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Direct Preference Optimization (DPO) has emerged as a predominant alignment method for diffusion models, facilitating off-policy training without explicit reward modeling. However, its reliance on large-scale, high-quality human preference…

Computer Vision and Pattern Recognition · Computer Science 2026-02-09 Khiem Pham , Quang Nguyen , Tung Nguyen , Jingsen Zhu , Michele Santacatterina , Dimitris Metaxas , Ramin Zabih

Diffusion models have achieved promising results for Structure-Based Drug Design (SBDD). Nevertheless, high-quality protein subpocket and ligand data are relatively scarce, which hinders the models' generation capabilities. Recently, Direct…

Biomolecules · Quantitative Biology 2026-02-11 Xiwei Cheng , Xiangxin Zhou , Yuwei Yang , Yu Bao , Quanquan Gu

Large Language Models (LLMs) augmented with Knowledge Graphs (KGs) have advanced complex question answering, yet they often remain susceptible to failure when their initial high-level reasoning plan is flawed. This limitation, analogous to…

Computation and Language · Computer Science 2026-02-03 MinGyu Jeon , SuWan Cho , JaeYoung Shu

Normative theories allow one to elicit key parts of a ML algorithm from first principles, which is crucial at a time of championed scrutiny for ML work. Direct Preference Optimization (DPO) cleverly bypasses reward modeling by making an…

Machine Learning · Computer Science 2026-02-05 Wenxuan Zhou , Shujian Zhang , Brice Magdalou , John Lambert , Ehsan Amid , Richard Nock , Andrew Hard

We present SignDPO, a novel multi-level Direct Preference Optimisation (DPO) framework designed to enhance the alignment of skeleton-based Sign Language Translation. While current skeleton-based models have made significant progress using…

Computation and Language · Computer Science 2026-04-21 Muxin Pu , Xiao-Ming Wu , Mei Kuan Lim , Chun Yong Chong , Wei Li , Chen Change Loy

Large language model reasoning is often treated as a monolithic capability, relying on binary preference supervision that fails to capture partial progress or fine-grained reasoning quality. We introduce Continuous Utility Direct Preference…

Recent alignment methods based on Direct Preference Optimization (DPO) reformulate preference learning as supervised optimization over pairwise comparisons, offering improved efficiency and stability over reinforcement learning from human…

Machine Learning · Computer Science 2026-01-22 Yuhui Sun , Xiyao Wang , Zixi Li , YiTian Ding , Tianyang Ling , Jialuo Chen , Tianyi Yu , Zhenlong Yuan , Jinman Zhao

Knowledge Graphs (KGs) are foundational structures in many AI applications, representing entities and their interrelations through triples. However, triple-based KGs lack the contextual information of relational knowledge, like temporal…

Artificial Intelligence · Computer Science 2024-07-01 Chengjin Xu , Muzhi Li , Cehao Yang , Xuhui Jiang , Lumingyuan Tang , Yiyan Qi , Jian Guo

Direct Preference Optimization (DPO) has emerged as a simple and effective approach for aligning large language models (LLMs) with human preferences, bypassing the need for a learned reward model. Despite its growing adoption, a fundamental…

Machine Learning · Computer Science 2025-11-10 Yu Pan , Zhongze Cai , Guanting Chen , Huaiyang Zhong , Chonghuan Wang

The class of direct preference optimization (DPO) algorithms has emerged as a promising approach for solving the alignment problem in foundation models. These algorithms work with very limited feedback in the form of pairwise preferences…

Machine Learning · Computer Science 2026-02-03 Luca Viano , Ruida Zhou , Yifan Sun , Mahdi Namazifar , Volkan Cevher , Shoham Sabach , Mohammad Ghavamzadeh

Direct Preference Optimization (DPO) is an effective technique that leverages pairwise preference data (usually one chosen and rejected response pair per user prompt) to align LLMs to human preferences. In practice, multiple responses can…

Computation and Language · Computer Science 2024-11-11 Pulkit Pattnaik , Rishabh Maheshwary , Kelechi Ogueji , Vikas Yadav , Sathwik Tejaswi Madhusudhan

Novel advanced policy gradient (APG) methods, such as Trust Region policy optimization and Proximal policy optimization (PPO), have become the dominant reinforcement learning algorithms because of their ease of implementation and good…

Optimization and Control · Mathematics 2022-03-22 J. G. Dai , Mark Gluzman

Preference optimization has made significant progress recently, with numerous methods developed to align language models with human preferences. This paper introduces $f$-divergence Preference Optimization ($f$-PO), a novel framework that…

Computation and Language · Computer Science 2025-02-18 Jiaqi Han , Mingjian Jiang , Yuxuan Song , Stefano Ermon , Minkai Xu

Human image generation is a key focus in image synthesis due to its broad applications, but even slight inaccuracies in anatomy, pose, or details can compromise realism. To address these challenges, we explore Direct Preference Optimization…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Sanghyeon Na , Yonggyu Kim , Hyunjoon Lee

Direct Preference Optimization (DPO) is a powerful paradigm for aligning Large Language Models (LLMs) to human preferences in Machine Translation (MT), but current methods are hindered by two fundamental challenges: (1) flawed reward…

Computation and Language · Computer Science 2025-10-16 Hao Wang , Linlong Xu , Heng Liu , Yangyang Liu , Xiaohu Zhao , Bo Zeng , Liangying Shao , Longyue Wang , Weihua Luo , Kaifu Zhang

Language models deployed in online communities must adapt to norms that vary across social, cultural, and domain-specific contexts. Prior alignment approaches rely on explicit preference supervision or predefined principles, which are…

Artificial Intelligence · Computer Science 2026-03-04 Patrick Gerard , Svitlana Volkova

The rapid advancement of embodied intelligence and world models has intensified efforts to integrate physical laws into AI systems, yet physical perception and symbolic physics reasoning have developed along separate trajectories without a…

Large Language Models (LLMs) have achieved impressive results in various tasks but struggle with hallucination problems and lack of relevant knowledge, especially in deep complex reasoning and knowledge-intensive tasks. Knowledge Graphs…

Computation and Language · Computer Science 2025-03-14 Xingyu Tan , Xiaoyang Wang , Qing Liu , Xiwei Xu , Xin Yuan , Wenjie Zhang

Recent advances in alignment techniques such as Supervised Fine-Tuning (SFT), Reinforcement Learning from Human Feedback (RLHF), and Direct Preference Optimization (DPO) have improved the safety of large language models (LLMs). However,…

Computation and Language · Computer Science 2026-02-26 Mengxuan Hu , Vivek V. Datla , Anoop Kumar , Zihan Guan , Sheng Li , Alfy Samuel , Daben Liu

The emergence of Retrieval-augmented generation (RAG) has alleviated the issues of outdated and hallucinatory content in the generation of large language models (LLMs), yet it still reveals numerous limitations. When a general-purpose LLM…

Computation and Language · Computer Science 2024-12-20 Jiayi Wu , Hengyi Cai , Lingyong Yan , Hao Sun , Xiang Li , Shuaiqiang Wang , Dawei Yin , Ming Gao
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