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We present TFF, which is a Transformer framework for the analysis of functional Magnetic Resonance Imaging (fMRI) data. TFF employs a two-phase training approach. First, self-supervised training is applied to a collection of fMRI scans,…

Image and Video Processing · Electrical Eng. & Systems 2022-08-16 Itzik Malkiel , Gony Rosenman , Lior Wolf , Talma Hendler

Both functional and structural magnetic resonance imaging (fMRI and sMRI) are widely used for the diagnosis of mental disorder. However, combining complementary information from these two modalities is challenging due to their…

Image and Video Processing · Electrical Eng. & Systems 2024-04-02 Ziyu Zhou , Anton Orlichenko , Gang Qu , Zening Fu , Vince D Calhoun , Zhengming Ding , Yu-Ping Wang

Human perception plays a vital role in forming beliefs and understanding reality. A deeper understanding of brain functionality will lead to the development of novel deep neural networks. In this work, we introduce a novel framework named…

Computer Vision and Pattern Recognition · Computer Science 2024-11-27 Xuan-Bac Nguyen , Xin Li , Pawan Sinha , Samee U. Khan , Khoa Luu

The self-attention mechanism (SAM) has demonstrated remarkable success in various applications. However, training SAM on classical computers becomes computationally challenging as the number of trainable parameters grows. Quantum neural…

Accurate brain age estimation from structural MRI is a valuable biomarker for studying aging and neurodegeneration. Traditional regression and CNN-based methods face limitations such as manual feature engineering, limited receptive fields,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Wasif Jalal , Md Nafiu Rahman , Atif Hasan Rahman , M. Sohel Rahman

We investigate whether and how we can improve the cost efficiency of neuroimaging studies with well-tailored fMRI tasks. The comparative study is conducted using a novel network science-driven Bayesian connectome-based predictive method,…

Applications · Statistics 2024-11-05 Xinzhi Zhang , Leslie A Hulvershorn , Todd Constable , Yize Zhao , Selena Wang

With increasing life expectancy, AD has become a major global health concern. While classical AI-based methods have been developed for early diagnosis and stage classification of AD, growing data volumes and limited computational resources…

Machine Learning · Computer Science 2026-02-03 Emine Akpinar , Murat Oduncuoglu

Localizing neuronal activity in the brain, both in time and in space, is a central challenge to advance the understanding of brain function. Because of the inability of any single neuroimaging techniques to cover all aspects at once, there…

Neurons and Cognition · Quantitative Biology 2013-07-09 Yaroslav O. Halchenko , Michael Hanke , James V. Haxby , Stephen Jose Hanson , Christoph S. Herrmann

Understanding brain dynamics is important for neuroscience and mental health. Functional magnetic resonance imaging (fMRI) enables the measurement of neural activities through blood-oxygen-level-dependent (BOLD) signals, which represent…

Neurons and Cognition · Quantitative Biology 2025-06-16 Yifei Sun , Daniel Chahine , Qinghao Wen , Tianming Liu , Xiang Li , Yixuan Yuan , Fernando Calamante , Jinglei Lv

Dynamic functional connectivity (dFC) using resting-state functional magnetic resonance imaging (rs-fMRI) is an advanced technique for capturing the dynamic changes of neural activities, and can be very useful in the studies of brain…

Image and Video Processing · Electrical Eng. & Systems 2025-01-29 Jing Zhang , Yanjun Lyu , Xiaowei Yu , Lu Zhang , Chao Cao , Tong Chen , Minheng Chen , Yan Zhuang , Tianming Liu , Dajiang Zhu

This paper proposes a novel self-supervised learning method, RELAX-MORE, for quantitative MRI (qMRI) reconstruction. The proposed method uses an optimization algorithm to unroll a model-based qMRI reconstruction into a deep learning…

Biological Physics · Physics 2023-07-26 Wanyu Bian , Albert Jang , Fang Liu

The objective of this paper is to provide a temporal dynamic model for resting state functional Magnetic Resonance Imaging (fMRI) trajectory to predict future brain images based on the given sequence. To this end, we came up with the model…

Signal Processing · Electrical Eng. & Systems 2020-11-17 Zheyu Wen

Autism spectrum disorder(ASD) is a lifelong neurodevelopmental condition that affects social communication and behavior. Investigating functional magnetic resonance imaging (fMRI)-based brain functional connectome can aid in the…

Neurons and Cognition · Quantitative Biology 2023-07-21 Anushree Bannadabhavi , Soojin Lee , Wenlong Deng , Xiaoxiao Li

Many existing methods that use functional magnetic resonance imaging (fMRI) classify brain disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), often overlook the integration of spatial and…

Image and Video Processing · Electrical Eng. & Systems 2025-08-08 Wenhao Dong , Yueyang Li , Weiming Zeng , Lei Chen , Hongjie Yan , Wai Ting Siok , Nizhuan Wang

Resting-state functional Magnetic Resonance Imaging (R-fMRI) holds the promise to reveal functional biomarkers of neuropsychiatric disorders. However, extracting such biomarkers is challenging for complex multi-faceted neuropatholo-gies,…

The human brain can be conceptualized as a dynamical system. Utilizing resting state fMRI time series imaging, we can study the underlying dynamics at ear-marked Regions of Interest (ROIs) to understand structure or lack thereof. This…

Computer Vision and Pattern Recognition · Computer Science 2023-12-01 Ninad Aithal , Chakka Sai Pradeep , Neelam Sinha

Functional magnetic resonance imaging (fMRI) enables non-invasive brain disorder classification by capturing blood-oxygen-level-dependent (BOLD) signals. However, most existing methods rely on functional connectivity (FC) via Pearson…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Guoqi Yu , Xiaowei Hu , Angelica I. Aviles-Rivero , Anqi Qiu , Shujun Wang

Deep learning has advanced fMRI analysis, yet it remains unclear which architectural inductive biases are most effective at capturing functional patterns in human brain activity. This issue is particularly important in small-sample…

Neurons and Cognition · Quantitative Biology 2025-09-23 Behdad Khodabandehloo , Reza Rajimehr

Anomalies in multivariate time series often arise from temporal context and cross-channel coordination rather than isolated outliers. We present Pi-Transformer (Prior-Informed Transformer), a transformer with two attention pathways:…

Machine Learning · Computer Science 2026-03-20 Sepehr Maleki , Negar Pourmoazemi

Quantum computing has emerged as a powerful tool for solving complex problems intractable for classical computers, particularly in popular fields such as cryptography, optimization, and neurocomputing. In this paper, we present a new…

Quantum Physics · Physics 2024-09-24 Xuan-Bac Nguyen , Hoang-Quan Nguyen , Hugh Churchill , Samee U. Khan , Khoa Luu
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