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Multimodal learning aims to imitate human beings to acquire complementary information from multiple modalities for various downstream tasks. However, traditional aggregation-based multimodal fusion methods ignore the inter-modality…

Computer Vision and Pattern Recognition · Computer Science 2023-05-17 Heqing Zou , Meng Shen , Chen Chen , Yuchen Hu , Deepu Rajan , Eng Siong Chng

Open set classification (OSC) tackles the problem of determining whether the data are in-class or out-of-class during inference, when only provided with a set of in-class examples at training time. Traditional OSC methods usually train…

Machine Learning · Computer Science 2020-08-12 Yang Yang , Zhen-Qiang Sun , Hui Xiong , Jian Yang

Advances in single-cell sequencing have enabled high-resolution profiling of diverse molecular modalities, while integrating unpaired multi-omics single-cell data remains challenging. Existing approaches either rely on pair information or…

Quantitative Methods · Quantitative Biology 2026-01-21 Jianle Sun , Chaoqi Liang , Ran Wei , Peng Zheng , Lei Bai , Wanli Ouyang , Hongliang Yan , Peng Ye

Long-tailed recognition with imbalanced class distribution naturally emerges in practical machine learning applications. Existing methods such as data reweighing, resampling, and supervised contrastive learning enforce the class balance…

Computer Vision and Pattern Recognition · Computer Science 2023-09-12 Chengkai Hou , Jieyu Zhang , Haonan Wang , Tianyi Zhou

Medical image segmentation is a critical yet challenging task, primarily due to the difficulty of obtaining extensive datasets of high-quality, expert-annotated images. Contrastive learning presents a potential but still problematic…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Shuang Zeng , Lei Zhu , Xinliang Zhang , Hangzhou He , Yanye Lu

Contrastive learning has been frequently investigated to learn effective representations for text clustering tasks. While existing contrastive learning-based text clustering methods only focus on modeling instance-wise semantic similarity…

Computation and Language · Computer Science 2024-08-27 Qian Yong , Chen Chen , Xiabing Zhou

The recent breakthrough achieved by contrastive learning accelerates the pace for deploying unsupervised training on real-world data applications. However, unlabeled data in reality is commonly imbalanced and shows a long-tail distribution,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Ziyu Jiang , Tianlong Chen , Bobak Mortazavi , Zhangyang Wang

Learning robust representations to discriminate cell phenotypes based on microscopy images is important for drug discovery. Drug development efforts typically analyse thousands of cell images to screen for potential treatments. Early works…

Computer Vision and Pattern Recognition · Computer Science 2021-12-28 Alexis Perakis , Ali Gorji , Samriddhi Jain , Krishna Chaitanya , Simone Rizza , Ender Konukoglu

In recent years, the field of single-cell data analysis has seen a marked advancement in the development of clustering methods. Despite advancements, most of these algorithms still concentrate on analyzing the provided single-cell matrix…

Machine Learning · Computer Science 2023-12-18 Dayu Hu , Ke Liang , Hao Yu , Xinwang Liu

Multimodal single-cell technologies enable the simultaneous collection of diverse data types from individual cells, enhancing our understanding of cellular states. However, the integration of these datatypes and modeling the…

Machine Learning · Computer Science 2023-11-22 Bhavya Mehta , Nirmit Deliwala , Madhav Chandane

Extracting image semantics effectively and assigning corresponding labels to multiple objects or attributes for natural images is challenging due to the complex scene contents and confusing label dependencies. Recent works have focused on…

Computer Vision and Pattern Recognition · Computer Science 2023-09-26 Leilei Ma , Dengdi Sun , Lei Wang , Haifeng Zhao , Bin Luo

Spatial transcriptomics (ST) is an emerging technology that enables researchers to investigate the molecular relationships underlying tissue morphology. However, acquiring ST data remains prohibitively expensive, and traditional fixed-grid…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Junchao Zhu , Ruining Deng , Junlin Guo , Tianyuan Yao , Chongyu Qu , Juming Xiong , Siqi Lu , Zhengyi Lu , Yanfan Zhu , Marilyn Lionts , Yuechen Yang , Yalin Zheng , Yu Wang , Shilin Zhao , Haichun Yang , Yuankai Huo

Single-cell transcriptomics, epigenomics, and other 'omics applied at single-cell resolution can significantly advance hypotheses and understanding of glial biology. Omics technologies are revealing a large and growing number of new glial…

Quantitative Methods · Quantitative Biology 2024-08-14 Katherine E. Prater , Kevin Z. Lin

Single-Cell RNA sequencing (scRNA-seq) measurements have facilitated genome-scale transcriptomic profiling of individual cells, with the hope of deconvolving cellular dynamic changes in corresponding cell sub-populations to better…

Genomics · Quantitative Biology 2021-04-06 Seyednami Niyakan , Ehsan Hajiramezanali , Shahin Boluki , Siamak Zamani Dadaneh , Xiaoning Qian

Knowledge tracing and dropout prediction are crucial for online education to estimate students' knowledge states or to prevent dropout rates. While traditional systems interacting with students suffered from data sparsity and overfitting,…

Computers and Society · Computer Science 2022-10-20 Jungbae Park , Jinyoung Kim , Soonwoo Kwon , Sang Wan Lee

In digital pathology, both detection and classification of cells are important for automatic diagnostic and prognostic tasks. Classifying cells into subtypes, such as tumor cells, lymphocytes or stromal cells is particularly challenging.…

Computer Vision and Pattern Recognition · Computer Science 2022-06-07 Shahira Abousamra , David Belinsky , John Van Arnam , Felicia Allard , Eric Yee , Rajarsi Gupta , Tahsin Kurc , Dimitris Samaras , Joel Saltz , Chao Chen

Multiple Instance learning (MIL) models have been extensively used in pathology to predict biomarkers and risk-stratify patients from gigapixel-sized images. Machine learning problems in medical imaging often deal with rare diseases, making…

Computer Vision and Pattern Recognition · Computer Science 2023-09-12 Dinkar Juyal , Siddhant Shingi , Syed Ashar Javed , Harshith Padigela , Chintan Shah , Anand Sampat , Archit Khosla , John Abel , Amaro Taylor-Weiner

Class-incremental learning (CIL) in medical image-guided diagnosis requires retaining prior diagnostic knowledge while adapting to newly emerging disease categories, which is critical for scalable clinical deployment. This problem is…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Xinyao Wu , Zhe Xu , Cheng Chen , Jiawei Ma , Yefeng Zheng , Raymond Kai-yu Tong

Motivation: Multi-omics integration can improve cancer subtyping, but modality informativeness and noise vary across cancer types and patients. Existing graph-based methods optimize modality weights jointly with the classification objective…

Machine Learning · Computer Science 2026-04-28 Boyang Fan , Hengchuang Yin , Siyu Yi , Yifan Wang , Zhicheng Li , Leijiyu Zhou , Jiancheng Lv , Wei Ju

The classification of medical images is a pivotal aspect of disease diagnosis, often enhanced by deep learning techniques. However, traditional approaches typically focus on unimodal medical image data, neglecting the integration of diverse…

Image and Video Processing · Electrical Eng. & Systems 2025-11-11 Jun-En Ding , Chien-Chin Hsu , Chi-Hsiang Chu , Shuqiang Wang , Feng Liu