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This study introduces a novel computational framework for Robust Topology Optimization (RTO) considering imprecise random field parameters. Unlike the worst-case approach, the present method provides upper and lower bounds for the mean and…

Computational Engineering, Finance, and Science · Computer Science 2022-01-28 Kang Gao , Duy Minh Doc , Sheng Chu , Gang Wu , H. Alicia Kim , Carol A. Featherston

One of the challenges practitioners face when applying structure learning algorithms to their data involves determining a set of hyperparameters; otherwise, a set of hyperparameter defaults is assumed. The optimal hyperparameter…

Machine Learning · Computer Science 2023-06-27 Kiattikun Chobtham , Anthony C. Constantinou

The comparison of protein structures is a fundamental task in computational biology, crucial for understanding protein function, evolution, and for drug design. While analytical methods like the Kabsch algorithm provide an exact,…

Quantitative Methods · Quantitative Biology 2025-08-26 Yue Hu , Zanxia Cao , Yingchao Liu

Radiology report generation represents a significant application within medical AI, and has achieved impressive results. Concurrently, large language models (LLMs) have demonstrated remarkable performance across various domains. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Haifeng Zhao , Yufei Zhang , Leilei Ma , Shuo Xu , Dengdi Sun

The importance of Localized Molecular Orbitals in correlation treatments beyond mean-field calculation and in the illustration of chemical bonding can hardly be overstated. However, generation of orthonormal localized occupied MOs is…

Chemical Physics · Physics 2023-06-09 Aliakbar Sepehri , Run R. Li , Mark R. Hoffmann

The present study presents a comprehensive theoretical investigation of atom and asymmetric top molecule inelastic scattering based on the R-matrix formalism. The proposed methodology establishes a rigorous framework for treating inelastic…

Given samples from two joint distributions, we consider the problem of Optimal Transportation (OT) between them when conditioned on a common variable. We focus on the general setting where the conditioned variable may be continuous, and the…

Machine Learning · Computer Science 2024-06-12 Piyushi Manupriya , Rachit Keerti Das , Sayantan Biswas , Saketha Nath Jagarlapudi

We study the combination of orbital-optimized density cumulant theory and a new parameterization of the reduced density matrices in which the variables are the particle-hole cumulant elements. We call this combination O$\lambda$DCT. We find…

Chemical Physics · Physics 2022-01-12 Jonathon P. Misiewicz , Justin M. Turney , Henry F. Schaefer

Optimal transport (OT) distances between probability distributions are parameterized by the ground metric they use between observations. Their relevance for real-life applications strongly hinges on whether that ground metric parameter is…

Machine Learning · Statistics 2020-11-06 Matthieu Heitz , Nicolas Bonneel , David Coeurjolly , Marco Cuturi , Gabriel Peyré

Origin-Destination Matrix (ODM) estimation is a classical problem in transport engineering aiming to recover flows from every Origin to every Destination from measured traffic counts and a priori model information. In addition to traffic…

Optimization and Control · Mathematics 2019-07-18 Gabriel Michau , Nelly Pustelnik , Pierre Borgnat , Patrice Abry , Alfredo Nantes , Ashish Bhaskar , Edward Chung

Molecular-orbital-based machine learning (MOB-ML) provides a general framework for the prediction of accurate correlation energies at the cost of obtaining molecular orbitals. We demonstrate the importance of preserving physical…

Chemical Physics · Physics 2021-03-17 Tamara Husch , Jiace Sun , Lixue Cheng , Sebastian J. R. Lee , Thomas F. Miller

Aligning EM density maps and fitting atomic models are essential steps in single particle cryogenic electron microscopy (cryo-EM), with recent methods leveraging various algorithms and machine learning tools. As aligning maps remains…

Biomolecules · Quantitative Biology 2023-11-03 Aryan Tajmir Riahi , Chenwei Zhang , James Chen , Anne Condon , Khanh Dao Duc

Optimal Transport (OT) problem investigates a transport map that bridges two distributions while minimizing a given cost function. In this regard, OT between tractable prior distribution and data has been utilized for generative modeling…

Computer Vision and Pattern Recognition · Computer Science 2024-02-07 Jaemoo Choi , Jaewoong Choi , Myungjoo Kang

Comparing structured data from possibly different metric-measure spaces is a fundamental task in machine learning, with applications in, e.g., graph classification. The Gromov-Wasserstein (GW) discrepancy formulates a coupling between the…

Machine Learning · Computer Science 2022-07-12 Hongwei Jin , Zishun Yu , Xinhua Zhang

Deep generative models have shown promise for modeling metal-organic frameworks (MOFs), but existing approaches (1) rely on coarse-grained representations that assume fixed bond lengths and angles, and (2) neglect the MOF-adsorbate…

Materials Science · Physics 2026-02-10 Nayoung Kim , Honghui Kim , Sihyun Yu , Minkyu Kim , Seongsu Kim , Sungsoo Ahn

Applications such as unbalanced and fully shuffled regression can be approached by optimizing regularized optimal transport (OT) distances, such as the entropic OT and Sinkhorn distances. A common approach for this optimization is to use a…

Numerical Analysis · Mathematics 2024-10-22 Xingjie Li , Fei Lu , Molei Tao , Felix X. -F. Ye

Manifold learning is a central task in modern statistics and data science. Many datasets (cells, documents, images, molecules) can be represented as point clouds embedded in a high dimensional ambient space, however the degrees of freedom…

Machine Learning · Statistics 2025-02-18 Stephen Zhang , Gilles Mordant , Tetsuya Matsumoto , Geoffrey Schiebinger

This paper studies the Partial Optimal Transport (POT) problem between two unbalanced measures with at most $n$ supports and its applications in various AI tasks such as color transfer or domain adaptation. There is hence the need for fast…

Machine Learning · Computer Science 2023-12-25 Anh Duc Nguyen , Tuan Dung Nguyen , Quang Minh Nguyen , Hoang H. Nguyen , Lam M. Nguyen , Kim-Chuan Toh

The general procedure underlying Hartree-Fock and Kohn-Sham density functional theory calculations consists in optimizing orbitals for a self-consistent solution of the Roothaan-Hall equations in an iterative process. It is often ignored…

Chemical Physics · Physics 2017-03-16 Alain C. Vaucher , Markus Reiher

Diffusion Models (DMs) have achieved remarkable progress in generative modeling. However, the mismatch between the forward terminal distribution and reverse initial distribution introduces prior error, leading to deviations of sampling…

Machine Learning · Computer Science 2026-02-06 Zhanpeng Wang , Shenghao Li , Jiameng Che , Chen Wang , Shangling Jui , Na Lei , Zhongxuan Luo
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