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Generative models have the potential to accelerate key steps in the discovery of novel molecular therapeutics and materials. Diffusion models have recently emerged as a powerful approach, excelling at unconditional sample generation and,…

Biomolecules · Quantitative Biology 2024-07-17 Leo Klarner , Tim G. J. Rudner , Garrett M. Morris , Charlotte M. Deane , Yee Whye Teh

In the field of behavior-related brain computation, it is necessary to align raw neural signals against the drastic domain shift among them. A foundational framework within neuroscience research posits that trial-based neural population…

Neurons and Cognition · Quantitative Biology 2024-03-12 Yule Wang , Zijing Wu , Chengrui Li , Anqi Wu

Diffusion models are state-of-the-art generative models on data modalities such as images, audio, proteins and materials. These modalities share the property of exponentially decaying variance and magnitude in the Fourier domain. Under the…

Spatiotemporal data mining plays an important role in air quality monitoring, crowd flow modeling, and climate forecasting. However, the originally collected spatiotemporal data in real-world scenarios is usually incomplete due to sensor…

Machine Learning · Computer Science 2023-02-21 Mingzhe Liu , Han Huang , Hao Feng , Leilei Sun , Bowen Du , Yanjie Fu

Understanding current energy consumption behavior in communities is critical for informing future energy use decisions and enabling efficient energy management. Urban energy models, which are used to simulate these energy use patterns,…

Computational Engineering, Finance, and Science · Computer Science 2026-04-03 Saumya Sinha , Alexandre Cortiella , Rawad El Kontar , Andrew Glaws , Ryan King , Patrick Emami

The conditional diffusion model (CDM) enhances the standard diffusion model by providing more control, improving the quality and relevance of the outputs, and making the model adaptable to a wider range of complex tasks. However, inaccurate…

Machine Learning · Computer Science 2024-08-07 Weifeng Xu , Xiang Zhu , Xiaoyong Li

Causal discovery serves a pivotal role in mitigating model uncertainty through recovering the underlying causal mechanisms among variables. In many practical domains, such as healthcare, access to the data gathered by individual entities is…

Machine Learning · Computer Science 2024-02-13 Amin Abyaneh , Nino Scherrer , Patrick Schwab , Stefan Bauer , Bernhard Schölkopf , Arash Mehrjou

Here we introduce Partially Observed Structural Causal Models (POSCMs) that formalize causal systems where latent contexts co-determine both the interaction structure and downstream mechanisms on observed variables. POSCMs provide an…

Machine Learning · Computer Science 2026-05-06 Turan Orujlu , Jordan Matelsky , Martin V. Butz , Charley M. Wu , Konrad P. Kording

Data fusion techniques integrate information from heterogeneous data sources to improve learning, generalization, and decision making across data sciences. In causal inference, these methods leverage rich observational data to improve…

Methodology · Statistics 2025-06-02 Quinn Lanners , Cynthia Rudin , Alexander Volfovsky , Harsh Parikh

Generative modelling over continuous-time geometric constructs, a.k.a such as handwriting, sketches, drawings etc., have been accomplished through autoregressive distributions. Such strictly-ordered discrete factorization however falls…

Machine Learning · Computer Science 2023-04-11 Ayan Das , Yongxin Yang , Timothy Hospedales , Tao Xiang , Yi-Zhe Song

Generating counterfactual explanations is one of the most effective approaches for uncovering the inner workings of black-box neural network models and building user trust. While remarkable strides have been made in generative modeling…

Machine Learning · Computer Science 2023-12-22 Nishtha Madaan , Srikanta Bedathur

Probabilistic diffusion models have achieved state-of-the-art results for image synthesis, inpainting, and text-to-image tasks. However, they are still in the early stages of generating complex 3D shapes. This work proposes Diffusion-SDF, a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-17 Gene Chou , Yuval Bahat , Felix Heide

Realistic temporal dynamics are crucial for many video generation, processing and modelling applications, e.g. in computational fluid dynamics, weather prediction, or long-term climate simulations. Video diffusion models (VDMs) are the…

Machine Learning · Computer Science 2025-05-16 Philipp Hess , Maximilian Gelbrecht , Christof Schötz , Michael Aich , Yu Huang , Shangshang Yang , Niklas Boers

Answering counterfactual queries has important applications such as explainability, robustness, and fairness but is challenging when the causal variables are unobserved and the observations are non-linear mixtures of these latent variables,…

Machine Learning · Computer Science 2024-04-16 Zeyu Zhou , Ruqi Bai , Sean Kulinski , Murat Kocaoglu , David I. Inouye

Simulating spatiotemporal turbulence with high fidelity remains a cornerstone challenge in computational fluid dynamics (CFD) due to its intricate multiscale nature and prohibitive computational demands. Traditional approaches typically…

Fluid Dynamics · Physics 2024-07-01 Xiantao Fan , Deepak Akhare , Jian-Xun Wang

Most tabular-data generators match marginal statistics yet ignore causal structure, leading downstream models to learn spurious or unfair patterns. We present TabSCM, a mixed-type generator that preserves those causal dependencies. Starting…

Machine Learning · Computer Science 2026-04-27 Sven Jacob , Bardh Prenkaj , Weijia Shao , Gjergji Kasneci

Over the past few decades, addressing "spatial confounding" has become a major topic in spatial statistics. However, the literature has provided conflicting definitions, and many proposed solutions are tied to specific analysis models and…

Methodology · Statistics 2024-10-14 Brian Gilbert , Abhirup Datta , Joan A. Casey , Elizabeth L. Ogburn

Spatial time series imputation is critically important to many real applications such as intelligent transportation and air quality monitoring. Although recent transformer and diffusion model based approaches have achieved significant…

Machine Learning · Computer Science 2023-09-06 Shunyang Zhang , Senzhang Wang , Xianzhen Tan , Ruochen Liu , Jian Zhang , Jianxin Wang

Generating high-quality synthetic time series is a fundamental yet challenging task across domains such as forecasting and anomaly detection, where real data can be scarce, noisy, or costly to collect. Unlike static data generation,…

Machine Learning · Computer Science 2025-09-25 MohammadReza EskandariNasab , Shah Muhammad Hamdi , Soukaina Filali Boubrahimi

Many real-world decision-making tasks require learning causal relationships between a set of variables. Traditional causal discovery methods, however, require that all variables are observed, which is often not feasible in practical…

Methodology · Statistics 2023-06-27 Raj Agrawal , Chandler Squires , Neha Prasad , Caroline Uhler