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There is a pressing need to better understand how microbial populations respond to antimicrobial drugs, and to find mechanisms to possibly eradicate antimicrobial-resistant cells. The inactivation of antimicrobials by resistant microbes can…

Populations and Evolution · Quantitative Biology 2023-11-16 Lluís Hernández-Navarro , Matthew Asker , Alastair M. Rucklidge , Mauro Mobilia

Statistical physics can describe the behavior of microbial populations consisting of many heterogeneous individuals. A direct consequence is the existence of phase transitions, where the behavior of a population changes discontinuously upon…

Populations and Evolution · Quantitative Biology 2026-04-20 Kaan Öcal , Syrine Ghrabli , Michael P. H. Stumpf

Microbial communities routinely have several possible species compositions or community states observed for the same environmental parameters. Changes in these parameters can trigger abrupt and persistent transitions (regime shifts) between…

Populations and Evolution · Quantitative Biology 2019-07-03 Veronika Dubinkina , Yulia Fridman , Parth Pratim Pandey , Sergei Maslov

In a wide variety of natural systems, closely-related microbial strains coexist stably, resulting in high levels of fine-scale biodiversity. However, the mechanisms that stabilize this coexistence are not fully understood. Spatial…

Populations and Evolution · Quantitative Biology 2023-03-29 Casey Barkan , Shenshen Wang

The dynamics of many microbial ecosystems are driven by cross-feeding interactions, in which metabolites excreted by some species are metabolised further by others. The population dynamics of such ecosystems are governed by…

Populations and Evolution · Quantitative Biology 2016-08-16 Björn Vessman , Philip Gerlee , Torbjörn Lundh

Clonal microbes can switch between different phenotypes and recent theoretical work has shown that stochastic switching between these subpopulations can stabilize microbial communities. This phenotypic switching need not be stochastic,…

Populations and Evolution · Quantitative Biology 2025-12-12 Pierre A. Haas , Maria A. Gutierrez , Nuno M. Oliveira , Raymond E. Goldstein

Resource are often not uniformly distributed within a population. Spatial variations of concentration of a resource, change the fitness of competing strategies locally. The notion of fitness varying with respect to both genotype and…

Populations and Evolution · Quantitative Biology 2022-04-08 Hossein Nemati , Mohammad Reza Ejtehadi , Kamran Kaveh

In apparent contradiction to competition theory, the number of known, co-existing plankton species far exceeds their explicable biodiversity - a discrepancy termed the Paradox of the Plankton. We introduce a new game-theoretic model for…

Populations and Evolution · Quantitative Biology 2020-12-14 Susanne Menden-Deuer , Julie Rowlett

Heterogeneous systems of active matter exhibit a range of complex emergent dynamical patterns. In particular, it is difficult to predict the properties of the mixed system based on its constituents. These considerations are particularly…

Soft Condensed Matter · Physics 2021-04-07 Shlomit Peled , Shawn D. Ryan , Sebastian Heidenreich , Markus Bar , Gil Ariel , Avraham Be'er

Microbial ecosystems are commonly modeled by fixed interactions between species in steady exponential growth states. However, microbes often modify their environments so strongly that they are forced out of the exponential state into…

Populations and Evolution · Quantitative Biology 2024-01-08 Avaneesh V. Narla , Terence Hwa , Arvind Murugan

Microbes providing public goods are widespread in nature despite running the risk of being exploited by free-riders. However, the precise ecological factors supporting cooperation are still puzzling. Following recent experiments, we…

Populations and Evolution · Quantitative Biology 2012-03-28 Jonas Cremer , Anna Melbinger , Erwin Frey

Species-rich communities, such as the microbiota or microbial ecosystems, provide key functions for human health and climatic resilience. Increasing effort is being dedicated to design experimental protocols for selecting community-level…

Populations and Evolution · Quantitative Biology 2023-06-22 Jules Fraboul , Giulio Biroli , Silvia De Monte

In the last years, a remarkable theoretical effort has been made in order to understand stability and complexity in ecological communities. The non-random structures of real ecological interaction networks has been recognized as one key…

Populations and Evolution · Quantitative Biology 2013-01-09 Samir Suweis , Jacopo Grilli , Amos Maritan

Spatial structure and species interactions jointly shape the dynamics and biodiversity of ecological systems, yet most theoretical models either neglect spatial heterogeneity or sacrifice analytical tractability. Here, we provide a unified…

Populations and Evolution · Quantitative Biology 2026-05-08 Davide Bernardi , Alice Doimo , Giorgio Nicoletti , Prajwal Padmanabha , Andrea Rinaldo , Samir Suweis , Sandro Azaele , Amos Maritan

How large ecosystems can create and maintain the remarkable biodiversity we see in nature is probably one of the biggest open questions in science, attracting attention from different fields, from Theoretical Ecology to Mathematics and…

Populations and Evolution · Quantitative Biology 2023-01-03 Violeta Calleja-Solanas , Nagi Khalil , Jesús Gómez-Gardeñes , Emilio Hernández-García , Sandro Meloni

Bacteria possess diverse mechanisms to regulate their motility in response to environmental and physiological signals, enabling them to navigate complex habitats and adapt their behavior. Among these mechanisms, interspecies recognition…

Populations and Evolution · Quantitative Biology 2025-12-01 Mattia Mattei , David Soriano Paños , Mahantesh Halappanavar , Alex Arenas

Coexistence of individuals with different species or phenotypes is often found in nature in spite of competition between them. Stable coexistence of multiple types of individuals have implications for maintenance of ecological biodiversity…

Disordered Systems and Neural Networks · Physics 2007-05-23 Naoki Masuda , Norio Konno

Classic computational models of collective motion suggest that simple local averaging rules can promote many observed group level patterns. Recent studies, however, suggest that rules simpler than local averaging may be at play in real…

Adaptation and Self-Organizing Systems · Physics 2022-05-19 Vivek Jadhav , Vishwesha Guttal , Danny Raj M

During the last decades macroecology has identified broad-scale patterns of abundances and diversity of microbial communities and put forward some potential explanations for them. However, these advances are not paralleled by a full…

Populations and Evolution · Quantitative Biology 2024-01-26 José Camacho-Mateu , Aniello Lampo , Matteo Sireci , Miguel Ángel Muñoz , José A. Cuesta

A key question in biological systems is whether genetic diversity persists in the long run under evolutionary competition or whether a single dominant genotype emerges. Classic work by Kalmus in 1945 has established that even in simple…

Populations and Evolution · Quantitative Biology 2015-10-23 Ruta Mehta , Ioannis Panageas , Georgios Piliouras , Sadra Yazdanbod