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In light of recent findings from the kinematic morphology-density relation, we investigate whether the same trends exist in the original morphology density relation, using the same data as Dressler. In addition to Dressler's canonical…
Surface stress and surface energy are two fundamental parameters that determine the surface properties of any materials. While it is commonly believed that the surface stress and surface energy of liquids are identical, the relationship…
It is increasingly being realized that liquid-crystalline features can play an important role in the properties and dynamics of cell monolayers. Here, we present a cell-based model of cell layers, based on the phase-field formulation, that…
The properties of tissue interfaces -- between separate populations of cells, or between a group of cells and its environment -- has attracted intense theoretical, computational, and experimental study. Recent work on shape-based models…
The two-point statistics of the cosmic velocity field, measured from galaxy peculiar velocity (PV) surveys, can be used as a dynamical probe to constrain the growth rate of large-scale structures in the universe. Most works use the…
We present results of the investigations of the statistical properties of a joint density and velocity divergence probability distribution function (PDF) in the mildly non-linear regime. For that purpose we use both perturbation theory…
Plastic deformation of heterogeneous solid structures is often characterized by random intermittent local plastic events. On the mesoscale this feature can be represented by a spatially fluctuating local yield threshold. Here we study the…
Density profiles are the most common measure of inhomogeneous structure in confined fluids, but their connection to transport coefficients is poorly understood. We explore via simulation how tuning particle-wall interactions to flatten or…
Living cells establish long-range orientational order through collective alignment, giving rise to topological defects whose functional relevance is increasingly recognized in tissue organization and morphogenesis. Engineered topographical…
Tissue homeostasis, the biological process of maintaining a steady state in tissue via control of cell proliferation, death, and metabolic function, is essential for the development, growth, maintenance, and proper function of living…
I derive up to second order in Eulerian perturbation theory a new relation between the weakly nonlinear density and velocity fields. In the case of unsmoothed fields, density at a given point turns out to be a purely local function of the…
Many morphogenetic processes involve mechanical rearrangement of epithelial tissues that is driven by precisely regulated cytoskeletal forces and cell adhesion. The mechanical state of the cell and intercellular adhesion are not only the…
Over the past decade, advances in super-resolution microscopy and particle-based modeling have driven an intense interest in investigating spatial heterogeneity at the level of single molecules in cells. Remarkably, it is becoming clear…
Morphogenesis, tissue regeneration and cancer invasion involve transitions in tissue morphology. These transitions, caused by collective cell migration (CCM), have been interpreted as active wetting/de-wetting transitions. This phenomenon…
Quantifying the outcomes of cells collisions is a crucial step in building the foundations of a kinetic theory of living matter. Here, we develop a mechanical theory of such collisions by first representing individual cells as extended…
Mechanical interactions between biological cells may be mediated by secreted products, making them dependent on the local particle density. Here, we explore the generic physics of density-dependent attractive interactions. We show using…
Movement of cell clusters along extracellular matrices (ECM) during tissue development, wound healing, and early stage of cancer invasion involve various inter-connected migration modes such as: (1) cell movement within clusters, (2)…
We apply a recently developed model of cytoskeletal force generation to study a cell intrinsic contractility, as well as its response to external loading. The model is based on a non-equilibrium thermodynamic treatment of the…
The causal connection between congestions and velocity changes at different locations induces various statistical features, which we identify and measure in detail. We carry out an empirical analysis of large-scale traffic data on a local…
It is known that mechanical interactions couple a cell to its neighbors, enabling a feedback loop to regulate tissue growth. However, the interplay between cell-cell adhesion strength, local cell density and force fluctuations in regulating…