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Imaging in thick biological tissues is often degraded by sample-induced aberrations, which reduce image quality and resolution, particularly in super-resolution techniques. While hardware-based adaptive optics, which correct aberrations…
The remarkable performance of large multimodal models (LMMs) has attracted significant interest from the image segmentation community. To align with the next-token-prediction paradigm, current LMM-driven segmentation methods either use…
Automatic segmentation of the prostate cancer from the multi-modal magnetic resonance images is of critical importance for the initial staging and prognosis of patients. However, how to use the multi-modal image features more efficiently is…
Non-point spatial objects (e.g., polygons, linestrings, etc.) are ubiquitous. We study the problem of indexing non-point objects in memory for range queries and spatial intersection joins. We propose a secondary partitioning technique for…
A single biomedical image can be meaningfully segmented in multiple ways, depending on the desired application. For instance, a brain MRI can be segmented according to tissue types, vascular territories, broad anatomical regions,…
Structural magnetic resonance imaging (MRI) has been widely utilized for analysis and diagnosis of brain diseases. Automatic segmentation of brain tumors is a challenging task for computer-aided diagnosis due to low-tissue contrast in the…
Mohs micrographic surgery (MMS) is the gold standard technique for removing high risk nonmelanoma skin cancer however, intraoperative histopathological examination demands significant time, effort, and professionality. The objective of this…
Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…
Tissue semantic segmentation is one of the key tasks in computational pathology. To avoid the expensive and laborious acquisition of pixel-level annotations, a wide range of studies attempt to adopt the class activation map (CAM), a…
We propose a novel method for multiple clustering that assumes a co-clustering structure (partitions in both rows and columns of the data matrix) in each view. The new method is applicable to high-dimensional data. It is based on a…
Advances in cellular imaging technologies, especially those based on fluorescence in situ hybridization (FISH) now allow detailed visualization of the spatial organization of human or bacterial cells. Quantifying this spatial organization…
High dimensional categorical data are routinely collected in biomedical and social sciences. It is of great importance to build interpretable parsimonious models that perform dimension reduction and uncover meaningful latent structures from…
Mass abnormality segmentation is a vital step for the medical diagnostic process and is attracting more and more the interest of many research groups. Currently, most of the works achieved in this area have used the Gray Level Co-occurrence…
Segmentation is essential for medical image analysis to identify and localize diseases, monitor morphological changes, and extract discriminative features for further diagnosis. Skin cancer is one of the most common types of cancer…
Bayesian model selection provides a powerful framework for objectively comparing models directly from observed data, without reference to ground truth data. However, Bayesian model selection requires the computation of the marginal…
Phyllodes tumors (PTs) are rare fibroepithelial breast lesions that are difficult to classify preoperatively due to their radiological similarity to benign fibroadenomas. This often leads to unnecessary surgical excisions. To address this,…
Although deep neural networks have been a dominant method for many 2D vision tasks, it is still challenging to apply them to 3D tasks, such as medical image segmentation, due to the limited amount of annotated 3D data and limited…
Efficient and accurate multi-organ segmentation from abdominal CT volumes is a fundamental challenge in medical image analysis. Existing 3D segmentation approaches are computationally and memory intensive, often processing entire volumes…
Computer-assisted quantitative analysis on Giga-pixel pathology images has provided a new avenue in histology examination. The innovations have been largely focused on cancer pathology (i.e., tumor segmentation and characterization). In…
Coulomb explosion imaging (CEI) is a powerful technique for capturing the real-time motion of individual atoms during ultrafast photochemical reactions. CEI generates high-dimensional data with naturally embedded correlations that allow…