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Causal inference is capable of estimating the treatment effect (i.e., the causal effect of treatment on the outcome) to benefit the decision making in various domains. One fundamental challenge in this research is that the treatment…

Machine Learning · Computer Science 2021-12-28 Qian Li , Zhichao Wang , Shaowu Liu , Gang Li , Guandong Xu

Ensuring robust model performance in diverse real-world scenarios requires addressing generalizability across domains with covariate shifts. However, no formal procedure exists for statistically evaluating generalizability in machine…

Machine Learning · Computer Science 2025-06-13 Daniel de Vassimon Manela , Linying Yang , Robin J. Evans

Evaluating observational estimators of causal effects demands information that is rarely available: unconfounded interventions and outcomes from the population of interest, created either by randomization or adjustment. As a result, it is…

Machine Learning · Computer Science 2024-10-29 Fredrik D. Johansson

When treatment policy estimands are of interest, clinical trials often attempt to collect patient data after intercurrent events (ICEs), although such data are often limited. Retrieved dropout imputation methods, which use pre-ICE and…

Methodology · Statistics 2026-03-31 Brendah Nansereko , Marcel Wolbers , James R. Carpenter , Jonathan W. Bartlett

The importance of Synthetic Data Generation (SDG) has increased significantly in domains where data quality is poor or access is limited due to privacy and regulatory constraints. One such domain is recruitment, where publicly available…

Machine Learning · Computer Science 2025-11-24 Andrea Iommi , Antonio Mastropietro , Riccardo Guidotti , Anna Monreale , Salvatore Ruggieri

Geophysical inverse problems are often ill-posed and admit multiple solutions. Conventional discriminative methods typically yield a single deterministic solution, which fails to model the posterior distribution, cannot generate diverse…

Causal inference from observational data can be viewed as a missing data problem arising from a hypothetical population-scale randomized trial matched to the observational study. This links a target trial protocol with a corresponding…

Methodology · Statistics 2022-07-27 Andrew Yiu , Edwin Fong , Stephen Walker , Chris Holmes

Causal inference from observational data plays critical role in many applications in trustworthy machine learning. While sound and complete algorithms exist to compute causal effects, many of them assume access to conditional likelihoods,…

Machine Learning · Computer Science 2024-11-04 Md Musfiqur Rahman , Matt Jordan , Murat Kocaoglu

Identifying latent variables and the causal structure involving them is essential across various scientific fields. While many existing works fall under the category of constraint-based methods (with e.g. conditional independence or rank…

Machine Learning · Computer Science 2026-05-21 Ignavier Ng , Xinshuai Dong , Haoyue Dai , Biwei Huang , Peter Spirtes , Kun Zhang

We develop new methods to integrate experimental and observational data in causal inference. While randomized controlled trials offer strong internal validity, they are often costly and therefore limited in sample size. Observational data,…

Econometrics · Economics 2025-11-04 Xuelin Yang , Licong Lin , Susan Athey , Michael I. Jordan , Guido W. Imbens

Content is created for a well-defined purpose, often described by a metric or signal represented in the form of structured information. The relationship between the goal (metrics) of target content and the content itself is non-trivial.…

Computation and Language · Computer Science 2022-03-29 Navita Goyal , Roodram Paneri , Ayush Agarwal , Udit Kalani , Abhilasha Sancheti , Niyati Chhaya

This paper introduces a collection of four data sets, similar to Anscombe's Quartet, that aim to highlight the challenges involved when estimating causal effects. Each of the four data sets is generated based on a distinct causal mechanism:…

Methodology · Statistics 2023-07-20 Lucy D'Agostino McGowan , Travis Gerke , Malcolm Barrett

From simulating galaxy formation to viral transmission in a pandemic, scientific models play a pivotal role in developing scientific theories and supporting government policy decisions that affect us all. Given these critical applications,…

Software Engineering · Computer Science 2023-07-03 Andrew G. Clark , Michael Foster , Benedikt Prifling , Neil Walkinshaw , Robert M. Hierons , Volker Schmidt , Robert D. Turner

The assumption that data samples are independent and identically distributed (iid) is standard in many areas of statistics and machine learning. Nevertheless, in some settings, such as social networks, infectious disease modeling, and…

Methodology · Statistics 2019-02-06 Eli Sherman , Ilya Shpitser

Dataset bias is a significant challenge in machine learning, where specific attributes, such as texture or color of the images are unintentionally learned resulting in detrimental performance. To address this, previous efforts have focused…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Donggeun Ko , Sangwoo Jo , Dongjun Lee , Namjun Park , Jaekwang Kim

Many modern applications collect data that comes in federated spirit, with data kept locally and undisclosed. Till date, most insight into the causal inference requires data to be stored in a central repository. We present a novel framework…

Methodology · Statistics 2021-06-02 Thanh Vinh Vo , Trong Nghia Hoang , Young Lee , Tze-Yun Leong

In causal inference, it is common to estimate the causal effect of a single treatment variable on an outcome. However, practitioners may also be interested in the effect of simultaneous interventions on multiple covariates of a fixed target…

Methodology · Statistics 2022-11-24 Jaime Roquero Gimenez , Dominik Rothenhäusler

With the evolution of single-cell RNA sequencing techniques into a standard approach in genomics, it has become possible to conduct cohort-level causal inferences based on single-cell-level measurements. However, the individual gene…

Methodology · Statistics 2025-04-23 Jin-Hong Du , Zhenghao Zeng , Edward H. Kennedy , Larry Wasserman , Kathryn Roeder

Research on causal effects often relies on synthetic data due to the scarcity of real-world datasets with ground-truth effects. Since current data-generating tools do not always meet all requirements for state-of-the-art research, ad-hoc…

Artificial Intelligence · Computer Science 2024-05-24 Andreas W M Sauter , Erman Acar , Aske Plaat

The recent availability of huge, many-dimensional data sets, like those arising from genome-wide association studies (GWAS), provides many opportunities for strengthening causal inference. One popular approach is to utilize these…

Machine Learning · Statistics 2020-12-21 Ioan Gabriel Bucur , Tom Claassen , Tom Heskes