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Prokaryotic viruses, which infect bacteria and archaea, are key players in microbial communities. Predicting the hosts of prokaryotic viruses helps decipher the dynamic relationship between microbes. Experimental methods for host prediction…

Genomics · Quantitative Biology 2023-01-02 Jiayu Shang , Yanni Sun

The structural identifiability and the observability of a model determine the possibility of inferring its parameters and states by observing its outputs. These properties should be analysed before attempting to calibrate a model.…

Systems and Control · Electrical Eng. & Systems 2022-10-18 Xabier Rey Barreiro , Alejandro F. Villaverde

Protein-protein interactions (PPIs) between a virus and its host govern infection, replication, and pathogenesis. While high-throughput mapping has identified thousands of virus-host associations, much of the virus-host interactome remains…

In modern computing environments, users may have multiple systems accessible to them such as local clusters, private clouds, or public clouds. This abundance of choices makes it difficult for users to select the system and configuration for…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-04-05 Amir Nassereldine , Safaa Diab , Mohammed Baydoun , Kenneth Leach , Maxim Alt , Dejan Milojicic , Izzat El Hajj

Identifying viral pathogens and characterizing their transmission is essential to developing effective public health measures in response to a pandemic. Phylogenetics, though currently the most popular tool used to characterize the likely…

Quantitative Methods · Quantitative Biology 2015-05-28 Anil Raj , Michael Dewar , Gustavo Palacios , Raul Rabadan , Chris H. Wiggins

Currently, many verification algorithms are available to improve the reliability of software systems. Selecting the appropriate verification algorithm typically demands domain expertise and non-trivial manpower. An automated algorithm…

Software Engineering · Computer Science 2025-05-26 Jie Su , Liansai Deng , Cheng Wen , Rong Wang , Zhi Ma , Nan Zhang , Cong Tian , Zhenhua Duan , Shengchao Qin

Pursuing invariant prediction from heterogeneous environments opens the door to learning causality in a purely data-driven way and has several applications in causal discovery and robust transfer learning. However, existing methods such as…

Statistics Theory · Mathematics 2025-01-30 Yihong Gu , Cong Fang , Yang Xu , Zijian Guo , Jianqing Fan

Polygenic risk score (PRS) tools differ substantially in statistical assumptions, input requirements, and implementation complexity, making direct comparison difficult. We developed a harmonized, implementation-aware benchmarking framework…

Genomics · Quantitative Biology 2026-03-24 Muhammad Muneeb , David B. Ascher

Accurate prediction of application performance is critical for enabling effective scheduling and resource management in resource-constrained dynamic edge environments. However, achieving predictable performance in such environments remains…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-24 Panagiotis Giannakopoulos , Bart van Knippenberg , Kishor Chandra Joshi , Nicola Calabretta , George Exarchakos

Collaborative filtering or recommender systems use a database about user preferences to predict additional topics or products a new user might like. In this paper we describe several algorithms designed for this task, including techniques…

Information Retrieval · Computer Science 2013-02-01 John S. Breese , David Heckerman , Carl Kadie

Performance variability is an important measure for a reliable high performance computing (HPC) system. Performance variability is affected by complicated interactions between numerous factors, such as CPU frequency, the number of…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-12-16 Li Xu , Thomas Lux , Tyler Chang , Bo Li , Yili Hong , Layne Watson , Ali Butt , Danfeng Yao , Kirk Cameron

Predictive modelling is important for health data analysis and data-driven clinical decision-making. However, predictive studies are challenging to design optimally by hand when tens or even hundreds of features require selection,…

Predictive modelling is vital to guide preventive efforts. Whilst large-scale prospective cohort studies and a diverse toolkit of available machine learning (ML) algorithms have facilitated such survival task efforts, choosing the…

Identifying which software versions are affected by a vulnerability is critical for patching, risk mitigation. Despite a growing body of tools, their real-world effectiveness remains unclear due to narrow evaluation scopes often limited to…

Software Engineering · Computer Science 2025-09-10 Xingchu Chen , Chengwei Liu , Jialun Cao , Yang Xiao , Xinyue Cai , Yeting Li , Jingyi Shi , Tianqi Sun , Haiming Chen ang Wei Huo

Viral infections are causing significant morbidity and mortality worldwide. Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection…

Machine Learning · Computer Science 2021-11-30 Thi Ngan Dong , Graham Brogden , Gisa Gerold , Megha Khosla

Although high-performance computing (HPC) systems have been scaled to meet the exponentially-growing demand for scientific computing, HPC performance variability remains a major challenge and has become a critical research topic in computer…

Applications · Statistics 2022-05-23 Li Xu , Yili Hong , Max D. Morris , Kirk W. Cameron

The histological assessment of human tissue has emerged as the key challenge for detection and treatment of cancer. A plethora of different data sources ranging from tissue microarray data to gene expression, proteomics or metabolomics data…

Computer Vision and Pattern Recognition · Computer Science 2016-01-05 Thomas J. Fuchs , Joachim M. Buhmann

Motivation: Machine learning based prediction of compound-protein interactions (CPIs) is important for drug design, screening and repurposing studies and can improve the efficiency and cost-effectiveness of wet lab assays. Despite the…

Quantitative Methods · Quantitative Biology 2022-02-02 Adiba Yaseen , Imran Amin , Naeem Akhter , Asa Ben-Hur , Fayyaz Minhas

Exploring causal relationships for qualitative data analysis in HCI and social science research enables the understanding of user needs and theory building. However, current computational tools primarily characterize and categorize…

Human-Computer Interaction · Computer Science 2026-02-09 Han Meng , Qiuyuan Lyu , Peinuan Qin , Yitian Yang , Renwen Zhang , Wen-Chieh Lin , Yi-Chieh Lee

In recent years, substantial advancements have been achieved in understanding the diversity of the human virome and its intricate roles in human health and diseases. Despite this progress, the field of human virome research remains nascent,…

Quantitative Methods · Quantitative Biology 2024-02-26 Yifan Wu , Yousong Peng
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