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Electronic Health Records (EHR) contain rich longitudinal patient information and are widely used in predictive modeling applications. However, effectively leveraging historical data remains challenging due to long trajectories,…

Information Retrieval · Computer Science 2026-05-13 Saeed Shurrab , Mariam Al-Omari , Dana El Samad , Farah E. Shamout

Electronic Health Record (EHR) data has been of tremendous utility in Artificial Intelligence (AI) for healthcare such as predicting future clinical events. These tasks, however, often come with many challenges when using classical machine…

Machine Learning · Computer Science 2021-04-08 Tingyi Wanyan , Jing Zhang , Ying Ding , Ariful Azad , Zhangyang Wang , Benjamin S Glicksberg

Sequential diagnosis prediction on the Electronic Health Record (EHR) has been proven crucial for predictive analytics in the medical domain. EHR data, sequential records of a patient's interactions with healthcare systems, has numerous…

Machine Learning · Computer Science 2021-09-08 Xueping Peng , Guodong Long , Tao Shen , Sen Wang , Jing Jiang

Electronic health record (EHR) data is an essential data source for machine learning for health, but researchers and clinicians face steep barriers in extracting and validating EHR data for modeling. Existing tools incur trade-offs between…

Human-Computer Interaction · Computer Science 2025-11-13 Ziyong Ma , Richard D. Boyce , Adam Perer , Venkatesh Sivaraman

Effective modeling of electronic health records (EHR) is rapidly becoming an important topic in both academia and industry. A recent study showed that using the graphical structure underlying EHR data (e.g. relationship between diagnoses…

Machine Learning · Computer Science 2020-01-22 Edward Choi , Zhen Xu , Yujia Li , Michael W. Dusenberry , Gerardo Flores , Yuan Xue , Andrew M. Dai

The inherent complexity of structured longitudinal Electronic Health Records (EHR) data poses a significant challenge when integrated with Large Language Models (LLMs), which are traditionally tailored for natural language processing.…

Computation and Language · Computer Science 2024-02-13 Yinghao Zhu , Zixiang Wang , Junyi Gao , Yuning Tong , Jingkun An , Weibin Liao , Ewen M. Harrison , Liantao Ma , Chengwei Pan

Electronic Health Records (EHRs) offer considerable potential for clinical prediction, but their complexity and heterogeneity challenge traditional machine learning. Domain-specific EHR foundation models trained on unlabeled EHR data have…

With the widespread application of electroencephalography (EEG) in neuroscience and clinical practice, efficiently retrieving and semantically interpreting large-scale, multi-source, heterogeneous EEG data has become a pressing challenge.…

Computation and Language · Computer Science 2025-10-14 Yi Wang , Haoran Luo , Lu Meng , Ziyu Jia , Xinliang Zhou , Qingsong Wen

Multimodal molecular representation learning, which jointly models molecular graphs and their textual descriptions, enhances predictive accuracy and interpretability by enabling more robust and reliable predictions of drug toxicity,…

Machine Learning · Computer Science 2025-10-21 Yingxu Wang , Kunyu Zhang , Jiaxin Huang , Nan Yin , Siwei Liu , Eran Segal

Synthesizing electronic health records (EHR) data has become a preferred strategy to address data scarcity, improve data quality, and model fairness in healthcare. However, existing approaches for EHR data generation predominantly rely on…

Machine Learning · Computer Science 2024-06-21 Yuan Zhong , Xiaochen Wang , Jiaqi Wang , Xiaokun Zhang , Yaqing Wang , Mengdi Huai , Cao Xiao , Fenglong Ma

Electronic health record (EHR) question answering is often handled by LLM-based pipelines that are costly to deploy and do not explicitly leverage the hierarchical structure of clinical data. Motivated by evidence that medical ontologies…

Artificial Intelligence · Computer Science 2026-04-24 Yuyu Liu , Sarang Rajendra Patil , Mengjia Xu , Tengfei Ma

Although the goal of achieving semantic interoperability of electronic health records (EHRs) is pursued by many researchers, it has not been accomplished yet. In this paper, we present a proposal that smoothes out the way toward the…

Artificial Intelligence · Computer Science 2024-01-23 Idoia Berges , Jesús Bermúdez , Arantza Illarramendi

This paper introduces an innovative Electronic Health Record (EHR) foundation model that integrates Polygenic Risk Scores (PRS) as a foundational data modality, moving beyond traditional EHR-only approaches to build more holistic health…

The past decade has seen an explosion in the amount of digital information stored in electronic health records (EHR). While primarily designed for archiving patient clinical information and administrative healthcare tasks, many researchers…

Machine Learning · Computer Science 2018-02-27 Benjamin Shickel , Patrick Tighe , Azra Bihorac , Parisa Rashidi

The advent of large language models (LLMs) has opened new avenues for analyzing complex, unstructured data, particularly within the medical domain. Electronic Health Records (EHRs) contain a wealth of information in various formats,…

Information Retrieval · Computer Science 2025-06-10 Wu Hao Ran , Xi Xi , Furong Li , Jingyi Lu , Jian Jiang , Hui Huang , Yuzhuan Zhang , Shi Li

Most automated electronic medical record (EMR) pipelines remain output-oriented: they transcribe, extract, and summarize after the consultation, but they do not explicitly model what is already known, what is still missing, which…

Artificial Intelligence · Computer Science 2026-03-19 Zhenhai Pan , Yan Liu , Jia You

Irregular sampling of time series in electronic health records (EHRs) is one of the main challenges for developing machine learning models. Additionally, the pattern of missing data in certain clinical variables is not at random but depends…

Machine Learning · Computer Science 2024-06-17 Hojjat Karami , David Atienza , Anisoara Ionescu

The extraction of relevant data from Electronic Health Records (EHRs) is crucial to identifying symptoms and automating epidemiological surveillance processes. By harnessing the vast amount of unstructured text in EHRs, we can detect…

Computation and Language · Computer Science 2025-02-10 Juliano Genari , Guilherme Tegoni Goedert

This study presents a fully automated methodology for early prediction studies in clinical settings, leveraging information extracted from unstructured discharge reports. The proposed pipeline uses discharge reports to support the three…

This study addresses a critical gap in the healthcare system by developing a clinically meaningful, practical, and explainable disease surveillance system for multiple chronic diseases, utilizing routine EHR data from multiple U.S.…

Machine Learning · Computer Science 2025-01-28 Shaheer Ahmad Khan , Muhammad Usamah Shahid , Ahmad Abdullah , Ibrahim Hashmat , Muddassar Farooq