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The effective localization of mitosis is a critical precursory task for deciding tumor prognosis and grade. Automated mitosis detection through deep learning-oriented image analysis often fails on unseen patient data due to inherent domain…
Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in…
Identification and counting of cells and mitotic figures is a standard task in diagnostic histopathology. Due to the large overall cell count on histological slides and the potential sparse prevalence of some relevant cell types or mitotic…
Mitosis detection is one of the fundamental tasks in computational pathology, which is extremely challenging due to the heterogeneity of mitotic cell. Most of the current studies solve the heterogeneity in the technical aspect by increasing…
MIDOG 2025 Track 1 requires mitosis detection in whole-slideimages (WSIs) containing non-tumor, inflamed, and necrotic re-gions. Due to the complicated and heterogeneous context, aswell as possible artifacts, there are often false positives…
This work presents a mitosis detection method with only one vanilla Convolutional Neural Network (CNN). Our method consists of two steps: given an image, we first apply a CNN using a sliding window technique to extract patches that have…
The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis…
Mitotic figures represent a key histoprognostic feature in tumor pathology, providing crucial insights into tumor aggressiveness and proliferation. However, their identification remains challenging, subject to significant inter-observer…
Mitotic activity is a crucial proliferation biomarker for the diagnosis and prognosis of different types of cancers. Nevertheless, mitosis counting is a cumbersome process for pathologists, prone to low reproducibility, due to the large…
For the MIDOG mitosis detection challenge, we created a cascade algorithm consisting of a Mask-RCNN detector, followed by a classification ensemble consisting of ResNet50 and DenseNet201 to refine detected mitotic candidates. The MIDOG…
In certain types of cancerous tissue, mitotic count has been shown to be associated with tumor proliferation, poor prognosis, and therapeutic resistance. Due to the high inter-rater variability of mitotic counting by pathologists,…
This paper describes our contribution to the MIDOG 2022 challenge for detecting mitotic cells. One of the major problems to be addressed in the MIDOG 2022 challenge is the robustness under the natural variance that appears for real-life…
Atypical mitotic figures (AMFs) are important histopathological markers yet remain challenging to identify consistently, particularly under domain shift stemming from scanner, stain, and acquisition differences. We present a simple…
This paper presents our solution for the MIDOG 2025 Challenge Track 2, which focuses on binary classification of normal mitotic figures (NMFs) versus atypical mitotic figures (AMFs) in histopathological images. Our approach leverages a…
Each woman living in the United States has about 1 in 8 chance of developing invasive breast cancer. The mitotic cell count is one of the most common tests to assess the aggressiveness or grade of breast cancer. In this prognosis,…
Domain variability is a common bottle neck in developing generalisable algorithms for various medical applications. Motivated by the observation that the domain variability of the medical images is to some extent compact, we propose to…
Atypical mitotic figures are important biomarkers of tumor aggressiveness in histopathology, yet reliable recognition remains challenging due to severe class imbalance and variability across imaging domains. We present a DenseNet-121-based…
Breast cancer is the most commonly diagnosed cancer worldwide, with over two million new cases each year. During diagnostic tumour grading, pathologists manually count the number of dividing cells (mitotic figures) in biopsy or tumour…
Mitotic figures are classified into typical and atypical variants, with atypical counts correlating strongly with tumor aggressiveness. Accurate differentiation is therefore essential for patient prognostication and resource allocation, yet…
The account of mitotic cells is a key feature in tumor diagnosis. However, due to the variability of mitotic cell morphology, it is a highly challenging task to detect mitotic cells in tumor tissues. At the same time, although advanced deep…