Related papers: When Blood Parts Ways: Phase Separation in Microst…
Spontaneous phase separation, or demixing, is important in biological phenomena such as cell sorting. In particle-based models, an open question is whether differences in diffusivity can drive such demixing. While…
We present a numerical analysis of the lateral movement and equilibrium radial positions of red blood cells (RBCs) with major diameter of 8 $\mu$m under a Newtonian fluid in a circular channel with 50-$\mu$m diameter. Each RBC, modelled as…
The stress-free state (SFS) of red blood cells (RBCs) is a fundamental reference configuration for the calibration of computational models, yet it remains unknown. Current experimental methods cannot measure the SFS of cells without…
Phase separation can drive spatial organization of multicomponent mixtures. For instance in developing animal embryos, effective phase separation descriptions have been used to account for the spatial organization of different tissue types.…
Flux of rigid or soft particles (such as drops, vesicles, red blood cells, etc.) in a channel is a complex function of particle concentration, which depends on the details of induced dissipation and suspension structure due to hydrodynamic…
The reversible aggregation of red blood cells (RBCs) is a process of erythrocytes clumping that strongly influences the rheological properties of blood. The adhesion of RBCs has been studied extensively in the frame of cell-to-cell…
Centrifugation is a commonly performed laboratory procedure that helps to separate blood cells such as $RBCs$, $WBCs$, and platelets from plasma or serum. Although centrifugation is a routine procedure in most medical laboratories, the…
Red blood cells (RBCs) sustain mechanical stresses associated with microcirculatory flow through ATP-driven plasma membrane flickering. This is an active phenomenon driven by motor proteins that regulate interactions between the spectrin…
The study of vesicles under flow, a model system for red blood cells (RBCs), is an essential step in understanding various intricate dynamics exhibited by RBCs in vivo and in vitro. Quantitative 3D analyses of vesicles under flow are…
We investigate the effect of particle volume fraction on the efficiency of deterministic lateral displacement (DLD) devices. DLD is a popular passive sorting technique for microfluidic applications. Yet, it has been designed for treating…
Phase separation of various materials has been studied for one and a half centuries. In the last two decades, phase separation of proteins and nucleic acids has received enormous attention, due its relevance to cellular functions. However,…
The dynamics of red blood cells (RBCs) in simple shear flow was studied using a theoretical approach based on three variables: a shape parameter, the inclination angle $\theta$, and phase angle $\phi$ of the membrane rotation. At high shear…
Cell cortex contraction is essential for shaping cells, enabling movement, ensuring proper division, maintaining tissue integrity, guiding development, and responding to mechanical signals - all critical for the life and health of…
Flowing blood displays a phenomenon called margination, in which leukocytes and platelets are preferentially found near blood vessel walls, while erythrocytes are depleted from these regions. Here margination is investigated using direct…
We present a numerical analysis of the rheology of a suspension of red blood cells (RBCs) for different volume fractions in a wall-bounded, effectively inertialess, small amplitude oscillatory shear (SAOS) flow for a wide range of applied…
We present a generic mechanism by which reproducing microorganisms, with a diffusivity that depends on the local population density, can form stable patterns. It is known that a decrease of swimming speed with density can promote separation…
We investigate the shear thinning of red blood cell - dextran suspensions. Microscopic images show that at low polymer concentration, aggregation increases with increasing concentration until it reaches a maximum and then decreases again to…
We consider the motion of red blood cells and other non-spherical microcapsules dilutely suspended in a simple shear flow. Our analysis indicates that depending on the viscosity, membrane elasticity, geometry and shear rate, the particle…
Partitioning of (bio)materials in polymeric mixtures is a key phenomenon both in cellular environments, as well as in industrial applications. In cells, several macromolecules are suspended within different biomolecular phases. On the other…
We present a microfluidic platform for the continuous separation of suspended particles based on their size and settling velocity. The separation method takes advantage of the flow field in the vicinity and inside a parallel array of…