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Cryo-electron microscopy (cryo-EM) is a powerful technique in structural biology and drug discovery, enabling the study of biomolecules at high resolution. Significant advancements by structural biologists using cryo-EM have led to the…

Biomolecules · Quantitative Biology 2024-12-05 Yi Zhou , Yilai Li , Jing Yuan , Quanquan Gu

The success of deep neural networks often relies on a large amount of labeled examples, which can be difficult to obtain in many real scenarios. To address this challenge, unsupervised methods are strongly preferred for training neural…

Computer Vision and Pattern Recognition · Computer Science 2019-03-26 Liheng Zhang , Guo-Jun Qi , Liqiang Wang , Jiebo Luo

Objective: Ultrasound Shear Wave Elastography (SWE) demonstrates great potential in assessing soft-tissue pathology by mapping tissue stiffness, which is linked to malignancy. Traditional SWE methods have shown promise in estimating tissue…

Image and Video Processing · Electrical Eng. & Systems 2025-05-27 Ahsan Habib Akash , MD Jahin Alam , Md. Kamrul Hasan

In the intention of minimizing excessive X-ray radiation administration to patients, low-dose computed tomography (LDCT) has become a distinct trend in radiology. However, while lowering the radiation dose reduces the risk to the patient,…

Medical Physics · Physics 2022-04-12 Long Zhou , Xiaozhuang Wang , Min Hou , Ping Li , Chunlong Fu , Yanjun Ren , Tingting Shao , Xi Hu , Jihong Sun , Hongwei Ye

Seismic exploration remains the most critical method for characterizing subsurface structures in geophysics. However, complex surface conditions often cause a non-uniform distribution of seismic receivers along survey lines, leading to…

Image and Video Processing · Electrical Eng. & Systems 2026-03-09 Mingwei Wang , Junheng Peng , Yingtian Liu , Yong Li

Low-Dose computer tomography (LDCT) is an ideal alternative to reduce radiation risk in clinical applications. Although supervised-deep-learning-based reconstruction methods have demonstrated superior performance compared to conventional…

Image and Video Processing · Electrical Eng. & Systems 2024-05-24 Feng Wang , Renfang Wang , Hong Qiu

Pretraining CNN models (i.e., UNet) through self-supervision has become a powerful approach to facilitate medical image segmentation under low annotation regimes. Recent contrastive learning methods encourage similar global representations…

Computer Vision and Pattern Recognition · Computer Science 2023-10-20 Zhangsihao Yang , Mengwei Ren , Kaize Ding , Guido Gerig , Yalin Wang

This work studies the sample complexity of the multi-target detection (MTD) problem, which involves recovering a signal from a noisy measurement containing multiple instances of a target signal in unknown locations, each transformed by a…

Signal Processing · Electrical Eng. & Systems 2025-01-22 Amnon Balanov , Shay Kreymer , Tamir Bendory

In X-ray Computed Tomography (CT), projections from many angles are acquired and used for 3D reconstruction. To make CT suitable for in-line quality control, reducing the number of angles while maintaining reconstruction quality is…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Tianyuan Wang , Felix Lucka , Tristan van Leeuwen

Due to the extremely low signal-to-noise ratio (SNR) and unknown poses (projection angles and image shifts) in cryo-electron microscopy (cryo-EM) experiments, reconstructing 3D volumes from 2D images is very challenging. In addition to…

Image and Video Processing · Electrical Eng. & Systems 2024-04-24 Weijie Chen , Yuhang Wang , Lin Yao

Many current deep learning approaches make extensive use of backbone networks pre-trained on large datasets like ImageNet, which are then fine-tuned to perform a certain task. In remote sensing, the lack of comparable large annotated…

Computer Vision and Pattern Recognition · Computer Science 2024-08-22 Konrad Heidler , Lichao Mou , Di Hu , Pu Jin , Guangyao Li , Chuang Gan , Ji-Rong Wen , Xiao Xiang Zhu

We propose a method to reconstruct the 3-D molecular structure from micrographs collected at just one sample tilt angle in the random conical tilt scheme in cryo-electron microscopy. Our method uses autocorrelation analysis on the…

Data Analysis, Statistics and Probability · Physics 2021-01-12 Ti-Yen Lan , Nicolas Boumal , Amit Singer

Microstructural evolution is a key aspect of understanding and exploiting the structure-property-performance relation of materials. Modeling microstructure evolution usually relies on coarse-grained simulations with evolution principles…

Materials Science · Physics 2020-09-01 Kaiqi Yang , Yifan Cao , Youtian Zhang , Ming Tang , Daniel Aberg , Babak Sadigh , Fei Zhou

Single particle cryo-electron microscopy (EM) is an increasingly popular method for determining the 3-D structure of macromolecules from noisy 2-D images of single macromolecules whose orientations and positions are random and unknown. One…

Computer Vision and Pattern Recognition · Computer Science 2017-04-11 Roy R. Lederman , Amit Singer

We present an electrocardiogram (ECG) -based emotion recognition system using self-supervised learning. Our proposed architecture consists of two main networks, a signal transformation recognition network and an emotion recognition network.…

Machine Learning · Computer Science 2020-04-14 Pritam Sarkar , Ali Etemad

Deep learning model trained by imbalanced data may not work satisfactorily since it could be determined by major classes and thus may ignore the classes with small amount of data. In this paper, we apply deep learning based imbalanced data…

Image and Video Processing · Electrical Eng. & Systems 2019-08-28 Ziqian Luo , Xiangrui Zeng , Zhipeng Bao , Min Xu

The mathematical problem for Electrical Impedance Tomography (EIT) is a highly nonlinear ill-posed inverse problem requiring carefully designed reconstruction procedures to ensure reliable image generation. D-bar methods are based on a…

Numerical Analysis · Mathematics 2018-05-09 Sarah Jane Hamilton , Andreas Hauptmann

Three-dimensional reconstruction of atomic structure, known as atomic electron tomography (AET), has found increasing applications in materials science. The AET has been limited to very small nanoparticles due to the challenges of obtaining…

Materials Science · Physics 2024-01-24 Liangze Mao , Jizhe Cui , Rong Yu

Compressive sensing (CS) has proved effective for tomographic reconstruction from sparsely collected data or under-sampled measurements, which are practically important for few-view CT, tomosynthesis, interior tomography, and so on. To…

Medical Physics · Physics 2018-02-13 Hu Chen , Yi Zhang , Yunjin Chen , Junfeng Zhang , Weihua Zhang , Huaiqiaing Sun , Yang Lv , Peixi Liao , Jiliu Zhou , Ge Wang

Electron cryo-microscopy (cryo-EM) produces three-dimensional (3D) maps of the electrostatic potential of biological macromolecules, including proteins. Along with knowledge about the imaged molecules, cryo-EM maps allow de novo atomic…

Quantitative Methods · Quantitative Biology 2023-02-09 Kiarash Jamali , Dari Kimanius , Sjors H. W. Scheres