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Generative models have the potential to accelerate key steps in the discovery of novel molecular therapeutics and materials. Diffusion models have recently emerged as a powerful approach, excelling at unconditional sample generation and,…

Biomolecules · Quantitative Biology 2024-07-17 Leo Klarner , Tim G. J. Rudner , Garrett M. Morris , Charlotte M. Deane , Yee Whye Teh

Diffusion models have emerged as powerful learned priors for solving inverse problems. However, current iterative solving approaches which alternate between diffusion sampling and data consistency steps typically require hundreds or…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Minwoo Kim , Hongki Lim

Conditional diffusion models have exhibited superior performance in high-fidelity text-guided visual generation and editing. Nevertheless, prevailing text-guided visual diffusion models primarily focus on incorporating text-visual…

Computer Vision and Pattern Recognition · Computer Science 2024-06-05 Ling Yang , Zhilong Zhang , Zhaochen Yu , Jingwei Liu , Minkai Xu , Stefano Ermon , Bin Cui

Speech separation, the task of isolating multiple speech sources from a mixed audio signal, remains challenging in noisy environments. In this paper, we propose a generative correction method to enhance the output of a discriminative…

Audio and Speech Processing · Electrical Eng. & Systems 2024-06-12 Helin Wang , Jesus Villalba , Laureano Moro-Velazquez , Jiarui Hai , Thomas Thebaud , Najim Dehak

Classifier guidance is a recently introduced method to trade off mode coverage and sample fidelity in conditional diffusion models post training, in the same spirit as low temperature sampling or truncation in other types of generative…

Machine Learning · Computer Science 2022-07-27 Jonathan Ho , Tim Salimans

Controllable molecular graph generation is essential for material and drug discovery, where generated molecules must satisfy diverse property constraints. While recent advances in graph diffusion models have improved generation quality,…

Machine Learning · Computer Science 2025-09-30 Anjie Qiao , Zhen Wang , Chuan Chen , DeFu Lian , Enhong Chen

Diffusion models have gained attention in speech enhancement tasks, providing an alternative to conventional discriminative methods. However, research on target speech extraction under multi-speaker noisy conditions remains relatively…

Audio and Speech Processing · Electrical Eng. & Systems 2024-10-08 Leying Zhang , Yao Qian , Linfeng Yu , Heming Wang , Hemin Yang , Long Zhou , Shujie Liu , Yanmin Qian

Score-based diffusion models have emerged as powerful techniques for generating samples from high-dimensional data distributions. These models involve a two-phase process: first, injecting noise to transform the data distribution into a…

Machine Learning · Computer Science 2024-10-21 Runjia Li , Qiwei Di , Quanquan Gu

Despite impressive advancements in diffusion-based video editing models in altering video attributes, there has been limited exploration into modifying motion information while preserving the original protagonist's appearance and…

Computer Vision and Pattern Recognition · Computer Science 2024-05-31 Shuyuan Tu , Qi Dai , Zihao Zhang , Sicheng Xie , Zhi-Qi Cheng , Chong Luo , Xintong Han , Zuxuan Wu , Yu-Gang Jiang

Diffusion models are a powerful class of generative models capable of producing high-quality images from pure noise using a simple text prompt. While most methods which introduce additional spatial constraints into the generated images…

Computer Vision and Pattern Recognition · Computer Science 2024-09-18 Zakaria Patel , Kirill Serkh

Diffusion models have recently attained significant interest within the community owing to their strong performance as generative models. Furthermore, its application to inverse problems have demonstrated state-of-the-art performance.…

Image and Video Processing · Electrical Eng. & Systems 2022-03-22 Hyungjin Chung , Byeongsu Sim , Jong Chul Ye

Score-based generative models (SGMs) are powerful tools to sample from complex data distributions. Their underlying idea is to (i) run a forward process for time $T_1$ by adding noise to the data, (ii) estimate its score function, and (iii)…

Machine Learning · Computer Science 2024-06-06 Francesco Pedrotti , Jan Maas , Marco Mondelli

Score-based diffusion models are a powerful class of generative models, widely utilized across diverse domains. Despite significant advancements in large-scale tasks such as text-to-image generation, their application to constrained domains…

Machine Learning · Computer Science 2025-07-15 Saeid Naderiparizi , Xiaoxuan Liang , Setareh Cohan , Berend Zwartsenberg , Frank Wood

Visual-motor policy learning has advanced with architectures like diffusion-based policies, known for modeling complex robotic trajectories. However, their prolonged inference times hinder high-frequency control tasks requiring real-time…

Robotics · Computer Science 2024-12-20 Bofang Jia , Pengxiang Ding , Can Cui , Mingyang Sun , Pengfang Qian , Siteng Huang , Zhaoxin Fan , Donglin Wang

Discrete diffusion has emerged as a powerful framework for generative modeling in discrete domains, yet efficiently sampling from these models remains challenging. Existing sampling strategies often struggle to balance computation and…

Machine Learning · Computer Science 2025-11-12 Yixiu Zhao , Jiaxin Shi , Feng Chen , Shaul Druckmann , Lester Mackey , Scott Linderman

This paper introduces a novel speech enhancement (SE) approach based on a denoising diffusion probabilistic model (DDPM), termed Guided diffusion for speech enhancement (GDiffuSE). In contrast to conventional methods that directly map noisy…

Sound · Computer Science 2026-03-03 Efrayim Yanir , David Burshtein , Sharon Gannot

Score-based diffusion models learn to reverse a stochastic differential equation that maps data to noise. However, for complex tasks, numerical error can compound and result in highly unnatural samples. Previous work mitigates this drift…

Machine Learning · Statistics 2023-06-12 Aaron Lou , Stefano Ermon

Diffusion-based generative models have recently achieved remarkable results in speech and vocal enhancement due to their ability to model complex speech data distributions. While these models generalize well to unseen acoustic environments,…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-23 Yudong Yang , Zhan Liu , Wenyi Yu , Guangzhi Sun , Qiuqiang Kong , Chao Zhang

Score-based generative models (SGMs) have demonstrated remarkable synthesis quality. SGMs rely on a diffusion process that gradually perturbs the data towards a tractable distribution, while the generative model learns to denoise. The…

Machine Learning · Statistics 2022-03-28 Tim Dockhorn , Arash Vahdat , Karsten Kreis

Guidance in conditional diffusion generation is of great importance for sample quality and controllability. However, existing guidance schemes are to be desired. On one hand, mainstream methods such as classifier guidance and…

Machine Learning · Computer Science 2023-10-18 Jiajun Ma , Tianyang Hu , Wenjia Wang , Jiacheng Sun