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We present the Network-based Biased Tree Ensembles (NetBiTE) method for drug sensitivity prediction and drug sensitivity biomarker identification in cancer using a combination of prior knowledge and gene expression data. Our devised method…

Quantitative Methods · Quantitative Biology 2019-04-29 Ali Oskooei , Matteo Manica , Roland Mathis , Maria Rodriguez Martinez

Accurate identification of synergistic treatment combinations and their underlying biological mechanisms is critical across many disease domains, especially cancer. In translational oncology research, preclinical systems such as…

Applications · Statistics 2023-10-31 Tsung-Hung Yao , Zhenke Wu , Karthik Bharath , Jinju Li , Veerabhadran Baladandayuthapan

To improve patient survival and treatment outcomes, early diagnosis of brain tumors is an essential task. It is a difficult task to evaluate the magnetic resonance imaging (MRI) images manually. Thus, there is a need for digital methods for…

Computer Vision and Pattern Recognition · Computer Science 2021-01-05 Ginni Garg , Ritu Garg

Histopathological images (HI) encrypt resolution dependent heterogeneous textures & diverse color distribution variability, manifesting in micro-structural surface tissue convolutions. Also, inherently high coherency of cancerous cells…

Computer Vision and Pattern Recognition · Computer Science 2019-03-26 Sawon Pratiher , Subhankar Chattoraj

We propose novel compression algorithms for time-varying channel state information (CSI) in wireless communications. The proposed scheme combines (lossy) vector quantisation and (lossless) compression. First, the new vector quantisation…

Information Theory · Computer Science 2022-10-04 Henrique K. Miyamoto , Sheng Yang

We study learning-augmented binary search trees (BSTs) via Treaps with carefully designed priorities. The result is a simple search tree in which the depth of each item $x$ is determined by its predicted weight $w_x$. Specifically, each…

Data Structures and Algorithms · Computer Science 2025-05-16 Jingbang Chen , Xinyuan Cao , Alicia Stepin , Li Chen

Persistence diagrams have been widely used to quantify the underlying features of filtered topological spaces in data visualization. In many applications, computing distances between diagrams is essential; however, computing these distances…

Computational Geometry · Computer Science 2021-08-12 Yu Qin , Brittany Terese Fasy , Carola Wenk , Brian Summa

Brain tumor is a common and fatal form of cancer which affects both adults and children. The classification of brain tumors into different types is hence a crucial task, as it greatly influences the treatment that physicians will prescribe.…

Computer Vision and Pattern Recognition · Computer Science 2021-08-10 Tian Yu Liu , Jiashi Feng

Discovery of diagnostic and prognostic molecular markers is important and actively pursued the research field in cancer research. For complex diseases, this process is often performed using Machine Learning. The current study compares two…

Genomics · Quantitative Biology 2020-04-30 Aneta Polewko-Klim , Witold R. Rudnicki

We study rotation-robust learning for image inputs using Convolutional Model Trees (CMTs) [1], whose split and leaf coefficients can be structured on the image grid and transformed geometrically at deployment time. In a controlled MNIST…

Computer Vision and Pattern Recognition · Computer Science 2026-01-09 Hongyi Li , William Ward Armstrong , Jun Xu

This paper explores interpretability techniques for two of the most successful learning algorithms in medical decision-making literature: deep neural networks and random forests. We applied these algorithms in a real-world medical dataset…

Machine Learning · Computer Science 2020-02-24 Catarina Moreira , Renuka Sindhgatta , Chun Ouyang , Peter Bruza , Andreas Wichert

Significant advances in biotechnology have allowed for simultaneous measurement of molecular data points across multiple genomic and transcriptomic levels from a single tumor/cancer sample. This has motivated systematic approaches to…

In deep neural networks, better results can often be obtained by increasing the complexity of previously developed basic models. However, it is unclear whether there is a way to boost performance by decreasing the complexity of such models.…

Machine Learning · Computer Science 2022-06-07 Junran Wu , Shangzhe Li , Jianhao Li , Yicheng Pan , Ke Xu

Random Forest (RF) is a widely used ensemble learning technique known for its robust classification performance across diverse domains. However, it often relies on hundreds of trees and all input features, leading to high inference cost and…

Machine Learning · Computer Science 2025-07-08 Sijan Bhattarai , Saurav Bhandari , Girija Bhusal , Saroj Shakya , Tapendra Pandey

Tree-based algorithms such as random forests and gradient boosted trees continue to be among the most popular and powerful machine learning models used across multiple disciplines. The conventional wisdom of estimating the impact of a…

Machine Learning · Statistics 2022-01-03 Markus Loecher , Qi Wu

Algorithms for binary classification based on adaptive tree partitioning are formulated and analyzed for both their risk performance and their friendliness to numerical implementation. The algorithms can be viewed as generating a set…

Statistics Theory · Mathematics 2014-11-05 Peter Binev , Albert Cohen , Wolfgang Dahmen , Ronald DeVore

We present an algorithm for classification tasks on big data. Experiments conducted as part of this study indicate that the algorithm can be as accurate as ensemble methods such as random forests or gradient boosted trees. Unlike ensemble…

Machine Learning · Statistics 2017-10-27 Rajiv Sambasivan , Sourish Das

Recent advances in computer vision and robotics enabled automated large-scale biological image analysis. Various machine learning approaches have been successfully applied to phenotypic profiling. However, it remains unclear how they…

Image and Video Processing · Electrical Eng. & Systems 2022-03-09 Andrei Dmitrenko , Mauro M. Masiero , Nicola Zamboni

In this paper, we propose a novel learning based method for automated segmentation of brain tumor in multimodal MRI images, which incorporates two sets of machine -learned and hand crafted features. Fully convolutional networks (FCN) forms…

Computer Vision and Pattern Recognition · Computer Science 2020-08-10 Mohammadreza Soltaninejad , Lei Zhang , Tryphon Lambrou , Guang Yang , Nigel Allinson , Xujiong Ye

The prediction plays the important role in detecting efficient protection and therapy of cancer. The prediction of mutations in gene needs a diagnostic and classification, which is based on the whole database (big dataset), to reach…

Machine Learning · Computer Science 2016-08-10 Ayad Ghany Ismaeel , Dina Yousif Mikhail