven model for solving the inverse problem of electrocardiography, the mathematical problem that forms the basis of electrocardiographic imaging (ECGI). We present a conditional diffusion framework that learns a…

Machine Learning · Computer Science 2026-01-27 Ramiro Valdes Jara , Adam Meyers

The numerical tools to simulate the bidomain model in cardiac electrophysiology are constantly developing due to the great clinical interest and scientific advances in mathematical models and computational power. The bidomain model consists…

Numerical Analysis · Mathematics 2025-11-03 Gopika P B , Peter Bastian , Nagaiah Chamakuri

Cardiac arrhythmias are a major cause of morbidity and mortality increasing the risk of stroke, heart failure, and sudden cardiac death. Imageless electrocardiographic imaging (ECGI) provides a non invasive alternative to electrical mapping…

Virtual heart models have been proposed to enhance the safety of implantable cardiac devices through closed loop validation. To communicate with a virtual heart, devices have been driven by cardiac signals at specific sites. As a result,…

Systems and Control · Computer Science 2017-03-06 Weiwei Ai , Nitish Patel , Partha Roop , Avinash Malik , Nathan Allen , Mark L. Trew

The stomach plays a central role in digestion through coordinated muscle contractions, known as gastric peristalsis, driven by slow-wave electrophysiology. Understanding this process is critical for treating motility disorders such as…

Computational Engineering, Finance, and Science · Computer Science 2025-12-15 Maire S. Henke , Sebastian Brandstaeter , Sebastian L. Fuchs , Roland C. Aydin , Alessio Gizzi , Christian J. Cyron

We study properties of the human electrocardiogram under the working hypothesis that fluctuations beyond the regular structure of single cardiac cycles are unpredictable. On this background we discuss the possibility to use the phase space…

chao-dyn · Physics 2009-10-31 Marcus Richter , Thomas Schreiber

Developing new methods for predicting electromagnetic instabilities in cardiac activity is of primary importance. However, we still need a comprehensive view of the heart's magnetic activity at the tissue scale. To fill this gap, we present…

The human heart is a complex system exhibiting stochastic nature, as reflected in electrocardiogram (ECG) signals. ECG signal is a weak, non-stationary, and nonlinear signal, which indicates the health of a heart in terms of temporal…

Signal Processing · Electrical Eng. & Systems 2020-02-11 Chiranjit Maji , Pratyay Sengupta , Anandi Batabyal , Hirok Chaudhuri

Left ventricular (LV) stiffness and contractility, characterized by the end-diastolic and end-systolic pressure-volume relationships (EDPVR & ESPVR), are two important indicators of the performance of the human heart. Although much research…

Medical Physics · Physics 2023-08-22 Yunxiao Zhang , Moritz Kalhöfer-Köchling , Eberhard Bodenschatz , Yong Wang

Purpose: To develop a MRI acquisition and reconstruction framework for volumetric cine visualisation of the fetal heart and great vessels in the presence of maternal and fetal motion. Methods: Four-dimensional depiction was achieved using a…

We develop a minimal whole-heart model that describes cardiac electrical conduction and simulate a basic three-lead electrocardiogram (ECG). We compare our 3-lead ECG model with clinical data from a Norwegian athlete database. The results…

Tissues and Organs · Quantitative Biology 2025-06-26 João Olívia , Rui Dilão

Image-based computer simulation of cardiac function can be used to probe the mechanisms of (patho)physiology, and guide diagnosis and personalized treatment of cardiac diseases. This paradigm requires constructing simulation-ready meshes of…

Image and Video Processing · Electrical Eng. & Systems 2021-07-23 Fanwei Kong , Shawn C. Shadden

Computer-based simulations of non-invasive cardiac electrical outputs, such as electrocardiograms and body surface potential maps, usually entail severe computational costs due to the need of capturing fine-scale processes and to the…

Numerical Analysis · Mathematics 2023-08-09 Elena Zappon , Andrea Manzoni , Alfio Quarteroni

Fluid-Structure Interaction (FSI) can be investigated by means of non-linear Finite Element Models (FEM), suitable to capture large deflections of structural parts interacting with fluids, and Computational Fluid Dynamics (CFD). High…

Cardiovascular diseases are best diagnosed using multiple modalities that assess both the heart's electrical and mechanical functions. While effective, imaging techniques like echocardiography and nuclear imaging are costly and not widely…

Medical Physics · Physics 2024-10-28 Sajjad Karimi , Shirin Karimi , Amit J. Shah , Gari D. Clifford , Reza Sameni

An electrocardiogram (EKG) is a common, non-invasive test that measures the electrical activity of a patient's heart. EKGs contain useful diagnostic information about patient health that may be absent from other electronic health record…

Machine Learning · Statistics 2018-12-04 Andrew C. Miller , Ziad Obermeyer , David M. Blei , John P. Cunningham , Sendhil Mullainathan

Non-invasive assessment of the electrical activation pattern can significantly contribute to the diagnosis and treatment of cardiac arrhythmias, due to faster and safer diagnosis, improved surgical planning and easier follow-up. One…

Medical Physics · Physics 2024-01-09 Nathan Dermul , Hans Dierckx

Electrocardiogram (ECG)-based models have achieved strong performance in diagnostic tasks, yet they remain limited in modeling how cardiac dynamics evolve under external interventions. In particular, existing approaches focus primarily on…

Artificial Intelligence · Computer Science 2026-05-19 Zhikang Chen , Yue Wang , Sen Cui , Yu Zhang , Changshui Zhang , Tianling Ren , Tingting Zhu