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Cardiac arrhythmogenesis is governed by complex electromechanical interactions that are not directly observable in vivo, motivating the development of non-invasive computational approaches for reconstructing three-dimensional activation…

Medical Physics · Physics 2026-03-05 Nathan Dermul , Hans Dierckx

Simulation of post-prandial pharmacokinetics, such as muscle protein synthesis (MPS) through mTORC1 and insulin-induced glucose uptake, is often challenging due to the computational intensity of the multi-compartmental approach. In this…

Other Quantitative Biology · Quantitative Biology 2026-05-28 Alberto Calderone

We present a high-fidelity three dimensional computational framework for simulating the bulk mechanical behavior of granular aggregates composed of deformable brittle grains. Departing from classical discrete element methods (DEM), our…

Soft Condensed Matter · Physics 2025-07-16 Debdeep Bhattacharya , Davood Damircheli , Robert P. Lipton

Magnetic Resonance Elastography allows noninvasive visualization of tissue mechanical properties by measuring the displacements resulting from applied stresses, and fitting a mechanical model. Poroelasticity naturally lends itself to…

Modeling of respiratory motion is important for a more accurate understanding and accounting of its effect on dose to cancers in the thorax and abdomen by radiotherapy. We have developed a model of respiration-induced organ motion in the…

We describe a mathematical modeling of the digestion in the small intestine. The main interest of our work is to consider, at the same time, different aspects of the digestion i.e. the transport of the bolus all along the intestine,…

Dynamical Systems · Mathematics 2011-11-22 Masoomeh Taghipoor , Philippe Lescoat , Christine Georgelin , Jean-René Licois , Guy Barles

Robotic devices hold great potential for efficient and reliable assessment of neuromotor abnormalities in post-stroke patients. However, spasticity caused by stroke is still assessed manually in clinical settings. The limited and variable…

Robotics · Computer Science 2024-12-09 Hao Yu , Zebin Huang , Yutong Li , Xinliang Guo , Vincent Crocher , Ignacio Carlucho , Mustafa Suphi Erden

Laparoscopy is an electrosurgical medical operation often involving an application of high-frequency alternating current to remove undesired biological tissue from the insufflated abdomen accessible through inlet and outlets trocars. One of…

This study demonstrates that the soft biological tissues of humans can be used as a type of soft body in physical reservoir computing. Soft biological tissues possess characteristics such as stress-strain nonlinearity and viscoelasticity…

Neurons and Cognition · Quantitative Biology 2025-09-22 Yo Kobayashi

The pathogenesis of esophageal disorders is related to the esophageal wall mechanics. Therefore, to understand the underlying fundamental mechanisms behind various esophageal disorders, it is crucial to map the esophageal wall…

The human heart is enclosed in the pericardial cavity. The pericardium consists of a layered thin sac and is separated from the myocardium by a thin film of fluid. It provides a fixture in space and frictionless sliding of the myocardium.…

Computational Engineering, Finance, and Science · Computer Science 2018-12-11 Martin R. Pfaller , Julia M. Hörmann , Martina Weigl , Andreas Nagler , Radomir Chabiniok , Cristóbal Bertoglio , Wolfgang A. Wall

The field of cardiac electrophysiology tries to abstract, describe and finally model the electrical characteristics of a heartbeat. With recent advances in cardiac electrophysiology, models have become more powerful and descriptive as ever.…

Medical Physics · Physics 2022-12-16 Thomas Grandits , Simone Pezzuto , Gernot Plank

We propose an integrated electromechanical model of the human heart, with focus on the left ventricle, wherein biophysically detailed models describe the different physical phenomena concurring to the cardiac function. We model the…

Computer models of humans are ubiquitous throughout computer animation and computer vision. However, these models rarely represent the dynamics of human motion, as this requires adding a complex layer that solves body motion in response to…

Graphics · Computer Science 2023-10-30 Pablo Ramón , Cristian Romero , Javier Tapia , Miguel A. Otaduy

Fluoroscopy is a radiographic procedure for evaluating esophageal disorders such as achalasia, dysphasia and gastroesophageal reflux disease (GERD). It performs dynamic imaging of the swallowing process and provides anatomical detail and a…

Fluid mechanical peristaltic transport through esophagus has been of concern in the paper. A mathematical model has been developed with an aim to study the peristaltic transport of a rheological fluid for arbitrary wave shapes and tube…

Fluid Dynamics · Physics 2012-12-17 J. C. Misra , S. Maiti

When generating in-silico clinical electrophysiological outputs, such as electrocardiograms (ECGs) and body surface potential maps (BSPMs), mathematical models have relied on single physics, i.e. of the cardiac electrophysiology (EP),…

Numerical Analysis · Mathematics 2024-02-12 Elena Zappon , Matteo Salvador , Roberto Piersanti , Francesco Regazzoni , Luca Dede' , Alfio Quarteroni

A new model is suggested and used to mimic various spatial or temporal designs in biological or non biological formations where the focus is on the normal or irregular electrical signals coming from human heart (ECG) or brain (EEG). The…

Biological Physics · Physics 2008-07-08 Caglar Tuncay

The ability of mechanical systems to perform basic computations has gained traction over recent years, providing an unconventional alternative to digital computing in off grid, low power, and severe environments which render the majority of…

Applied Physics · Physics 2024-05-13 M. Moghaddaszadeh , M. Mousa , A. Aref , M. Nouh

Eating monitoring has remained an open challenge in medical research for years due to the lack of non-invasive sensors for continuous monitoring and the reliable methods for automatic behavior detection. In this paper, we present a pilot…

Machine Learning · Computer Science 2025-02-21 Xu-Lu Zhang , Zhen-Qun Yang , Dong-Mei Jiang , Ga Liao , Qing Li , Ramesh Jain , Xiao-Yong Wei