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Understanding the reasoning behind deep learning model predictions is crucial in cheminformatics and drug discovery, where molecular design determines their properties. However, current evaluation frameworks for Explainable AI (XAI) in this…

Machine Learning · Computer Science 2025-05-29 Magdalena Proszewska , Tomasz Danel , Dawid Rymarczyk

We share observations and challenges from an ongoing effort to implement Explainable AI (XAI) in a domain-specific workflow for cybersecurity analysts. Specifically, we briefly describe a preliminary case study on the use of XAI for source…

Human-Computer Interaction · Computer Science 2024-08-12 Ashley Suh , Harry Li , Caitlin Kenney , Kenneth Alperin , Steven R. Gomez

This work presents xEEGNet, a novel, compact, and explainable neural network for EEG data analysis. It is fully interpretable and reduces overfitting through major parameter reduction. As an applicative use case, we focused on classifying…

Machine Learning · Computer Science 2025-12-04 Andrea Zanola , Louis Fabrice Tshimanga , Federico Del Pup , Marco Baiesi , Manfredo Atzori

Breast cancer (BC) stands as one of the most common malignancies affecting women worldwide, necessitating advancements in diagnostic methodologies for better clinical outcomes. This article provides a comprehensive exploration of the…

Artificial Intelligence · Computer Science 2025-12-11 Samita Bai , Sidra Nasir , Rizwan Ahmed Khan , Alexandre Meyer , Hubert Konik

With the development of deep learning-based methods, automated classification of electrocardiograms (ECGs) has recently gained much attention. Although the effectiveness of deep neural networks has been encouraging, the lack of information…

Signal Processing · Electrical Eng. & Systems 2022-03-02 Wenrui Zhang , Xinxin Di , Guodong Wei , Shijia Geng , Zhaoji Fu , Shenda Hong

This study is located in the Human-Centered Artificial Intelligence (HCAI) and focuses on the results of a user-centered assessment of commonly used eXplainable Artificial Intelligence (XAI) algorithms, specifically investigating how humans…

This paper applies eXplainable Artificial Intelligence (XAI) methods to investigate the socioeconomic disparities in COVID patient mortality. An Extreme Gradient Boosting (XGBoost) prediction model is built based on a de-identified Austin…

Machine Learning · Computer Science 2023-02-24 Li Shi , Redoan Rahman , Esther Melamed , Jacek Gwizdka , Justin F. Rousseau , Ying Ding

Explainable AI (XAI) methods focus on explaining what a neural network has learned - in other words, identifying the features that are the most influential to the prediction. In this paper, we call them "distinguishing features". However,…

Computer Vision and Pattern Recognition · Computer Science 2021-04-19 Kaili Wang , Jose Oramas , Tinne Tuytelaars

Explainability domain generalization and rare class reliability are critical challenges in medical AI where deep models often fail under real world distribution shifts and exhibit bias against infrequent clinical conditions This paper…

Artificial Intelligence · Computer Science 2026-01-06 Midhat Urooj , Ayan Banerjee , Sandeep Gupta

Automated electrocardiogram (ECG) classification is essential for early detection of cardiovascular diseases. While recent approaches have increasingly relied on deep neural networks with complex architectures, we demonstrate that careful…

Machine Learning · Computer Science 2026-03-10 Naqcho Ali Mehdi , Amir Ali

Electrocardiogram signals are omnipresent in medicine. A vital aspect in the analysis of this data is the identification and classification of heart beat types which is often done through automated algorithms. Advancements in neural…

Machine Learning · Computer Science 2019-11-13 Tom Van Steenkiste , Dirk Deschrijver , Tom Dhaene

Data-driven artificial intelligence models require explainability in intelligent manufacturing to streamline adoption and trust in modern industry. However, recently developed explainable artificial intelligence (XAI) techniques that…

Machine Learning · Computer Science 2025-02-04 Joseph Cohen , Xun Huan , Jun Ni

A key issue in critical contexts such as medical diagnosis is the interpretability of the deep learning models adopted in decision-making systems. Research in eXplainable Artificial Intelligence (XAI) is trying to solve this issue. However,…

Computer Vision and Pattern Recognition · Computer Science 2021-11-24 Carlo Metta , Andrea Beretta , Riccardo Guidotti , Yuan Yin , Patrick Gallinari , Salvatore Rinzivillo , Fosca Giannotti

The complex nature of disease mechanisms and the variability of patient symptoms pose significant challenges in developing effective diagnostic tools. Although machine learning (ML) has made substantial advances in medical diagnosis, the…

Artificial intelligence methods are being increasingly applied across various domains, but their often opaque nature has raised concerns about accountability and trust. In response, the field of explainable AI (XAI) has emerged to address…

Neural and Evolutionary Computing · Computer Science 2024-10-18 Ryan Zhou , Jaume Bacardit , Alexander Brownlee , Stefano Cagnoni , Martin Fyvie , Giovanni Iacca , John McCall , Niki van Stein , David Walker , Ting Hu

Deep learning-based medical image analysis faces a significant barrier due to the lack of interpretability. Conventional explainable AI (XAI) techniques, such as Grad-CAM and SHAP, often highlight regions outside clinical interests. To…

Image and Video Processing · Electrical Eng. & Systems 2025-02-17 Yuhao Zhang , Mingcheng Zhu , Zhiyao Luo

The healthcare industry has been revolutionized by the convergence of Artificial Intelligence of Medical Things (AIoMT), allowing advanced data-driven solutions to improve healthcare systems. With the increasing complexity of Artificial…

Computer Vision and Pattern Recognition · Computer Science 2024-03-08 Al Amin , Kamrul Hasan , Saleh Zein-Sabatto , Deo Chimba , Imtiaz Ahmed , Tariqul Islam

The emergence of deep learning has significantly enhanced the analysis of electrocardiograms (ECGs), a non-invasive method that is essential for assessing heart health. Despite the complexity of ECG interpretation, advanced deep learning…

Machine Learning · Computer Science 2023-06-05 Zibin Zhao

In the present paper we present the potential of Explainable Artificial Intelligence methods for decision-support in medical image analysis scenarios. With three types of explainable methods applied to the same medical image data set our…

Artificial Intelligence · Computer Science 2021-05-20 Samanta Knapič , Avleen Malhi , Rohit Saluja , Kary Främling

More recently, Explainable Artificial Intelligence (XAI) research has shifted to focus on a more pragmatic or naturalistic account of understanding, that is, whether the stakeholders understand the explanation. This point is especially…

Human-Computer Interaction · Computer Science 2021-08-05 Janet Hui-wen Hsiao , Hilary Hei Ting Ngai , Luyu Qiu , Yi Yang , Caleb Chen Cao