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Explainable AI (xAI) interventions aim to improve interpretability for complex black-box models, not only to improve user trust but also as a means to extract scientific insights from high-performing predictive systems. In molecular…

Machine Learning · Computer Science 2025-04-04 Jonas Teufel , Annika Leinweber , Pascal Friederich

To understand the black-box characteristics of deep networks, counterfactual explanation that deduces not only the important features of an input space but also how those features should be modified to classify input as a target class has…

Machine Learning · Computer Science 2022-08-15 Hong-Gyu Jung , Sin-Han Kang , Hee-Dong Kim , Dong-Ok Won , Seong-Whan Lee

Introduction: Computational modeling has rapidly advanced over the last decades, especially to predict molecular properties for chemistry, material science and drug design. Recently, machine learning techniques have emerged as a powerful…

Counterfactual explanation is an important Explainable AI technique to explain machine learning predictions. Despite being studied actively, existing optimization-based methods often assume that the underlying machine-learning model is…

Artificial Intelligence · Computer Science 2022-06-01 Wenzhuo Yang , Jia Li , Caiming Xiong , Steven C. H. Hoi

Machine learning models that operate on graph-structured data, such as molecular graphs or social networks, often make accurate predictions but offer little insight into why certain predictions are made. Counterfactual explanations address…

Machine Learning · Computer Science 2025-11-21 David Bechtoldt , Sidney Bender

Machine learning plays a role in many deployed decision systems, often in ways that are difficult or impossible to understand by human stakeholders. Explaining, in a human-understandable way, the relationship between the input and output of…

Machine Learning · Computer Science 2022-11-17 Sahil Verma , Varich Boonsanong , Minh Hoang , Keegan E. Hines , John P. Dickerson , Chirag Shah

Predicting the chemical properties of compounds is crucial in discovering novel materials and drugs with specific desired characteristics. Recent significant advances in machine learning technologies have enabled automatic predictive…

Quantitative Methods · Quantitative Biology 2021-12-10 Yang Liu , Hisashi Kashima

Currently, there is a significant amount of research being conducted in the field of artificial intelligence to improve the explainability and interpretability of deep learning models. It is found that if end-users understand the reason for…

Information Retrieval · Computer Science 2023-06-02 Niloofar Ranjbar , Saeedeh Momtazi , MohammadMehdi Homayounpour

Counterfactual explanations have emerged as a prominent method in Explainable Artificial Intelligence (XAI), providing intuitive and actionable insights into Machine Learning model decisions. In contrast to other traditional feature…

Recently supervised machine learning has been ascending in providing new predictive approaches for chemical, biological and materials sciences applications. In this Perspective we focus on the interplay of machine learning algorithm with…

Due to the increasing use of machine learning in practice it becomes more and more important to be able to explain the prediction and behavior of machine learning models. An instance of explanations are counterfactual explanations which…

Machine Learning · Computer Science 2019-11-19 André Artelt , Barbara Hammer

Interpretable machine learning seeks to understand the reasoning process of complex black-box systems that are long notorious for lack of explainability. One flourishing approach is through counterfactual explanations, which provide…

Artificial Intelligence · Computer Science 2023-06-02 Vy Vo , Trung Le , Van Nguyen , He Zhao , Edwin Bonilla , Gholamreza Haffari , Dinh Phung

Model interpretability has become an important problem in machine learning (ML) due to the increased effect that algorithmic decisions have on humans. Counterfactual explanations can help users understand not only why ML models make certain…

Machine Learning · Computer Science 2021-12-20 Ana Lucic , Harrie Oosterhuis , Hinda Haned , Maarten de Rijke

Accurate and efficient prediction of the molecular properties of drugs is one of the fundamental problems in drug research and development. Recent advancements in representation learning have been shown to greatly improve the performance of…

Biomolecules · Quantitative Biology 2022-06-17 Hui Liu , Yibiao Huang , Xuejun Liu , Lei Deng

While recent years have witnessed the emergence of various explainable methods in machine learning, to what degree the explanations really represent the reasoning process behind the model prediction -- namely, the faithfulness of…

Computation and Language · Computer Science 2021-09-07 Yingqiang Ge , Shuchang Liu , Zelong Li , Shuyuan Xu , Shijie Geng , Yunqi Li , Juntao Tan , Fei Sun , Yongfeng Zhang

The growing integration of machine learning (ML) and artificial intelligence (AI) models into high-stakes domains such as healthcare and scientific research calls for models that are not only accurate but also interpretable. Among the…

Machine Learning · Computer Science 2025-10-23 Zhuo Cao , Xuan Zhao , Lena Krieger , Hanno Scharr , Ira Assent

The accuracy and understandability of bank failure prediction models are crucial. While interpretable models like logistic regression are favored for their explainability, complex models such as random forest, support vector machines, and…

Machine Learning · Computer Science 2026-04-15 Seyma Gunonu , Gizem Altun , Mustafa Cavus

Counterfactual explanations are viewed as an effective way to explain machine learning predictions. This interest is reflected by a relatively young literature with already dozens of algorithms aiming to generate such explanations. These…

Machine Learning · Computer Science 2022-12-05 Raphael Mazzine , David Martens

Automated analyses of the outcome of a simulation have been an important part of atomistic modeling since the early days, addressing the need of linking the behavior of individual atoms and the collective properties that are usually the…

Chemical Physics · Physics 2019-05-22 Michele Ceriotti

In this paper we argue that, to its detriment, transparency research overlooks many foundational concepts of artificial intelligence. As an illustrating example we focus on uncertainty quantification in the context of counterfactual…

Machine Learning · Computer Science 2026-05-19 Kacper Sokol , Santo M. A. R. Thies , Eyke Hüllermeier
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