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Inspection of tissues using a light microscope is the primary method of diagnosing many diseases, notably cancer. Highly multiplexed tissue imaging builds on this foundation, enabling the collection of up to 60 channels of molecular…

Digital pathology and microscopy image analysis are widely employed in the segmentation of digitally scanned IHC slides, primarily to identify cancer and pinpoint regions of interest (ROI) indicative of tumor presence. However, current ROI…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Akash Modi , Sumit Kumar Jha , Purnendu Mishra , Rajiv Kumar , Kiran Aatre , Gursewak Singh , Shubham Mathur

This paper addresses the problem of liver cancer segmentation in Whole Slide Image (WSI). We propose a multi-scale image processing method based on automatic end-to-end deep neural network algorithm for segmentation of cancer area. A…

Image and Video Processing · Electrical Eng. & Systems 2020-07-29 Yanbo Feng , Adel Hafiane , Hélène Laurent

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Point-level Supervised Instance Segmentation (PSIS) aims to enhance the applicability and scalability of instance segmentation by utilizing low-cost yet instance-informative annotations. Existing PSIS methods usually rely on positional…

Computer Vision and Pattern Recognition · Computer Science 2024-01-19 Zipeng Wang , Xuehui Yu , Xumeng Han , Wenwen Yu , Zhixun Huang , Jianbin Jiao , Zhenjun Han

In biomedical imaging reliable segmentation of objects (e.g. from small cells up to large organs) is of fundamental importance for automated medical diagnosis. New approaches for multi-scale segmentation can considerably improve performance…

Numerical Analysis · Mathematics 2016-10-04 Leonie Zeune , Guus van Dalum , Leon W. M. M. Terstappen , S. A. van Gils , Christoph Brune

Healthcare applications are inherently multimodal, benefiting greatly from the integration of diverse data sources. However, the modalities available in clinical settings can vary across different locations and patients. A key area that…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Mohammed Amer , Mohamed A. Suliman , Tu Bui , Nuria Garcia , Serban Georgescu

Shape modelling (with methods that output shapes) is a new and important task in Bayesian nonparametrics and bioinformatics. In this work, we focus on Bayesian nonparametric methods for capturing shapes by partitioning a space using curves.…

Machine Learning · Statistics 2022-11-08 Shufei Ge , Shijia Wang , Lloyd Elliott

Nanophotonic devices excel at confining light into intense hot spots of the electromagnetic near fields, creating unprecedented opportunities for light-matter coupling and surface-enhanced sensing. Recently, all-dielectric metasurfaces with…

We present a new instance segmentation approach tailored to biological images, where instances may correspond to individual cells, organisms or plant parts. Unlike instance segmentation for user photographs or road scenes, in biological…

Computer Vision and Pattern Recognition · Computer Science 2020-04-24 Victor Kulikov , Victor Lempitsky

Mammography is the primary imaging modality used for early detection and diagnosis of breast cancer. X-ray mammogram analysis mainly refers to the localization of suspicious regions of interest followed by segmentation, towards further…

Image and Video Processing · Electrical Eng. & Systems 2020-12-09 Yutong Yan , Pierre-Henri Conze , Gwenolé Quellec , Mathieu Lamard , Béatrice Cochener , Gouenou Coatrieux

Image analysis using more than one modality (i.e. multi-modal) has been increasingly applied in the field of biomedical imaging. One of the challenges in performing the multimodal analysis is that there exist multiple schemes for fusing the…

Computer Vision and Pattern Recognition · Computer Science 2018-06-19 Zhe Guo , Xiang Li , Heng Huang , Ning Guo , Quanzheng Li

Polyp segmentation for colonoscopy images is of vital importance in clinical practice. It can provide valuable information for colorectal cancer diagnosis and surgery. While existing methods have achieved relatively good performance, polyp…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Xiaolu Kang , Zhuoqi Ma , Kang Liu , Yunan Li , Qiguang Miao

The scarcity of labeled data often impedes the application of deep learning to the segmentation of medical images. Semi-supervised learning seeks to overcome this limitation by exploiting unlabeled examples in the learning process. In this…

Computer Vision and Pattern Recognition · Computer Science 2021-06-25 Jizong Peng , Marco Pedersoli , Christian Desrosiers

Spatial transcriptomics has revolutionized tissue analysis by simultaneously mapping gene expression, spatial topography, and histological context across consecutive tissue sections, enabling systematic investigation of spatial…

Applications · Statistics 2025-10-24 Meng Zhou , Shuangge Ma , Mengyun Wu

Nuclear segmentation and classification within Haematoxylin & Eosin stained histology images is a fundamental prerequisite in the digital pathology work-flow. The development of automated methods for nuclear segmentation and classification…

Computer Vision and Pattern Recognition · Computer Science 2019-11-14 Simon Graham , Quoc Dang Vu , Shan E Ahmed Raza , Ayesha Azam , Yee Wah Tsang , Jin Tae Kwak , Nasir Rajpoot

Diffusion magnetic resonance imaging (dMRI) provides a unique tool for noninvasively probing the microstructure of the neuronal tissue. The NODDI model has been a popular approach to the estimation of tissue microstructure in many…

Computer Vision and Pattern Recognition · Computer Science 2017-04-06 Chuyang Ye

Instance segmentation of overlapping objects in biomedical images remains a largely unsolved problem. We take up this challenge and present MultiStar, an extension to the popular instance segmentation method StarDist. The key novelty of our…

Computer Vision and Pattern Recognition · Computer Science 2021-01-15 Florin C. Walter , Sebastian Damrich , Fred A. Hamprecht

Human pose estimation, a vital task in computer vision, involves detecting and localising human joints in images and videos. While single-frame pose estimation has seen significant progress, it often fails to capture the temporal dynamics…

Computer Vision and Pattern Recognition · Computer Science 2025-01-27 Cesare Davide Pace , Alessandro Marco De Nunzio , Claudio De Stefano , Francesco Fontanella , Mario Molinara

The task of automatically segmenting 3-D surfaces representing boundaries of objects is important for quantitative analysis of volumetric images, and plays a vital role in biomedical image analysis. Recently, graph-based methods with a…

Computer Vision and Pattern Recognition · Computer Science 2018-01-10 Abhay Shah , Michael Abramoff , Xiaodong Wu