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Digital twins are emerging as a valuable tool for short-term decision-making as well as for long-term strategic planning across numerous domains, including process industry, energy, space, transport, and healthcare. This paper reports on…

Artificial Intelligence · Computer Science 2025-05-13 Riccardo Sieve , Paul Kobialka , Laura Slaughter , Rudolf Schlatte , Einar Broch Johnsen , Silvia Lizeth Tapia Tarifa

We propose a digital twin approach to improve healthcare decision support systems with a combination of domain knowledge and data. Domain knowledge helps build decision thresholds that doctors can use to determine a risk or recommend a…

Artificial Intelligence · Computer Science 2019-10-31 Dattaraj Jagdish Rao , Shraddha Mane

We introduce a novel methodology that leverages the strength of Physics-Informed Neural Networks (PINNs) to address the counterdiabatic (CD) protocol in the optimization of quantum circuits comprised of systems with $N_{Q}$ qubits. The…

Chronic diseases constitute the principal burden of morbidity, mortality, and healthcare costs worldwide, yet current health systems remain fragmented and predominantly reactive. Patient Medical Digital Twins (PMDTs) offer a paradigm shift:…

Software Engineering · Computer Science 2026-02-13 Micheal P. Papazoglou , Bernd J. Krämer , Mira Raheem , Amal Elgammal

Recently, significant efforts have been made to create Health Digital Twins (HDTs), digital twins for clinical applications. Heart modeling is one of the fastest-growing fields, which favors the effective application of HDTs. The clinical…

Neurons and Cognition · Quantitative Biology 2024-03-21 Zofia Rudnicka , Klaudia Proniewska , Mark Perkins , Agnieszka Pregowska

Colorectal cancer, inflammatory bowel disease, and diverticular disease are progressive conditions that affect millions of individuals worldwide and impose substantial clinical and economic burdens. Early detection and personalized…

Emerging Technologies · Computer Science 2026-03-20 Sayed Chhattan Shah , Andrea Townsend-Nicholson , Spiros Denaxas , Pablo Lamata , Manish Chand

Purpose: MicroWave Ablation (MWA) modeling and simulation bear great potential for loco-regional treatment of liver tumors. However, accurately positioning the antenna according to a planned orientation/location is technically challenging.…

Medical Physics · Physics 2026-05-26 Ilias Nahmed , Francesco Dettori , Juan Verde , Michel Duprez , Pablo Alvarez , Stéphane Cotin

Background and Objective: Precise preoperative planning and effective physician training for coronary interventions are increasingly important. Despite advances in medical imaging technologies, transforming static or limited dynamic imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Shuo Wang , Tong Ren , Nan Cheng , Rong Wang , Li Zhang

Digital twins (DTs) are revolutionizing the biotechnology industry by enabling sophisticated digital representations of biological assets, microorganisms, drug development processes, and digital health applications. However, digital…

Machine Learning · Computer Science 2024-02-02 Mohammad , Jamshidi , Dinh Thai Hoang , Diep N. Nguyen

Digital Twin (DT) technology holds immense potential for surgical planning and personalized medicine. However, generating interactive, patient-specific anatomical twins currently relies on computationally heavy Server-Side Rendering (SSR)…

Graphics · Computer Science 2026-05-20 Oserebameh Augustine Beckley

Quantifying hemodynamics in the curved segments of the intracranial internal carotid artery is a core challenge in diagnosing vascular stenosis. Conventional full-field imaging, such as 4D Flow MRI, is costly and difficult to widely…

Medical Physics · Physics 2026-05-14 Jingtai Song , Qinsheng Zhu , Xiaodong Xing , Yufeng Tang , Zhiyun Zhang , Xianwen Zhang , Hao Wu

Radiotherapy planning is a critical aspect of cancer treatment, where the optimal selection of beam directions and dose distributions significantly impacts treatment efficacy and patient outcomes. Traditionally, this process involves…

Medical Physics · Physics 2023-12-05 Keshav Kumar K. , NVSL Narasimham , A. Ramakrishna Prasad

A cardiac digital twin is a virtual replica of a patient's heart for screening, diagnosis, prognosis, risk assessment, and treatment planning of cardiovascular diseases. This requires an anatomically accurate patient-specific 3D structural…

The development of a digital twin (DT) framework for fast online adaptive proton therapy planning in prostate stereotactic body radiation therapy (SBRT) with dominant intraprostatic lesion (DIL) boost represents a significant advancement in…

Objective: Modern medicine needs to shift from a wait and react, curative discipline to a preventative, interdisciplinary science aiming at providing personalised, systemic and precise treatment plans to patients. The aim of this work is to…

Machine Learning · Statistics 2020-09-18 Pietro Barbiero , Ramon Viñas Torné , Pietro Lió

Recent technological advances have expanded the availability of high-throughput biological datasets, enabling the reliable design of digital twins of biomedical systems or patients. Such computational tools represent key reaction networks…

Quantitative Methods · Quantitative Biology 2025-09-03 Clémence Métayer , Annabelle Ballesta , Julien Martinelli

A digital twin is a virtual replica of a real-world physical phenomena that uses mathematical modeling to characterize and simulate its defining features. By constructing digital twins for disease processes, we can perform in-silico…

Machine Learning · Computer Science 2024-11-04 Keying Kuang , Frances Dean , Jack B. Jedlicki , David Ouyang , Anthony Philippakis , David Sontag , Ahmed M. Alaa

The application of Digital Twin (DT) technology and Federated Learning (FL) has great potential to change the field of biomedical image analysis, particularly for Computed Tomography (CT) scans. This paper presents Federated Transfer…

Image and Video Processing · Electrical Eng. & Systems 2025-09-11 Avais Jan , Qasim Zia , Murray Patterson

The concept of creating a virtual copy of a complete Cyber-Physical System opens up numerous possibilities, including real-time assessments of the physical environment and continuous learning from the system to provide reliable and precise…

Artificial Intelligence · Computer Science 2023-11-22 Carine Menezes Rebello , Johannes Jäschkea , Idelfonso B. R. Nogueira

Objective: Clinical implementation of deformable image registration (DIR) requires voxel-based spatial accuracy metrics such as manually identified landmarks, which are challenging to implement for highly mobile gastrointestinal (GI)…