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A detailed understanding of biochemical networks at the molecular level is essential for studying complex cellular processes. In this paper, we provide a comprehensive description of biochemical networks by considering individual atoms and…

Molecular Networks · Quantitative Biology 2025-04-08 Hadjar Rahou , Hulda S. Haraldsdottir , Filippo Martinelli , Ines Thiele , Ronan M. T. Fleming

We investigate the reduced dynamics of two identical superconducting qubits capacitively coupled through a finite-length transmission line. Starting from circuit quantization, we derive a circuit Hamiltonian that naturally separates the…

Quantum Physics · Physics 2026-04-24 Fabio Borrelli , Giovanni Miano , Carlo Forestiere

We define a subclass of Chemical Reaction Networks called Post-Translational Modification systems. Important biological examples of such systems include MAPK cascades and two-component systems which are well-studied experimentally as well…

Molecular Networks · Quantitative Biology 2011-07-19 Elisenda Feliu , Carsten Wiuf

There is a renewed interest in the derivation of statistical mechanics from the dynamics of closed quantum systems. A central part of this program is to understand how far-from-equilibrium closed quantum system can behave as if relaxing to…

Key insights in molecular biology, such as enzyme kinetics, protein allostery and gene regulation emerged from quantitative analysis based on time-scale separation, allowing internal complexity to be eliminated and resulting in the…

Molecular Networks · Quantitative Biology 2011-09-29 Jeremy Gunawardena

A recent experiment driving colloids electromagnetically, by B\'erut et al. [2014 Europhys. Lett. 107, 60004], is an ideal paradigm for illustrating a linear response theory for nonequilibrium overdamped systems including hydrodynamic…

Statistical Mechanics · Physics 2016-03-22 Cem Yolcu , Marco Baiesi

Biological systems and processes are networks of complex nonlinear regulatory interactions between nucleic acids, proteins, and metabolites. A natural way in which to represent these interaction networks is through the use of a graph. In…

Molecular Networks · Quantitative Biology 2023-01-04 Jacob Rast

Dynamical systems describe the changes in processes that arise naturally from their underlying physical principles, such as the laws of motion or the conservation of mass, energy or momentum. These models facilitate a causal explanation for…

Methodology · Statistics 2023-10-11 Michelle Carey , James O. Ramsay

A recombination reaction model for high-temperature chemical kinetics is derived from ab initio simulations data. A kinetic recombination rate model is derived using a recently developed ab initio state-specific dissociation model and the…

Chemical Physics · Physics 2020-09-15 Narendra Singh , Thomas Schwartzentruber

Finite-time coherent sets represent minimally mixing objects in general nonlinear dynamics, and are spatially mobile features that are the most predictable in the medium term. When the dynamical system is subjected to small parameter…

Dynamical Systems · Mathematics 2021-04-14 Fadi Antown , Gary Froyland , Oliver Junge

The paper has two goals: It presents basic ideas, notions, and methods for reduction of reaction kinetics models: quasi-steady-state, quasi-equilibrium, slow invariant manifolds, and limiting steps. It describes briefly the current state of…

Chemical Physics · Physics 2022-05-17 A. N. Gorban

The analysis of complex reaction networks is of great importance in several chemical and biochemical fields (interstellar chemistry, prebiotic chemistry, reaction mechanism, etc). In this article, we propose to simultaneously refine and…

Molecular Networks · Quantitative Biology 2008-03-11 Raphaël Plasson , Hugues Bersini , Axel Brandenburg

The trend to equilibrium for reaction-diffusion systems modelling chemical reaction networks is investigated, in the case when reaction processes happen on subsets of the domain. We prove the convergence to equilibrium by directly showing…

Analysis of PDEs · Mathematics 2024-12-17 Laurent Desvillettes , Kim Dang Phung , Bao Quoc Tang

We discuss three different aspects of the quantum dynamics of bio-molecular systems and more generally complex networks in the presence of strongly coupled environments. Firstly, we make a case for the systematic study of fundamental…

Quantum Physics · Physics 2012-02-07 M. B. Plenio , S. F. Huelga

Reaction networks are a general formalism for describing collections of classical entities interacting in a random way. While reaction networks are mainly studied by chemists, they are equivalent to Petri nets, which are used for similar…

Mathematical Physics · Physics 2021-11-23 John C. Baez

In this paper, we provide a detailed theoretical analysis of the numerical scheme introduced in J. Comput. Phys. 436 (2021) 110253 for the reaction kinetics of a class of chemical reaction networks that satisfies detailed balance condition.…

Numerical Analysis · Mathematics 2024-02-07 Chun Liu , Cheng Wang , Yiwei Wang

The automated inference of physically interpretable (bio)chemical reaction network models from measured experimental data is a challenging problem whose solution has significant commercial and academic ramifications. It is demonstrated,…

Neural and Evolutionary Computing · Computer Science 2014-12-22 Dominic P. Searson , Mark J. Willis , Allen Wright

We consider stochastic descriptions of chemical reaction networks in which there are both fast and slow reactions, and for which the time scales are widely separated. We develop a computational algorithm that produces the generator of the…

Dynamical Systems · Mathematics 2015-12-11 Xingye Kan , Chang Hyeong Lee , Hans G. Othmer

The interaction of distinct units in physical, social, biological and technological systems naturally gives rise to complex network structures. Networks have constantly been in the focus of research for the last decade, with considerable…

Physics and Society · Physics 2012-08-20 Tamás Nepusz , Tamás Vicsek

The integration of various types of genomic data into predictive models of biological networks is one of the main challenges currently faced by computational biology. Constraint-based models in particular play a key role in the attempt to…

Molecular Networks · Quantitative Biology 2012-06-25 Daniele De Martino , Matteo Figliuzzi , Andrea De Martino , Enzo Marinari
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