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Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

Large language model (LLM) applications, such as ChatGPT, are a powerful tool for online information-seeking (IS) and problem-solving tasks. However, users still face challenges initializing and refining prompts, and their cognitive…

Human-Computer Interaction · Computer Science 2024-02-12 Ben Wang , Jiqun Liu , Jamshed Karimnazarov , Nicolas Thompson

In this paper, we explore the application of ChatGPT in the domain of Robust and Adaptive Robust Optimization. We demonstrate that with appropriate prompting, ChatGPT can be used to auto-formulate and solve simple Robust and Adaptive…

Optimization and Control · Mathematics 2025-01-03 Dimitris Bertsimas , Georgios Margaritis

The performance of large language models (LLMs) depends on how they are prompted, with choices spanning both the high-level prompting pattern (e.g., Zero-Shot, CoT, ReAct, ReWOO) and the specific prompt content (instructions and few-shot…

Machine Learning · Computer Science 2025-11-05 Claudio Spiess , Mandana Vaziri , Louis Mandel , Martin Hirzel

This paper explores the enhancement of small language models through strategic dataset augmentation via ChatGPT-3.5-Turbo, in the domain of Natural Language Inference (NLI). By employing knowledge distillation-based techniques and synthetic…

Computation and Language · Computer Science 2024-09-20 Tom Pieper , Mohamad Ballout , Ulf Krumnack , Gunther Heidemann , Kai-Uwe Kühnberger

In this paper, we conduct a comprehensive SWOT analysis of prompt engineering techniques within the realm of Large Language Models (LLMs). Emphasizing linguistic principles, we examine various techniques to identify their strengths,…

Computation and Language · Computer Science 2024-10-18 Aditi Singh , Abul Ehtesham , Gaurav Kumar Gupta , Nikhil Kumar Chatta , Saket Kumar , Tala Talaei Khoei

Large Language Models (LLMs) have emerged as powerful generative Artificial Intelligence solutions which can be applied to several fields and areas of work. This paper presents results and reflection of an experiment done to use the model…

Computation and Language · Computer Science 2023-12-12 Stefano De Paoli

Since the advent of large language models (LLMs), prompt engineering has been a crucial step for eliciting desired responses for various Natural Language Processing (NLP) tasks. However, prompt engineering remains an impediment for end…

Language is essentially a complex, intricate system of human expressions governed by grammatical rules. It poses a significant challenge to develop capable AI algorithms for comprehending and grasping a language. As a major approach,…

Large language models (LLMs) have achieved remarkable success across a wide spectrum of tasks; however, they still face limitations in scenarios that demand long-term planning and spatial reasoning. To facilitate this line of research, in…

Computation and Language · Computer Science 2025-02-25 Mohamed Aghzal , Erion Plaku , Ziyu Yao

The evolving pedagogy paradigms are leading toward educational transformations. One fundamental aspect of effective learning is relevant, immediate, and constructive feedback to students. Providing constructive feedback to large cohorts in…

Computers and Society · Computer Science 2025-10-14 Javed Ali Khan , Muhammad Yaqoob , Mamoona Tasadduq , Hafsa Shareef Dar , Aitezaz Ahsan

Large Language Models (LLMs) have achieved remarkable success recently, displaying exceptional capabilities in creating understandable and organized text. These LLMs have been utilized in diverse fields, such as clinical research, where…

Statistical Finance · Quantitative Finance 2025-01-17 Shuoling Liu , Gaoguo Jia , Yuhang Jiang , Liyuan Chen , Qiang Yang

Recent Large Language Models (LLMs) have significantly advanced natural language processing and automated decision-making. However, these models still encounter difficulties when performing complex reasoning tasks involving logical…

Computation and Language · Computer Science 2025-06-26 Yubo Dong , Hehe Fan

Systems engineering (SE) is evolving with the availability of generative artificial intelligence (AI) and the demand for a systems-of-systems perspective, formalized under the purview of mission engineering (ME) in the US Department of…

Software Engineering · Computer Science 2025-02-07 Max Ofsa , Taylan G. Topcu

The performance of Large Language Models (LLMs) relies heavily on the quality of prompts, which are often manually engineered and task-specific, making them costly and non-scalable. We propose a novel approach, Supervisory Prompt Training…

Computation and Language · Computer Science 2024-03-28 Jean Ghislain Billa , Min Oh , Liang Du

Scientific workflow systems are increasingly popular for expressing and executing complex data analysis pipelines over large datasets, as they offer reproducibility, dependability, and scalability of analyses by automatic parallelization on…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-07-09 Mario Sänger , Ninon De Mecquenem , Katarzyna Ewa Lewińska , Vasilis Bountris , Fabian Lehmann , Ulf Leser , Thomas Kosch

The programming capabilities of large language models (LLMs) have revolutionized automatic code generation and opened new avenues for automatic statistical analysis. However, the validity and quality of these generated codes need to be…

Pretrained large language models (LLMs) are widely used in many sub-fields of natural language processing (NLP) and generally known as excellent few-shot learners with task-specific exemplars. Notably, chain of thought (CoT) prompting, a…

Computation and Language · Computer Science 2023-01-31 Takeshi Kojima , Shixiang Shane Gu , Machel Reid , Yutaka Matsuo , Yusuke Iwasawa

Due to their architecture and vast pre-training data, large language models (LLMs) demonstrate strong text classification performance. However, LLM output - here, the category assigned to a text - depends heavily on the wording of the…

Computation and Language · Computer Science 2025-12-04 Kylie L. Anglin , Stephanie Milan , Brittney Hernandez , Claudia Ventura

This paper investigates whether large language models (LLMs) can improve cross-sectional momentum strategies by extracting predictive signals from firm-specific news. We combine daily U.S. equity returns for S&P 500 constituents with…

Portfolio Management · Quantitative Finance 2025-10-31 Nikolas Anic , Andrea Barbon , Ralf Seiz , Carlo Zarattini
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