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Spatial transcriptomics (ST) technologies have revolutionized the study of gene expression patterns in tissues by providing multimodality data in transcriptomic, spatial, and morphological, offering opportunities for understanding tissue…

Computational Engineering, Finance, and Science · Computer Science 2024-01-17 Zelin Zang , Liangyu Li , Yongjie Xu , Chenrui Duan , Kai Wang , Yang You , Yi Sun , Stan Z. Li

Score-based Generative Models (SGMs) have demonstrated exceptional synthesis outcomes across various tasks. However, the current design landscape of the forward diffusion process remains largely untapped and often relies on physical…

Machine Learning · Computer Science 2023-10-13 Kushagra Pandey , Stephan Mandt

In this study, we focus on the unsupervised domain adaptation problem where an approximate inference model is to be learned from a labeled data domain and expected to generalize well to an unlabeled data domain. The success of unsupervised…

Computer Vision and Pattern Recognition · Computer Science 2020-08-11 Jing Wang , Jiahong Chen , Jianzhe Lin , Leonid Sigal , Clarence W. de Silva

Spatial transcriptomics (ST) profiles gene expression across a tissue section while preserving the spatial coordinates. Because current ST technologies typically profile two-dimensional tissue slices, integrating and aligning slices from…

Quantitative Methods · Quantitative Biology 2026-03-20 Yaqi Wu , Jingfeng Wang , Xin Maizie Zhou , Yanxiang Zhao , Zixuan Cang

While latent diffusion models (LDMs), such as Stable Diffusion, are designed for high-resolution (HR) image generation, they often struggle with significant structural distortions when generating images at resolutions higher than their…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Boyuan Cao , Jiaxin Ye , Yujie Wei , Hongming Shan

The Diffusion Transformer (DiT) architecture is the state-of-the-art paradigm for high-fidelity image generation, underpinning models like Stable Diffusion-3 and FLUX.1. However, deploying these models on resource-constrained mobile devices…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Kunpeng Du , Haizhen Xie , Sen Lu , Lei Yu , Binglei Bao , Huaao Tang , Chuntao Liu , Hao Wu , Yang Zhao , Zhicai Huang , Heyuan Gao , Zhijun Tu , Jie Hu , Xinghao Chen

Spatial transcriptomics (ST) is a novel technique that simultaneously captures pathological images and gene expression profiling with spatial coordinates. Since ST is closely related to pathological features such as disease subtypes, it may…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Kazuya Nishimura , Ryoma Bise , Yasuhiro Kojima

The advancement of Spatial Transcriptomics (ST) has facilitated the spatially-aware profiling of gene expressions based on histopathology images. Although ST data offers valuable insights into the micro-environment of tumors, its…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Hongyi Wang , Xiuju Du , Jing Liu , Shuyi Ouyang , Yen-Wei Chen , Lanfen Lin

Tokenizers are a key component of state-of-the-art generative image models, extracting the most important features from the signal while reducing data dimension and redundancy. Most current tokenizers are based on KL-regularized variational…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Théophane Vallaeys , Jakob Verbeek , Matthieu Cord

Spatial transcriptomics is a technology that captures gene expression levels at different spatial locations, widely used in tumor microenvironment analysis and molecular profiling of histopathology, providing valuable insights into…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Junzhuo Liu , Markus Eckstein , Zhixiang Wang , Friedrich Feuerhake , Dorit Merhof

High-resolution (HR) MRI scans obtained from research-grade medical centers provide precise information about imaged tissues. However, routine clinical MRI scans are typically in low-resolution (LR) and vary greatly in contrast and spatial…

Image and Video Processing · Electrical Eng. & Systems 2023-08-25 Jueqi Wang , Jacob Levman , Walter Hugo Lopez Pinaya , Petru-Daniel Tudosiu , M. Jorge Cardoso , Razvan Marinescu

Local SGD is a promising approach to overcome the communication overhead in distributed learning by reducing the synchronization frequency among worker nodes. Despite the recent theoretical advances of local SGD in empirical risk…

Machine Learning · Computer Science 2021-03-01 Yuyang Deng , Mehrdad Mahdavi

Spatial transcriptomics aims to connect high-resolution histology images with spatially resolved gene expression. To achieve better performance on downstream tasks such as gene expression prediction, large-scale pre-training is required to…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Jiahe Qian , Yaoyu Fang , Ziqiao Weng , Xinkun Wang , Lee A. Cooper , Bo Zhou

Large-scale generative models have achieved remarkable advancements in various visual tasks, yet their application to shadow removal in images remains challenging. These models often generate diverse, realistic details without adequate…

Computer Vision and Pattern Recognition · Computer Science 2024-12-04 Xinjie Li , Yang Zhao , Dong Wang , Yuan Chen , Li Cao , Xiaoping Liu

Since the training data of the target model is not available in the black-box substitute attack, most recent schemes utilize GANs to generate data for training the substitute model. However, these GANs-based schemes suffer from low training…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Mingwen Shao , Lingzhuang Meng , Yuanjian Qiao , Lixu Zhang , Wangmeng Zuo

We present LongCat-AudioDiT, a novel, non-autoregressive diffusion-based text-to-speech (TTS) model that achieves state-of-the-art (SOTA) performance. Unlike previous methods that rely on intermediate acoustic representations such as…

Sound · Computer Science 2026-04-01 Detai Xin , Shujie Hu , Chengzuo Yang , Chen Huang , Guoqiao Yu , Guanglu Wan , Xunliang Cai

The spatial context of single-cell gene expression data is crucial for many downstream analyses, yet often remains inaccessible due to practical and technical limitations, restricting the utility of such datasets. In this paper, we propose…

Machine Learning · Computer Science 2025-11-21 Wenbin Zhou , Jin-Hong Du

Despite their success, Segment Anything Models (SAMs) experience significant performance drops on severely degraded, low-quality images, limiting their effectiveness in real-world scenarios. To address this, we propose GleSAM, which…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Guangqian Guo , Yong Guo , Xuehui Yu , Wenbo Li , Yaoxing Wang , Shan Gao

Generative diffusion models have achieved remarkable success in producing high-quality images. However, these models typically operate in continuous intensity spaces, diffusing independently across pixels and color channels. As a result,…

Graphics · Computer Science 2025-05-20 Javier E. Santos , Agnese Marcato , Roman Colman , Nicholas Lubbers , Yen Ting Lin

While perspective is a well-studied topic in art, it is generally taken for granted in images. However, for the recent wave of high-quality image synthesis methods such as latent diffusion models, perspective accuracy is not an explicit…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Rishi Upadhyay , Howard Zhang , Yunhao Ba , Ethan Yang , Blake Gella , Sicheng Jiang , Alex Wong , Achuta Kadambi